scholarly article | Q13442814 |
P50 | author | Paolo Ruzza | Q55117899 |
Andrea Calderan | Q30169309 | ||
P2093 | author name string | Paolo Ruzza | |
Andrea Calderan | |||
P2860 | cites work | Mutation of an evolutionarily conserved tyrosine residue in the active site of a human class Alpha glutathione transferase | Q68070730 |
Tissue distribution of drug-metabolizing enzymes in humans | Q70407156 | ||
Comparison of the distribution of microsomal and cytosolic glutathione S-transferase activities in different organs of the rat | Q71678809 | ||
Targeting of 6-mercaptopurine to the kidneys. Metabolism and kidney-selectivity of S-(6-purinyl)-L-cysteine analogs in rats | Q72658514 | ||
Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats | Q78149307 | ||
Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamides | Q78167608 | ||
Divergent activities of human glutathione transferases in the bioactivation of azathioprine | Q83825841 | ||
Tyrosine-7 in human class Pi glutathione S-transferase is important for lowering the pKa of the thiol group of glutathione in the enzyme-glutathione complex | Q43738588 | ||
Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice | Q43926096 | ||
Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells | Q44248610 | ||
Spectroscopic and kinetic evidence for the thiolate anion of glutathione at the active site of glutathione S-transferase | Q44500793 | ||
Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase. | Q46159333 | ||
Sulphonamide-based bombesin prodrug analogues for glutathione transferase, useful in targeted cancer chemotherapy. | Q46238032 | ||
Glutathione transferase: new model for glutathione activation | Q46367408 | ||
Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer | Q46598239 | ||
Nomenclature for mammalian soluble glutathione transferases | Q46884286 | ||
Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs. | Q53751966 | ||
Expression of glutathione-S-transferases alpha and pi in gastric cancer: a correlation with cisplatin resistance. | Q54220328 | ||
Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. | Q54419426 | ||
Regulation of JNK signaling by GSTp | Q24533822 | ||
Plant glutathione transferases | Q24791124 | ||
Identification, characterization, and crystal structure of the Omega class glutathione transferases | Q27622324 | ||
A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implications | Q27760244 | ||
The three-dimensional structure of a class-Pi glutathione S-transferase complexed with glutathione: the active-site hydration provides insights into the reaction mechanism | Q27764867 | ||
Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae | Q28360849 | ||
Glutathione transferases | Q29616501 | ||
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance | Q29616511 | ||
Cellular mechanisms of multidrug resistance of tumor cells. | Q33854298 | ||
Reviewing the mechanism of action of thiopurine drugs: towards a new paradigm in clinical practice. | Q33982674 | ||
Glutathione conjugation as a bioactivation reaction | Q34129195 | ||
Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana | Q34134539 | ||
JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells | Q34214362 | ||
Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics. | Q34296339 | ||
Structure, catalytic mechanism, and evolution of the glutathione transferases | Q34419894 | ||
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix | Q34485882 | ||
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells | Q35900943 | ||
Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1. | Q36803888 | ||
Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs. | Q37074670 | ||
Glutathione transferases as targets for cancer therapy. | Q37524192 | ||
Anticancer prodrugs: an overview of major strategies and recent developments. | Q37889319 | ||
Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug | Q40563895 | ||
Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen | Q40587148 | ||
Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer. | Q40613245 | ||
JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity | Q40654617 | ||
Glutathione-associated enzymes in anticancer drug resistance. | Q40680199 | ||
Cellular response to a glutathione S-transferase P1-1 activated prodrug. | Q40872836 | ||
Activated sulfonamides are cleaved by glutathione-S-transferases | Q40933524 | ||
Glutathione and related enzymes in multidrug resistance | Q41078132 | ||
Toxicity of chemotherapy | Q41114986 | ||
Design, synthesis, and evaluation of latent alkylating agents activated by glutathione S-transferase | Q41206146 | ||
Cellular resistance to anthracyclines. | Q41213895 | ||
Glutathione-S-transferase activates novel alkylating agents | Q41468200 | ||
Mutagenesis of the active site of the human Theta-class glutathione transferase GSTT2-2: catalysis with different substrates involves different residues | Q41986526 | ||
Expression of class Pi glutathione transferase in human malignant melanoma cells | Q42155176 | ||
Membrane gamma-glutamyl transpeptidase activity of melanoma cells: effects on cellular H(2)O(2) production, cell surface protein thiol oxidation and NF-kappa B activation status. | Q42490514 | ||
P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 2 | |
P921 | main subject | glutathione | Q116907 |
P304 | page(s) | 220-231 | |
P577 | publication date | 2013-04-02 | |
P1433 | published in | Pharmaceutics | Q27723332 |
P1476 | title | Glutathione Transferase (GST)-Activated Prodrugs | |
P478 | volume | 5 |
Q38786434 | Design and synthesis of 2-substituted-5-(4-trifluoromethylphenyl-sulphonamido)benzoxazole derivatives as human GST P1-1 inhibitors |
Q46260613 | Effect of interaction of glutathione S-transferases (T1 and M1) on the hematologic and cytogenetic responses in chronic myeloid leukemia patients treated with imatinib |
Q37526768 | Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction |
Q60932204 | Glutathione Transferases: Potential Targets to Overcome Chemoresistance in Solid Tumors |
Q48181201 | Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases. |
Q38724701 | Human cytosolic glutathione-S-transferases: quantitative analysis of expression, comparative analysis of structures and inhibition strategies of isozymes involved in drug resistance |
Q47298697 | Synthesis and molecular modeling of new benzimidazoles as glutathione S-transferase inhibitors and anticancer agents. |
Q26752606 | The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants |
Q52560078 | The expanding role of prodrugs in contemporary drug design and development. |
Search more.