Glutathione Transferase (GST)-Activated Prodrugs.

scientific article published on 02 April 2013

Glutathione Transferase (GST)-Activated Prodrugs. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/PHARMACEUTICS5020220
P932PMC publication ID3834953
P698PubMed publication ID24300447
P5875ResearchGate publication ID259153720

P50authorPaolo RuzzaQ55117899
Andrea CalderanQ30169309
P2093author name stringPaolo Ruzza
Andrea Calderan
P2860cites workMutation of an evolutionarily conserved tyrosine residue in the active site of a human class Alpha glutathione transferaseQ68070730
Tissue distribution of drug-metabolizing enzymes in humansQ70407156
Comparison of the distribution of microsomal and cytosolic glutathione S-transferase activities in different organs of the ratQ71678809
Targeting of 6-mercaptopurine to the kidneys. Metabolism and kidney-selectivity of S-(6-purinyl)-L-cysteine analogs in ratsQ72658514
Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in ratsQ78149307
Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamidesQ78167608
Divergent activities of human glutathione transferases in the bioactivation of azathioprineQ83825841
Tyrosine-7 in human class Pi glutathione S-transferase is important for lowering the pKa of the thiol group of glutathione in the enzyme-glutathione complexQ43738588
Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in miceQ43926096
Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cellsQ44248610
Spectroscopic and kinetic evidence for the thiolate anion of glutathione at the active site of glutathione S-transferaseQ44500793
Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase.Q46159333
Sulphonamide-based bombesin prodrug analogues for glutathione transferase, useful in targeted cancer chemotherapy.Q46238032
Glutathione transferase: new model for glutathione activationQ46367408
Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancerQ46598239
Nomenclature for mammalian soluble glutathione transferasesQ46884286
Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.Q53751966
Expression of glutathione-S-transferases alpha and pi in gastric cancer: a correlation with cisplatin resistance.Q54220328
Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.Q54419426
Regulation of JNK signaling by GSTpQ24533822
Plant glutathione transferasesQ24791124
Identification, characterization, and crystal structure of the Omega class glutathione transferasesQ27622324
A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implicationsQ27760244
The three-dimensional structure of a class-Pi glutathione S-transferase complexed with glutathione: the active-site hydration provides insights into the reaction mechanismQ27764867
Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiaeQ28360849
Glutathione transferasesQ29616501
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistanceQ29616511
Cellular mechanisms of multidrug resistance of tumor cells.Q33854298
Reviewing the mechanism of action of thiopurine drugs: towards a new paradigm in clinical practice.Q33982674
Glutathione conjugation as a bioactivation reactionQ34129195
Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thalianaQ34134539
JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cellsQ34214362
Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics.Q34296339
Structure, catalytic mechanism, and evolution of the glutathione transferasesQ34419894
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helixQ34485882
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cellsQ35900943
Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1.Q36803888
Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs.Q37074670
Glutathione transferases as targets for cancer therapy.Q37524192
Anticancer prodrugs: an overview of major strategies and recent developments.Q37889319
Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrugQ40563895
Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screenQ40587148
Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer.Q40613245
JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activityQ40654617
Glutathione-associated enzymes in anticancer drug resistance.Q40680199
Cellular response to a glutathione S-transferase P1-1 activated prodrug.Q40872836
Activated sulfonamides are cleaved by glutathione-S-transferasesQ40933524
Glutathione and related enzymes in multidrug resistanceQ41078132
Toxicity of chemotherapyQ41114986
Design, synthesis, and evaluation of latent alkylating agents activated by glutathione S-transferaseQ41206146
Cellular resistance to anthracyclines.Q41213895
Glutathione-S-transferase activates novel alkylating agentsQ41468200
Mutagenesis of the active site of the human Theta-class glutathione transferase GSTT2-2: catalysis with different substrates involves different residuesQ41986526
Expression of class Pi glutathione transferase in human malignant melanoma cellsQ42155176
Membrane gamma-glutamyl transpeptidase activity of melanoma cells: effects on cellular H(2)O(2) production, cell surface protein thiol oxidation and NF-kappa B activation status.Q42490514
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P921main subjectglutathioneQ116907
P304page(s)220-231
P577publication date2013-04-02
P1433published inPharmaceuticsQ27723332
P1476titleGlutathione Transferase (GST)-Activated Prodrugs
P478volume5

Reverse relations

cites work (P2860)
Q38786434Design and synthesis of 2-substituted-5-(4-trifluoromethylphenyl-sulphonamido)benzoxazole derivatives as human GST P1-1 inhibitors
Q46260613Effect of interaction of glutathione S-transferases (T1 and M1) on the hematologic and cytogenetic responses in chronic myeloid leukemia patients treated with imatinib
Q37526768Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction
Q60932204Glutathione Transferases: Potential Targets to Overcome Chemoresistance in Solid Tumors
Q48181201Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases.
Q38724701Human cytosolic glutathione-S-transferases: quantitative analysis of expression, comparative analysis of structures and inhibition strategies of isozymes involved in drug resistance
Q47298697Synthesis and molecular modeling of new benzimidazoles as glutathione S-transferase inhibitors and anticancer agents.
Q26752606The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants
Q52560078The expanding role of prodrugs in contemporary drug design and development.

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