Regulation of JNK signaling by GSTp

scientific article

Regulation of JNK signaling by GSTp is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/EMBOJ/18.5.1321
P3181OpenCitations bibliographic resource ID1413682
P932PMC publication ID1171222
P698PubMed publication ID10064598
P5875ResearchGate publication ID13225259

P2093author name stringC J Henderson
C R Wolf
K D Tew
Z Ronai
R J Davis
V Adler
Z Yin
M R Pincus
M Benezra
M Sardana
S Y Fuchs
L Rosario
P2860cites workJNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extensionQ22007973
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tensionQ24307473
A model for p53-induced apoptosisQ24313374
Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzymeQ24555669
The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphataseQ24561826
Expression cloning of a human dual-specificity phosphataseQ24562377
Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinaseQ24655723
c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factorsQ28257088
Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to developmentQ28268881
A mammalian scaffold complex that selectively mediates MAP kinase activationQ28281953
Transcription factor ATF2 regulation by the JNK signal transduction pathwayQ28305631
Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinaseQ28567939
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosisQ29547567
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathwayQ29614258
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domainQ29614381
The stress-activated protein kinase subfamily of c-Jun kinasesQ29620001
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKKQ29620274
Complexes of p21RAS with JUN N-terminal kinase and JUN proteinsQ33786380
Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cellsQ34480909
Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation.Q35196825
JNK targets p53 ubiquitination and degradation in nonstressed cellsQ35208651
Conformation-dependent phosphorylation of p53.Q36019930
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferasesQ36068630
Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cellsQ36105342
Activation of protein kinase C by tyrosine phosphorylation in response to H2O2.Q36590164
Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domainQ37055760
MEKK1/JNK signaling stabilizes and activates p53.Q37474256
UV irradiation and heat shock mediate JNK activation via alternate pathways.Q38289506
Glutathione transferases as markers of preneoplasia and neoplasiaQ38655792
The GlutathioneS-Transferases: A Group of Multifunctional Detoxification ProteinsQ39719839
The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agentsQ40023085
Glutathione-associated enzymes in anticancer drug resistance.Q40680199
Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53.Q41004423
A non-enzymatic p21 protein inhibitor of stress-activated protein kinasesQ41190478
Impaired jun-NH2-terminal kinase activation by ultraviolet irradiation in fibroblasts of patients with Cockayne syndrome complementation group B.Q41194461
MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?Q41345475
v-Src and EJ Ras alleviate repression of c-Jun by a cell-specific inhibitorQ41675040
Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell linesQ41740289
Oxygen radicals and signalingQ41750986
Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinasesQ42804655
Activation of c-Jun-NH2-kinase by UV irradiation is dependent on p21rasQ42808831
Involvement of glutathione in induction of c-jun proto-oncogene by methylmethanesulfonate in NIH 3T3 cellsQ42814860
Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injuryQ42816281
jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells.Q42822966
DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.Q46784718
An osmosensing signal transduction pathway in mammalian cellsQ48080102
Immunohistochemical localization of glutathione S-transferases α μ and π in normal tissue and carcinomas from human colonQ53495172
Isozyme specificity of novel glutathione-S-transferase inhibitors.Q54253506
Integration of MAP kinase signal transduction pathways at the serum response elementQ58415341
Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acidQ68028183
Identification of cysteine residues involved in disulfide formation in the inactivation of glutathione transferase P-form by hydrogen peroxideQ70539826
Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinasesQ71143796
JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytesQ71574085
Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinaseQ72724630
Stress-activated kinases regulate protein stabilityQ77436414
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1321-34
P577publication date1999-03-01
P1433published inThe EMBO JournalQ1278554
P1476titleRegulation of JNK signaling by GSTp
P478volume18

Reverse relations

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Q38045418Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences
Q42496040Inhibition of aberrant and constitutive phosphorylation of the high-molecular-mass neurofilament subunit by CEP-1347 (KT7515), an inhibitor of the stress-activated protein kinase signaling pathway
Q90749046Inhibition of glutathione S-transferase-pi triggers c-jun N-terminal kinase-dependent neuronal death in Zn-induced Parkinsonism
Q39812389Insulin resistance and hepatocarcinogenesis
Q41829379Interaction of Omega, Sigma, and Theta glutathione transferases with p38b mitogen-activated protein kinase from the fruit fly, Drosophila melanogaster
Q44279157Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems
Q36790471Interplay between Hepatitis C Virus and Redox Cell Signaling
Q38928796Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs
Q46931476Involvement of glutathione/glutathione S-transferase antioxidant system in butyrate-inhibited vascular smooth muscle cell proliferation
Q40634523Involvement of the JNK-like protein of the Aedes albopictus mosquito cell line, C6/36, in phagocytosis, endocytosis and infection of West Nile virus
Q43093356Isoenzyme profile of glutathione transferases in transitional cell carcinoma of upper urinary tract.
Q42647706Isolation of hyperactive mutants of the MAPK p38/Hog1 that are independent of MAPK kinase activation
Q33887876JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system
Q28564577JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length
Q37855792Knockout and transgenic mice in glutathione transferase research
Q30975969Lack of glutathione conjugation to adriamycin in human breast cancer MCF-7/DOX cells. Inhibition of glutathione S-transferase p1-1 by glutathione conjugates from anthracyclines
Q46704667Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal.
Q44172115Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation.
Q28237402Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia
Q30165030Longevity determination genes in Drosophila melanogaster
Q34517167Low levels of GSTA1 expression are required for Caco-2 cell proliferation
Q35902785Lymphoma cells with increased anti-oxidant defenses acquire chemoresistance
Q37420626Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.
Q39690234Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling
Q26998806Mechanisms of drug-induced liver injury
Q38077215Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling
Q35102961Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases
Q35326954Micro-plasticity of genomes as illustrated by the evolution of glutathione transferases in 12 Drosophila species
Q37460232Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration
Q41880271Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster
Q24530734Modelling and bioinformatics studies of the human Kappa-class glutathione transferase predict a novel third glutathione transferase family with similarity to prokaryotic 2-hydroxychromene-2-carboxylate isomerases
Q42226736Modulation of ASK1 expression during overexpression of Trx and HSP70 in stressed fish liver mitochondria
Q38931697Modulation of apoptosis by sulforaphane is associated with PGC-1α stimulation and decreased oxidative stress in cardiac myoblasts
Q74481047Molecular analysis of mitogen-activated protein kinase signaling pathways induced by reactive oxygen intermediates
Q57807148Molecular evaluation of glutathione S transferase family genes in patients with sporadic colorectal cancer
Q33951094Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease
Q42807112N-acetylcysteine inhibits kinase phosphorylation during 3T3-L1 adipocyte differentiation.
Q28252988NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics
Q37265507NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology
Q39804728NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death
Q56909288NOV-002, a mimetic of glutathione disulfide
Q48174531Natural Dietary Pigments: Potential Mediators against Hepatic Damage Induced by Over-The-Counter Non-Steroidal Anti-Inflammatory and Analgesic Drugs.
Q40584612Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione
Q37885200Nitrosyl iron complexes--synthesis, structure and biology
Q38320483Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo
Q46884286Nomenclature for mammalian soluble glutathione transferases
Q43635405Non-Jewish Israeli IBD patients have significantly higher glutathione S-transferase GSTT1-null frequency
Q44157636Non-active site residues Cys69 and Asp150 affected the enzymatic properties of glutathione S-transferase AdGSTD3-3
Q37258656Noncatalytic interactions between glutathione S-transferases and nitroalkene fatty acids modulate nitroalkene-mediated activation of peroxisomal proliferator-activated receptor gamma
Q28397449Novel peptides from the RAS-p21 and p53 proteins for the treatment of cancer
Q37029859Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress
Q37997003Novel roles of peroxiredoxins in inflammation, cancer and innate immunity
Q40108785Novel use of the fluorescent dye 5-(and-6)-chloromethyl SNARF-1 acetate for the measurement of intracellular glutathione in leukemic cells and primary lymphocytes
Q37721838Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis
Q36209099On marathons and Sprints: an integrated quantitative proteomics and transcriptomics analysis of differences between slow and fast muscle fibers
Q60960944On the Inhibition Mechanism of Glutathione Transferase P1 by Piperlongumine. Insight From Theory
Q35607713Oral ezatiostat HCl (Telintra®, TLK199) and idiopathic chronic neutropenia (ICN): a case report of complete response of a patient with G-CSF resistant ICN following treatment with ezatiostat, a glutathione S-transferase P1-1 (GSTP1-1) inhibitor
Q39803653Oxaliplatin-induced neuropathy in colorectal cancer
Q28131725Oxidants, oxidative stress and the biology of ageing
Q34397394Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding
Q51295065Oxidative DNA damage and activation of c-Jun N-terminal kinase pathway in fibroblasts from patients with hereditary spastic paraplegia.
Q64084056Oxidative Imbalance and Kidney Damage in Cafeteria Diet-Induced Rat Model of Metabolic Syndrome: Effect of Bergamot Polyphenolic Fraction
Q39321654Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis
Q38069883Oxidative stress and antioxidant defense
Q26853196Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?
Q37906539Oxidative stress in synapse development and function
Q38207007Oxidative stress in the etiology of age-associated decline in glucose metabolism
Q35409729Oxidative stress induces overgrowth of the Drosophila neuromuscular junction
Q30433525Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain
Q35611511Oxidative stress, redox regulation and diseases of cellular differentiation
Q37274139PEP-1-GSTpi protein enhanced hippocampal neuronal cell survival after oxidative damage
Q30805871Peptide phage display for probing GST-protein interactions
Q28070359Peroxiredoxin 1 - an antioxidant enzyme in cancer
Q51711572Pharmacogenetic association between GSTP1 genetic polymorphism and febrile neutropenia in Japanese patients with early breast cancer.
Q35553827Pharmacogenomics of cisplatin-induced ototoxicity
Q41956100Pharmacology of a mimetic of glutathione disulfide, NOV-002.
Q37222119Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome.
Q36407256Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells
Q40777240Phosphorylation of proteins and apoptosis induced by c-Jun N-terminal kinase1 activation in rat cardiomyocytes by H(2)O(2) stimulation
Q34619307Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer
Q37364876Pleiotropic functions of glutathione S-transferase P
Q44934830Polymorphisms of GSTP1 and related genes and prostate cancer risk
Q42951273Porcine glutathione transferase Alpha 2-2 is a human GST A3-3 analogue that catalyses steroid double-bond isomerization
Q48797271Possible prenatal impact of sertraline on human placental glutathione S-transferase-π.
Q34074329Postischemic deactivation of cardiac aldose reductase: role of glutathione S-transferase P and glutaredoxin in regeneration of reduced thiols from sulfenic acids
Q33876235Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort
Q36613823Prognostic impact of multidrug resistance gene expression on the management of breast cancer in the context of adjuvant therapy based on a series of 171 patients
Q46518382Prognostic role of glutathione S-transferase polymorphisms in acute myeloid leukemia
Q51034997Promoter methylation and gene polymorphism are two independent events in regulation of GSTP1 gene expression.
Q39985733Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response
Q46922228Protein expression in human cumulus cells as an indicator of blastocyst formation and pregnancy success.
Q35843744Protein kinase function and glutathionylation
Q34341284Proteomic analysis of glutathione S-transferase isoforms in mouse liver mitochondria
Q40639543Proteomic analysis of hematopoietic stem cell-like fractions in leukemic disorders
Q34138958Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors
Q24811682Proteomic approaches to characterize protein modifications: new tools to study the effects of environmental exposures
Q33213431Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells
Q34082869Proteomic signatures of human oral epithelial cells in HIV-infected subjects
Q39671003Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase π
Q28345250Purification and characterization of a glutathione S-transferase Omega in pig: evidence for two distinct organ-specific transcripts
Q35956182Quinone reductases multitasking in the metabolic world
Q39266098Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide
Q38843258Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway
Q37774919Reactive oxygen species in TNFalpha-induced signaling and cell death.
Q24349073Reactive oxygen species in the activation and regulation of intracellular signaling events
Q60950835Reactive oxygen species regulate activity-dependent neuronal plasticity in
Q41825747Reciprocal regulation of glutathione S-transferase spliceforms and the Drosophila c-Jun N-terminal kinase pathway components
Q24310029Recombinant protein glutathione S-transferases P1 attenuates inflammation in mice
Q37802379Redox Balance in the Pathogenesis of Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities
Q33830140Redox control of liver function in health and disease
Q35707262Redox control of signal transduction, gene expression and cellular senescence
Q37772328Redox metabolism and malignancy
Q34777711Redox platforms in cancer drug discovery and development
Q35120722Redox regulation and signaling lipids in mitochondrial apoptosis
Q37181226Redox regulation of cell survival
Q33644327Redox regulation of tumor necrosis factor signaling
Q28397611Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death
Q36756386Redox-based regulation of signal transduction: principles, pitfalls, and promises
Q46470681Reduction of GSTP1 expression by DNA methylation correlates with clinicopathological features in pituitary adenomas
Q38085856Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria
Q28509457Regulation of lipopolysaccharide-induced inflammatory response by glutathione S-transferase P1 in RAW264.7 cells
Q33989877Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches.
Q41901021Regulation of signal transduction by glutathione transferases
Q24293209Regulation of the cardiac muscle ryanodine receptor by glutathione transferases
Q36155865Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxification
Q46119122Relationship between GSTP1 Ile(105)Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity.
Q33756205Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity
Q26822957Repair of oxidative DNA damage and cancer: recent progress in DNA base excision repair
Q40646994Resistance to phorbol 12-myristate 13-acetate-induced cell growth arrest in an HL60 cell line chronically exposed to a glutathione S-transferase π inhibitor
Q23918077Respiratory burst: role in signal transduction in alveolar macrophages
Q30765231Reverse two-hybrid screening identifies residues of JNK required for interaction with the kinase interaction motif of JNK-interacting protein-1.
Q40734751Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation
Q33965815Role for mitochondrial oxidants as regulators of cellular metabolism
Q92597833Role of AccMGST1 in oxidative stress resistance in Apis cerana cerana
Q40719119Role of GST P1-1 in mediating the effect of etoposide on human neuroblastoma cell line Sh-Sy5y
Q38992254Role of Glutathione-S-transferases in neurological problems
Q39929809Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin
Q38114436Role of glutathione in cancer progression and chemoresistance
Q35916588Role of mitochondrial homeostasis and dynamics in Alzheimer's disease
Q54027395Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells.
Q23924205Role of reactive oxygen species and MAPKs in vanadate-induced G2/M phase arrest
Q33771754Role of redox potential and reactive oxygen species in stress signaling
Q28140867Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis
Q40870782Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium
Q42022492Roles of Mitochondrial DNA Changes on Cancer Initiation and Progression
Q53120803S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection.
Q30398587S-glutathionylation: from molecular mechanisms to health outcomes
Q37058729S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response.
Q36873620S-nitrosation of glutathione transferase p1-1 is controlled by the conformation of a dynamic active site helix.
Q59613491Selective Inhibitors of Glutathione Transferase P1 with Trioxane Structure as Anticancer Agents
Q45017292Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria
Q38327079Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors.
Q40185539Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cells
Q30932122Selective recognition of peptide sequences by glutathione transferases: a possible mechanism for modulation of cellular stress-induced signaling pathways.
Q24793538Sensitivity and fidelity of DNA microarray improved with integration of Amplified Differential Gene Expression (ADGE)
Q35859386Serum glutathione S-transferase P1 1 in prediction of cardiac function
Q37855791Sigma-class glutathione transferases.
Q29615230Signal transduction by reactive oxygen species
Q28142592Signal transduction by the JNK group of MAP kinases
Q26829903Signal transduction inhibitors in treatment of myelodysplastic syndromes
Q90703648Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction
Q28909763Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo
Q40121643Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.
Q39166555Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine
Q24533519Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily
Q36231404Sulfiredoxin: a potential therapeutic agent?
Q40664009Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells
Q28478529Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells
Q47329610Synthesis and activity mechanism of some novel 2-substituted benzothiazoles as hGSTP1-1 enzyme inhibitors.
Q87544959Synthesis and biological evaluation of 2-substituted-5-(4-nitrophenylsulfonamido)benzoxazoles as human GST P1-1 inhibitors, and description of the binding site features
Q45158753TEGDMA modulates glutathione transferase P1 activity in gingival fibroblasts
Q34374468THE GSTP1 c.313A>G POLYMORPHISM MODULATES THE CARDIORESPIRATORY RESPONSE TO AEROBIC TRAINING.
Q37299479TNFR1 signaling kinetics: spatiotemporal control of three phases of IKK activation by posttranslational modification
Q37095205TNFalpha and reactive oxygen species in necrotic cell death
Q34581769Targeted tumor gene therapy based on loss of IGF2 imprinting
Q39446187Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines.
Q34009844Targeting Glutathione S-transferase M4 in Ewing sarcoma
Q46499332Targeting Nrf2 with wogonin overcomes cisplatin resistance in head and neck cancer
Q38817271Targeting the expression of glutathione- and sulfate-dependent detoxification enzymes in HepG2 cells by oxygen in minimal and amino acid enriched medium.
Q54498834Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease.
Q34039684Testicular cancer survivorship: research strategies and recommendations
Q41961494Tetramerization and cooperativity in Plasmodium falciparum glutathione S-transferase are mediated by atypic loop 113-119.
Q40224958The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages
Q43011025The AoPR10 promoter and certain endogenous PR10 genes respond to oxidative signals in Arabidopsis
Q28551389The Effect of Chronic Methamphetamine Exposure on the Hippocampal and Olfactory Bulb Neuroproteomes of Rats
Q90067850The Formation of a Camalexin Biosynthetic Metabolon
Q36128683The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes.
Q44019750The Gerhard Zbinden memorial lecture: application of biochemical and genetic approaches to understanding pathways of chemical toxicity
Q44619133The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines
Q24305978The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine receptor calcium channels
Q26775729The antioxidant master glutathione and periodontal health
Q34269360The changing faces of glutathione, a cellular protagonist
Q36990410The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal.
Q27629457The crystal structure of the nitrogen regulation fragment of the yeast prion protein Ure2p
Q40493236The effect of C-terminal fragment of JNK2 on the stability of p53 and cell proliferation
Q22254262The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death
Q33695114The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex
Q37856253The glutathione transferase kappa family
Q24290416The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator
Q41571797The impact of GSTM1/GSTT1 polymorphism for the risk of oral cancer
Q28180886The importance of glutathione in human disease
Q24307307The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor
Q37292416The interactions of flavonoids within neuronal signalling pathways
Q37904152The interplay of glutathione-related processes in antioxidant defense
Q28382920The redox state of cytochrome c modulates resistance to methotrexate in human MCF7 breast cancer cells
Q28541169The role of N-acetyltransferase 8 in mesenchymal stem cell-based therapy for liver ischemia/reperfusion injury in rats
Q24603861The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer
Q34272162The role of glutathione-S-transferase in anti-cancer drug resistance
Q43477300The role of the inhibition of glutathione-S-transferase in the protective mechanisms of ischemic postconditioning
Q41104826The silkworm GSTe4 is sensitive to phoxim and protects HEK293 cells against UV-induced cell apoptosis
Q24309820The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide
Q42156273The structural roles of a conserved small hydrophobic core in the active site and an ionic bridge in domain I of Delta class glutathione S-transferase
Q40399626The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity
Q36835830The use of glutathione transferase-knockout mice as pharmacological and toxicological models
Q37564522Therapeutic peptides for cancer therapy. Part I - peptide inhibitors of signal transduction cascades.
Q39430380Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles' heel
Q36347320Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation
Q33701863Through translational prospective study, the GSTP1 Ile105Val polymorphism emerges as prognostic marker in de novo large B-cell lymphoma patients
Q34314855Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells
Q42469077Transient anoxia and oxyradicals induce a region-specific activation of MAPKs in the embryonic heart
Q28085631Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies
Q37285088Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor
Q43524396Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice
Q38090712Utilization of glutathione S-transferase Mu 1- and Theta 1-null mice as animal models for absorption, distribution, metabolism, excretion and toxicity studies
Q89977976Weaning Mice and Adult Mice Exhibit Differential Carbon Tetrachloride-Induced Acute Hepatotoxicity
Q41769734c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.
Q35836408tau kinases in the rat heat shock model: possible implications for Alzheimer disease
Q27666187Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for 'ping pong' kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton ab

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