| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M404912200 |
| P698 | PubMed publication ID | 15161912 |
| P50 | author | Michael P. Waalkes | Q113460555 |
| P2093 | author name string | Elaine M Leslie | |
| Anass Haimeur | |||
| P2860 | cites work | Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line | Q24338329 |
| Regulation of JNK signaling by GSTp | Q24533822 | ||
| Pathways of As(III) detoxification in Saccharomyces cerevisiae. | Q27931719 | ||
| Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells | Q28369884 | ||
| The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic | Q30607266 | ||
| Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. | Q31645457 | ||
| Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein | Q33999305 | ||
| The MRP1-mediated effluxes of arsenic and antimony do not require arsenic-glutathione and antimony-glutathione complex formation. | Q34129121 | ||
| The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation | Q34298925 | ||
| Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters. | Q34369690 | ||
| Reactive intermediates and the dynamics of glutathione transferases | Q34849031 | ||
| Biochemistry of arsenic detoxification | Q34922203 | ||
| An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae | Q37713114 | ||
| A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance | Q38288677 | ||
| Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. | Q38297880 | ||
| Membrane association of glutathione S-transferase mGSTA4-4, an enzyme that metabolizes lipid peroxidation products | Q39586133 | ||
| Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects. | Q40573414 | ||
| Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog | Q40803174 | ||
| Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport | Q40816606 | ||
| New mechanisms of drug resistance in parasitic protozoa | Q40945183 | ||
| ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. | Q40962980 | ||
| ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids | Q41204983 | ||
| Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport | Q41204990 | ||
| Glutathione S-transferase pi facilitates the excretion of arsenic from arsenic-resistant Chinese hamster ovary cells | Q41553883 | ||
| Glutathione S-transferase pi in an arsenic-resistant Chinese hamster ovary cell line | Q41589397 | ||
| Arsenate Reduction in Human Erythrocytes and Rats--Testing the Role of Purine Nucleoside Phosphorylase | Q42440733 | ||
| Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae. | Q42619754 | ||
| ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump | Q42981150 | ||
| Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). | Q43002793 | ||
| The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase. | Q43578165 | ||
| Arsenate reductase II. Purine nucleoside phosphorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems | Q43998876 | ||
| Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity | Q44108486 | ||
| Purine nucleoside phosphorylase as a cytosolic arsenate reductase | Q44186169 | ||
| Structural requirements for functional interaction of glutathione tripeptide analogs with the human multidrug resistance protein 1 (MRP1). | Q44285538 | ||
| Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1). | Q44430387 | ||
| Oxidation and detoxification of trivalent arsenic species | Q44652900 | ||
| Polymorphisms in the human monomethylarsonic acid (MMA V) reductase/hGSTO1 gene and changes in urinary arsenic profiles | Q44696763 | ||
| Formation and urinary excretion of arsenic triglutathione and methylarsenic diglutathione | Q44766396 | ||
| Mutations of charged amino acids in or near the transmembrane helices of the second membrane spanning domain differentially affect the substrate specificity and transport activity of the multidrug resistance protein MRP1 (ABCC1). | Q44904900 | ||
| Role of the Multidrug Resistance Protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice | Q45713478 | ||
| Glutathione-dependent biliary excretion of arsenic | Q45777659 | ||
| Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins | Q48051232 | ||
| In vitro inhibition of glutathione reductase by arsenotriglutathione | Q49271013 | ||
| Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein. | Q54095422 | ||
| P433 | issue | 31 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | multiple drug resistance | Q643839 |
| P304 | page(s) | 32700-32708 | |
| P577 | publication date | 2004-05-25 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required | |
| P478 | volume | 279 |
| Q35651816 | A case-control study of GST polymorphisms and arsenic related skin lesions |
| Q36029266 | A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire |
| Q36768351 | Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic |
| Q36174255 | Altered arsenic disposition in experimental nonalcoholic fatty liver disease |
| Q37486703 | Anticancer activity of small-molecule and nanoparticulate arsenic(III) complexes. |
| Q38817887 | Arsenic Induction of Metallothionein and Metallothionein Induction Against Arsenic Cytotoxicity |
| Q38764633 | Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23. |
| Q55362655 | Arsenic Trioxide Enhances the NK Cell Cytotoxicity Against Acute Promyelocytic Leukemia While Simultaneously Inhibiting Its Bio-Genesis. |
| Q35866055 | Arsenic and antimony transporters in eukaryotes |
| Q28387404 | Arsenic and cardiovascular disease |
| Q51805856 | Arsenic and cigarette smoke synergistically increase DNA oxidation in the lung. |
| Q37987437 | Arsenic metabolism and thioarsenicals. |
| Q34397208 | Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters |
| Q34397249 | Arsenic tolerance in plants: “Pas de deux” between phytochelatin synthesis and ABCC vacuolar transporters |
| Q39809282 | Arsenic trioxide inhibits the growth of adriamycin resistant osteosarcoma cells through inducing apoptosis. |
| Q34593837 | Arsenic, Stem Cells, and the Developmental Basis of Adult Cancer |
| Q37145891 | Arsenic-based antineoplastic drugs and their mechanisms of action |
| Q33828693 | Arsenic-specific stem cell selection during malignant transformation |
| Q37436028 | Arsenite transport in plants. |
| Q54993548 | Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway. |
| Q34599279 | Catalase activity and arsenic sensitivity in acute leukemia. |
| Q57610278 | Chapter 5 Inorganic Molecular Toxicology and Chelation Therapy of Heavy Metals and Metalloids |
| Q37149737 | Chronic arsenic exposure and blood glutathione and glutathione disulfide concentrations in Bangladeshi adults |
| Q35230758 | Comparison of newly diagnosed and relapsed patients with acute promyelocytic leukemia treated with arsenic trioxide: insight into mechanisms of resistance |
| Q41847628 | Contribution of aquaporin 9 and multidrug resistance-associated protein 2 to differential sensitivity to arsenite between primary cultured chorion and amnion cells prepared from human fetal membranes |
| Q28565021 | Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier |
| Q38763381 | Cortical Astrocytes Acutely Exposed to the Monomethylarsonous Acid (MMAIII) Show Increased Pro-inflammatory Cytokines Gene Expression that is Consistent with APP and BACE-1: Over-expression |
| Q37008886 | Drug transport across the placenta, role of the ABC drug efflux transporters |
| Q92243530 | Effects of Proanthocyanidins on Arsenic Methylation Metabolism and Efflux in Human Hepatocytes L-02 |
| Q52741796 | Efflux of glutathione and glutathione complexes from human erythrocytes in response to inorganic arsenic exposure. |
| Q28238144 | Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line |
| Q33653912 | Enhanced glutathione biosynthetic capacity promotes resistance to As3+-induced apoptosis |
| Q37085878 | Enhancing the efficacy of cisplatin in ovarian cancer treatment - could arsenic have a role. |
| Q37969214 | Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics |
| Q36468922 | Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells |
| Q91992770 | Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity |
| Q36546222 | Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. |
| Q25256866 | Global gene expression associated with hepatocarcinogenesis in adult male mice induced by in utero arsenic exposure |
| Q48214407 | Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme. |
| Q42463468 | High accumulation of arsenic in the esophagus of mice after exposure to arsenite. |
| Q37141217 | Hijacking microglial glutathione by inorganic arsenic impels bystander death of immature neurons through extracellular cystine/glutamate imbalance. |
| Q35684516 | Identification of the GST-T1 and GST-M1 null genotypes using high resolution melting analysis |
| Q50524066 | Individual variations in arsenic metabolism in Vietnamese: the association with arsenic exposure and GSTP1 genetic polymorphism. |
| Q38402177 | Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism |
| Q28383469 | Inorganic arsenic and human prostate cancer |
| Q36744214 | Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells |
| Q37091529 | Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase |
| Q50910807 | MRP1 expression in bronchoalveolar lavage cells in subjects with lung cancer who were chronically exposed to arsenic. |
| Q33554403 | MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer |
| Q27499027 | Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior |
| Q36628920 | Metabolism and toxicity of arsenic in human urothelial cells expressing rat arsenic (+3 oxidation state)-methyltransferase. |
| Q38027433 | Metabolism of arsenic and its toxicological relevance |
| Q33618916 | Metabolism, toxicity and anticancer activities of arsenic compounds |
| Q28387251 | Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure |
| Q28397241 | Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic |
| Q42675381 | Molecular analysis and heavy metal detoxification of ABCC1/MRP1 in zebrafish |
| Q36104172 | Molecular and ionic mimicry and the transport of toxic metals. |
| Q42715412 | Multidrug resistance protein 1 (ABCC1) confers resistance to arsenic compounds in human myeloid leukemic HL-60 cells. |
| Q46646759 | Multidrug resistance-associated protein 4 is a determinant of arsenite resistance. |
| Q57649750 | Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress |
| Q35163743 | Nitric oxide donor, V-PROLI/NO, provides protection against arsenical induced toxicity in rat liver cells: requirement for Cyp1a1 |
| Q35802014 | Nitrogen monoxide (NO) storage and transport by dinitrosyl-dithiol-iron complexes: long-lived NO that is trafficked by interacting proteins |
| Q34650693 | Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1. |
| Q37029787 | Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity |
| Q39213570 | Oxidative DNA damage after acute exposure to arsenite and monomethylarsonous acid in biomethylation-deficient human cells |
| Q38958745 | Placental ABC Transporters: Biological Impact and Pharmaceutical Significance |
| Q39564458 | Rat H9c2 cardiac myocytes are sensitive to arsenite due to a modest activation of transcription factor Nrf2. |
| Q39078405 | Redirecting apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels, and VDAC. |
| Q37478021 | Requirement of arsenic biomethylation for oxidative DNA damage |
| Q39687479 | Selenium-dependent and -independent transport of arsenic by the human multidrug resistance protein 2 (MRP2/ABCC2): implications for the mutual detoxification of arsenic and selenium |
| Q36775161 | Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest. |
| Q33940195 | Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC) |
| Q35892810 | Sodium arsenite ± hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses |
| Q37707907 | Strain differences in arsenic-induced oxidative lesion via arsenic biomethylation between C57BL/6J and 129X1/SvJ mice |
| Q46974689 | Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes |
| Q33657470 | The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. |
| Q37633312 | The putative multidrug resistance protein MRP-7 inhibits methylmercury-associated animal toxicity and dopaminergic neurodegeneration in Caenorhabditis elegans |
| Q43098281 | Toxicity of Glutathione-Binding Metals: A Review of Targets and Mechanisms |
| Q33354347 | Transcriptomic changes and signalling pathways induced by arsenic stress in rice roots |
| Q36525551 | Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins |
| Q51097442 | Transport of antimony salts by Arabidopsis thaliana protoplasts over-expressing the human multidrug resistance-associated protein 1 (MRP1/ABCC1). |
| Q46661470 | Ultrastructural localization and chemical binding of silver ions in human organotypic skin cultures |
| Q36544962 | Use of in vitro transporter assays to understand hepatic and renal disposition of new drug candidates |
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