The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents

scientific article published on August 1997

The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.17.8.4792
P932PMC publication ID232331
P698PubMed publication ID9234735

P2093author name stringBender K
Angel P
Wilhelm D
Knebel A
P2860cites workSignal transduction by tumor necrosis factor mediated by JNK protein kinasesQ24308037
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domainQ24308838
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoformsQ24312029
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2Q24313872
Selective interaction of JNK protein kinase isoforms with transcription factorsQ24317346
Activation of Pyk2 by stress signals and coupling with JNK signaling pathwayQ24323778
Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoproteinQ24555703
The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphataseQ24561826
ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agentsQ24568306
ATF-2 contains a phosphorylation-dependent transcriptional activation domainQ24568315
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1Q28114883
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activationQ28131755
Activation of ternary complex factor Elk-1 by stress-activated protein kinasesQ28272395
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonineQ28287650
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1Q28291340
Lysophosphatidic acid, a multifunctional phospholipid messengerQ28302384
Transcription factor ATF2 regulation by the JNK signal transduction pathwayQ28305631
Evidence for multiple activators for stress-activated protein kinase/c-Jun amino-terminal kinases. Existence of novel activatorsQ28576079
ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivationQ28578241
MAPKs: new JNK expands the groupQ28611010
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformationQ29400446
Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42HsQ29547308
An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1Q29614256
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathwayQ29614258
The stress-activated protein kinase subfamily of c-Jun kinasesQ29620001
Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells. A correlation with different ethylation products in DNAQ70596611
Selective modification of glutathione metabolismQ71695892
Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibitionQ71743487
Glutathione can rescue the inhibitory effects of nickel on DNA ligation and repair synthesisQ71988369
Roles for oxidative stress and poly(ADP-ribosyl)ation in the killing of cultured hepatocytes by methyl methanesulfonateQ72632996
69 Methods for enucleation and reconstruction of interferon-producing cellsQ72657621
Involvement of growth factor receptors in the mammalian UVC responseQ72710815
Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinaseQ72724630
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-JunQ29620103
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domainQ29620169
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKKQ29620274
Autocrine transformation by chimeric signal peptide-basic fibroblast growth factor: reversal by suraminQ33687824
Phosphorylation of c-jun mediated by MAP kinases.Q34947174
Rapid and preferential activation of the c-jun gene during the mammalian UV responseQ36693305
Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expressionQ36757863
Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73Q36821325
Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapyQ36936660
Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.Q37334431
Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suraminQ37397266
Response to adversity: molecular control of gene activation following genotoxic stressQ37422748
Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.Q37625844
The chemical effects of nucleic acid alkylation and their relation to mutagenesis and carcinogenesisQ38111405
UV irradiation and heat shock mediate JNK activation via alternate pathways.Q38289506
JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimersQ38321318
Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A proteinQ38322155
Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1.Q40017118
Lysophosphatidic acid signallingQ40444988
Rho family members: Activators of MAP kinase cascadesQ40476489
A review of the genotoxicity of 1-ethyl-1-nitrosoureaQ40487875
Growth factor-like effects of lysophosphatidic acid, a novel lipid mediator.Q40567927
Fos is an essential component of the mammalian UV responseQ40789823
UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinaseQ40872239
Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agentsQ41077480
Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathwayQ41226993
Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activationQ41269491
Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agentsQ41307866
Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. Implications for the mechanism of autocrine transformationQ41336412
Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-junQ41431597
c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK.Q41442860
Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoterQ41612990
Alkylation of protein by methyl methanesulfonate and 1-methyl-1-nitrosourea in vitroQ42247067
Three distinct signalling responses by murine fibroblasts to genotoxic stressQ42807014
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73Q42825163
Preventive action of thioethers towards in vitro DNA binding and mutagenesis in E. coli K12 by alkylating agentsQ45085447
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.Q45971622
Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agentsQ46067039
An osmosensing signal transduction pathway in mammalian cellsQ48080102
A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography.Q53576351
Cellular glutathione (GSH) and glutathione S-transferase (GST) activity in human ovarian tumor biopsies following exposure to alkylating agentsQ54280548
Integration of MAP kinase signal transduction pathways at the serum response elementQ58415341
The mammalian ultraviolet response is triggered by activation of src tyrosine kinasesQ60621256
A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in cultureQ62555340
The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agentsQ66919004
Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the responseQ68093019
The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acidQ69353201
Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukaemic cellsQ70545093
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectglutathioneQ116907
P304page(s)4792-4800
P577publication date1997-08-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThe level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents
P478volume17

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