Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

scientific article published on August 31, 1995

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1022545215
P356DOI10.1038/376785A0
P953full work available online athttp://www.nature.com/articles/376785a0
http://www.nature.com/articles/376785a0.pdf
P698PubMed publication ID7651539

P2093author name stringP. Pandey
D. W. Kufe
R. R. Weichselbaum
S. Kharbanda
R. Ren
S. M. Feller
T. D. Shafman
P2860cites workStructural aspects of platinum anticancer drug interactions with DNAQ60174164
Mechanism of monofunctional and bifunctional alkylation of DNA by mitomycin CQ70394741
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domainQ24308838
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycleQ24319785
c-Abl kinase regulates the protein binding activity of c-CrkQ24595669
Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sitesQ28238659
SH2 and SH3 domains as molecular adhesives: the interactions of Crk and AblQ28307277
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogeneQ28512170
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell lineQ29547239
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
Catalytic specificity of protein-tyrosine kinases is critical for selective signallingQ29616451
The stress-activated protein kinase subfamily of c-Jun kinasesQ29620001
Phosphorylation of c-jun mediated by MAP kinases.Q34947174
The nuclear tyrosine kinase c-Abl negatively regulates cell growthQ42799874
Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.Q46008782
Cell cycle-regulated binding of c-Abl tyrosine kinase to DNAQ46126062
The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammalsQ46508406
P433issue6543
P407language of work or nameEnglishQ1860
P921main subjectmitogen-activated protein kinase kinasesQ6593810
mitogen-activated protein (MAP) kinase, JNKQ24774703
P304page(s)785-788
P577publication date1995-08-01
1995-08-31
P1433published inNatureQ180445
P1476titleActivation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents
Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents
P478volume376

Reverse relations

cites work (P2860)
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Q24305397Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity
Q37549839Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice
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Q40932936Protein tyrosine kinase Lyn mediates apoptosis induced by topoisomerase II inhibitors in DT40 cells
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Q33765328Regulated phosphorylation of the RNA polymerase II C-terminal domain (CTD).
Q41659032Regulation and function of the JNK subgroup of MAP kinases
Q24320206Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase
Q30176052Regulation of DNA-dependent Protein Kinase by the Lyn Tyrosine Kinase
Q24336551Regulation of Rad51 Function by c-Abl in Response to DNA Damage
Q34103653Regulation of cell death by the Abl tyrosine kinase
Q24652254Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts
Q40751506Regulation of p73 by c-Abl through the p38 MAP kinase pathway.
Q43075879Regulation of p73-mediated apoptosis by c-Jun N-terminal kinase
Q33601067Regulation of the DNA-dependent protein kinase (DNA-PK) activity in eukaryotic cells.
Q39424924Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Q64388536Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase
Q28141152Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase
Q36042664Relevance of atypical protein kinase C isotypes to the drug discovery process
Q54663743Requirement for caspase activation in monocytic differentiation of myeloid leukemia cells
Q42833330Requirement of caspase-mediated cleavage of c-Abl during stress-induced apoptosis
Q33755493Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.
Q40802404Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype.
Q83524944Resveratrol Improves Hippocampal Atrophy in Chronic Fatigue Mice by Enhancing Neurogenesis and Inhibiting Apoptosis of Granular Cells
Q44151433Retinoblastoma protein-mediated apoptosis after gamma-irradiation
Q40732586Reversal of cisplatin resistance in human ovarian cancer cell lines by a c-jun antisense oligodeoxynucleotide (ISIS 10582): evidence for the role of transcription factor overexpression in determining resistant phenotype
Q26782005Rho GTPases: Novel Players in the Regulation of the DNA Damage Response?
Q22254596Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage
Q41183906Role for c-Abl tyrosine kinase in growth arrest response to DNA damage.
Q33957777Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage
Q77800919Role for p300 in stabilization of p53 in the response to DNA damage
Q28396643Role of ABL family kinases in cancer: from leukaemia to solid tumours
Q43559235Role of ATM in oxidative stress-mediated c-Jun phosphorylation in response to ionizing radiation and CdCl2.
Q36919677Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation
Q34333852Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells
Q35910747Role of DNA mismatch repair in apoptotic responses to therapeutic agents
Q30164884Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response
Q41515342Role of p53 in apoptosis.
Q42527540Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs
Q46857265Roles of volume-sensitive Cl- channel in cisplatin-induced apoptosis in human epidermoid cancer cells
Q44414169SEK1-dependent JNK1 activation prolongs cell survival during G-Rh2-induced apoptosis
Q35615838SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl
Q46784050SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively
Q34310555Shared pathways: death receptors and cytotoxic drugs in cancer therapy
Q41750250Signal Transduction through MAP Kinase Cascades
Q41679375Signal transduction by wild-type and leukemogenic Abl proteins.
Q41228964Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death
Q41106742Sounding the alarm: protein kinase cascades activated by stress and inflammation
Q40142360Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis
Q28307140Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)
Q39676953Sunitinib improves chemotherapeutic efficacy and ameliorates cisplatin-induced nephrotoxicity in experimental animals
Q40664009Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells
Q41133285Syk-dependent and -independent signaling cascades in B cells elicited by osmotic and oxidative stress.
Q21146439T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression
Q37286884TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation
Q53453867TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress
Q35782893Targeting mutated tyrosine kinases in the therapy of myeloid leukaemias
Q28572770Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis
Q28207630The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress
Q28206550The Abl family kinases: mechanisms of regulation and signaling
Q40876650The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells
Q40023085The Level of Intracellular Glutathione Is a Key Regulator for the Induction of Stress-Activated Signal Transduction Pathways Including Jun N-Terminal Protein Kinases and p38 Kinase by Alkylating Agents
Q24606662The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity
Q47096280The Role of MDM2 in Promoting Genome Stability versus Instability.
Q34979711The activity and stability of the intrinsically disordered Cip/Kip protein family are regulated by non-receptor tyrosine kinases
Q24649024The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation
Q41751646The c-Abl tyrosine kinase contributes to the transient activation of MAP kinase in cells plated on fibronectin
Q28508496The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products
Q37173931The effects of c-Abl mutation on developing B cell differentiation and survival
Q22254262The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death
Q40963201The presence of the Rb c-box peptide in the cytoplasm inhibits p210bcr-abl transforming function
Q28611462The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis
Q30176902The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.
Q41200518The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat
Q22010200The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
Q42807014Three distinct signalling responses by murine fibroblasts to genotoxic stress
Q59054090Three paths to stress relief
Q34616111Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells
Q38994070Trace levels of mitomycin C disrupt genomic integrity and lead to DNA damage response defect in long-term-cultured human embryonic stem cells
Q28585350Two distinct phosphorylation pathways have additive effects on Abl family kinase activation
Q34658532Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease
Q24318110Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding.
Q24534983Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation
Q39723274UV sensitivity and impaired nucleotide excision repair in DNA-dependent protein kinase mutant cells.
Q41356307UV-induced signal transduction
Q45286153Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress
Q73668859Ultraviolet light attenuates heat-inducible gene expression
Q46130853Underlying protective mechanism of α1-adrenoceptor activation against irradiation-induced damage in rat submandibular gland
Q38122944Vitamin B2: A promising adjuvant in cisplatin based chemoradiotherapy by cellular redox management
Q24318820Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution
Q35037461Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein
Q40076507c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy.
Q42819017c-Abl activation regulates induction of the SEK1/stress-activated protein kinase pathway in the cellular response to 1-beta-D-arabinofuranosylcytosine
Q42588123c-Abl downregulates the slow phase of double-strand break repair
Q37897502c-Abl in Neurodegenerative Disease
Q28511871c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency
Q28573299c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP
Q39460833c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination
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