| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | M Karin | |
| A Minden | |||
| P2860 | cites work | Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase | Q24303413 |
| Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions | Q24307776 | ||
| Signal transduction by tumor necrosis factor mediated by JNK protein kinases | Q24308037 | ||
| JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain | Q24308838 | ||
| Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways | Q24309037 | ||
| Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity | Q24309185 | ||
| Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade | Q24309299 | ||
| A new group of conserved coactivators that increase the specificity of AP-1 transcription factors | Q24310680 | ||
| A protein kinase involved in the regulation of inflammatory cytokine biosynthesis | Q24311139 | ||
| ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation | Q24312012 | ||
| Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms | Q24312029 | ||
| Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2 | Q24313872 | ||
| Selective interaction of JNK protein kinase isoforms with transcription factors | Q24317346 | ||
| Components of a new human protein kinase signal transduction pathway | Q24319086 | ||
| Regulatory role of MEF2D in serum induction of the c-jun promoter | Q24319672 | ||
| A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase | Q24321458 | ||
| Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta) | Q24321919 | ||
| Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway | Q24323015 | ||
| Activation of Pyk2 by stress signals and coupling with JNK signaling pathway | Q24323778 | ||
| Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2 | Q24336357 | ||
| Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase | Q24336591 | ||
| Characterization of the structure and function of a novel MAP kinase kinase (MKK6) | Q24336966 | ||
| NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain | Q24532124 | ||
| Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor | Q24561804 | ||
| Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein | Q24564025 | ||
| Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells | Q24564451 | ||
| ATF-2 contains a phosphorylation-dependent transcriptional activation domain | Q24568315 | ||
| MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway | Q24650627 | ||
| Mammalian Ras interacts directly with the serine/threonine kinase Raf | Q27860833 | ||
| The small GTP-binding protein rac regulates growth factor-induced membrane ruffling | Q27861063 | ||
| Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia | Q27861126 | ||
| A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C. | Q27930780 | ||
| An osmosensing signal transduction pathway in yeast. | Q27932086 | ||
| MAP kinase pathways in yeast: for mating and more | Q27938176 | ||
| Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1 | Q28114883 | ||
| Raf-1 activates MAP kinase-kinase | Q28211351 | ||
| Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro | Q28211916 | ||
| A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells | Q28237789 | ||
| JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation | Q28243308 | ||
| A brain serine/threonine protein kinase activated by Cdc42 and Rac1 | Q28249559 | ||
| A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf | Q28263195 | ||
| A role for Rho in Ras transformation | Q33723020 | ||
| The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation | Q33767307 | ||
| jun-D: a third member of the jun gene family | Q33839734 | ||
| Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. | Q34061286 | ||
| A role for Rac in Tiam1-induced membrane ruffling and invasion | Q34310851 | ||
| Multiple Ras functions can contribute to mammalian cell transformation | Q34319284 | ||
| Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases | Q34339820 | ||
| ERK3 is a constitutively nuclear protein kinase | Q34378048 | ||
| Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation | Q34419537 | ||
| Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction | Q34733274 | ||
| Phosphorylation of c-jun mediated by MAP kinases. | Q34947174 | ||
| Receptor tyrosine kinases | Q35225814 | ||
| The serum response element | Q35557503 | ||
| The mitogen-activated protein kinase activator | Q35659756 | ||
| The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction | Q36332163 | ||
| Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24. | Q36554962 | ||
| GTPase-deficient G alpha 16 and G alpha q induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinases | Q36557162 | ||
| Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases | Q28279211 | ||
| Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF | Q28283139 | ||
| Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase | Q28283499 | ||
| Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family | Q28289551 | ||
| The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1 | Q28291340 | ||
| The gene lin-3 encodes an inductive signal for vulval development in C. elegans | Q28291552 | ||
| c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions | Q28298557 | ||
| Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes | Q28300854 | ||
| Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3 | Q28301735 | ||
| Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins | Q28303508 | ||
| The activation of phosphatidylinositol 3-kinase by Ras | Q28305326 | ||
| Transcription factor ATF2 regulation by the JNK signal transduction pathway | Q28305631 | ||
| Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain | Q28573164 | ||
| ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation | Q28578241 | ||
| Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation | Q28609129 | ||
| Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2 | Q28609817 | ||
| Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs | Q29547308 | ||
| Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis | Q29547567 | ||
| The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts | Q29614253 | ||
| An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1 | Q29614256 | ||
| The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway | Q29614258 | ||
| Use of an oriented peptide library to determine the optimal substrates of protein kinases | Q29614792 | ||
| CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae | Q29616588 | ||
| Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras | Q29617087 | ||
| A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins | Q29617438 | ||
| Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells | Q29618480 | ||
| Transformation of mammalian cells by constitutively active MAP kinase kinase | Q29618686 | ||
| The stress-activated protein kinase subfamily of c-Jun kinases | Q29620001 | ||
| Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death | Q29620021 | ||
| Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun | Q29620103 | ||
| Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain | Q29620169 | ||
| Phosphatidylinositol-3-OH kinase as a direct target of Ras | Q29620177 | ||
| The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain | Q29620270 | ||
| Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK | Q29620274 | ||
| SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1 | Q29620495 | ||
| The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. | Q30176864 | ||
| SH2/SH3 signaling proteins | Q30194539 | ||
| Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate | Q30464735 | ||
| A gene activated by growth factors is related to the oncogene v-jun | Q33556740 | ||
| Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways | Q42807426 | ||
| Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade | Q42807716 | ||
| Functional analysis of a growth factor-responsive transcription factor complex | Q42810320 | ||
| Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73 | Q42825163 | ||
| An essential role for Rac in Ras transformation | Q42829150 | ||
| Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway. | Q42829329 | ||
| PHAS-I as a link between mitogen-activated protein kinase and translation initiation | Q42833060 | ||
| Induction of proto-oncogene JUN/AP-1 by serum and TPA. | Q43487125 | ||
| Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha | Q43819767 | ||
| A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans | Q45065055 | ||
| NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. | Q45971622 | ||
| Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. | Q45988406 | ||
| Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. | Q46027909 | ||
| Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors | Q46175993 | ||
| Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene | Q46719495 | ||
| Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun | Q46914063 | ||
| Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation | Q47068838 | ||
| A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila | Q47070626 | ||
| A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways | Q47070874 | ||
| The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. | Q47071054 | ||
| An osmosensing signal transduction pathway in mammalian cells | Q48080102 | ||
| Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals | Q50335838 | ||
| Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva. | Q52236554 | ||
| Association of the Yeast Pheromone Response G Protein βγ Subunits with the Map Kinase Scaffold Ste5p | Q54841659 | ||
| c-Jun is essential for normal mouse development and hepatogenesis | Q57083732 | ||
| Integration of MAP kinase signal transduction pathways at the serum response element | Q58415341 | ||
| Three paths to stress relief | Q59054090 | ||
| Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts | Q60188707 | ||
| A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture | Q62555340 | ||
| Pleiotropic effects of a null mutation in the c-fos proto-oncogene | Q62555352 | ||
| Different requirements for formation of Jun: Jun and Jun: Fos complexes | Q69274554 | ||
| Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation | Q72167517 | ||
| Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo | Q73039178 | ||
| Increasing cAMP attenuates activation of mitogen-activated protein kinase | Q36645860 | ||
| c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases | Q36667357 | ||
| Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras | Q36667927 | ||
| Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro | Q36679396 | ||
| Rapid and preferential activation of the c-jun gene during the mammalian UV response | Q36693305 | ||
| Extracellular signal-regulated kinases: ERKs in progress | Q36746413 | ||
| Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Far1. | Q36756449 | ||
| Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter | Q36762038 | ||
| Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73 | Q36821325 | ||
| SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases | Q36833340 | ||
| Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. | Q37625844 | ||
| The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. | Q37630688 | ||
| Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets | Q38289451 | ||
| UV irradiation and heat shock mediate JNK activation via alternate pathways. | Q38289506 | ||
| The DNA binding activity of C/EBP transcription factor is regulated in the G1 phase of the hepatocyte cell cycle | Q38293198 | ||
| Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways | Q38354870 | ||
| Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. | Q39481540 | ||
| The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily | Q39753280 | ||
| Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1. | Q40017118 | ||
| Angiotensin II stimulates calcium-dependent activation of c-Jun N-terminal kinase | Q40017552 | ||
| The proliferation of MAP kinase signaling pathways in yeast. | Q40444983 | ||
| Parallel signal processing among mammalian MAPKs | Q40501929 | ||
| Ras pathways in Caenorhabditis elegans | Q40525087 | ||
| The Ras signaling pathway in Drosophila | Q40525097 | ||
| MAP kinase kinase kinase, MAP kinase kinase and MAP kinase | Q40757575 | ||
| Ternary complex factors: growth factor regulated transcriptional activators | Q40757584 | ||
| Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila | Q40766029 | ||
| Molecular mechanisms of developmental neuronal death | Q40890833 | ||
| Prostaglandin synthase 2. | Q40941854 | ||
| Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms | Q40971614 | ||
| Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast | Q40974442 | ||
| The regulation of AP-1 activity by mitogen-activated protein kinases | Q40998182 | ||
| Protein kinase cascades activated by stress and inflammatory cytokines | Q41075765 | ||
| The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light. | Q41078766 | ||
| MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6 | Q41079070 | ||
| Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway | Q41134913 | ||
| RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase | Q41150493 | ||
| p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient | Q41179859 | ||
| Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac. | Q41183644 | ||
| JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells | Q41202424 | ||
| Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. | Q41218044 | ||
| Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway | Q41226993 | ||
| Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death | Q41228964 | ||
| Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis | Q41239719 | ||
| Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells | Q41257915 | ||
| Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation | Q41269491 | ||
| Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1 | Q41283042 | ||
| Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents | Q41307866 | ||
| Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13 | Q41313401 | ||
| Differential calcium dependence in the activation of c-Jun kinase and mitogen-activated protein kinase by muscarinic acetylcholine receptors in rat 1a cells | Q41325304 | ||
| Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association | Q41346200 | ||
| Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. | Q41461695 | ||
| Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity | Q41603774 | ||
| Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter | Q41612990 | ||
| Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor | Q41978360 | ||
| Mechanism of inhibition of Raf-1 by protein kinase A. | Q42030118 | ||
| Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases | Q42804655 | ||
| Three distinct signalling responses by murine fibroblasts to genotoxic stress | Q42807014 | ||
| P433 | issue | 2 | |
| P304 | page(s) | F85-104 | |
| P577 | publication date | 1997-10-01 | |
| P1433 | published in | Biochimica et Biophysica Acta | Q864239 |
| P1476 | title | Regulation and function of the JNK subgroup of MAP kinases | |
| P478 | volume | 1333 |
| Q51767975 | 3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Inhibits Collagenase Activity and Induces Type I Procollagen Synthesis in HDFn Cells. |
| Q35990028 | A conserved role of IQGAP1 in regulating TOR complex 1 |
| Q38103727 | A molecular rheostat at the interface of cancer and diabetes |
| Q93038072 | ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model |
| Q48421838 | Activated c-Jun N-terminal kinase is required for axon formation. |
| Q33964540 | Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage |
| Q38329782 | Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1. |
| Q33793056 | Activation of the mitogen-activated protein kinase p38 by human cytomegalovirus infection through two distinct pathways: a novel mechanism for activation of p38. |
| Q41345748 | Alternative promotion and suppression of metastasis by JNK2 governed by its phosphorylation |
| Q39670510 | Anti-inflammatory Activity of n-Propyl Gallate Through Down-regulation of NF-κB and JNK Pathways |
| Q38832848 | Bee Venom Protects against Rotenone-Induced Cell Death in NSC34 Motor Neuron Cells |
| Q38531952 | Biliverdin reductase: a target for cancer therapy? |
| Q42587729 | Biliverdin reductase: more than a namesake - the reductase, its Peptide fragments, and biliverdin regulate activity of the three classes of protein kinase C |
| Q42467906 | Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone |
| Q40750201 | C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP. |
| Q33940793 | CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells |
| Q34301824 | Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38 |
| Q26778537 | Cellular Response upon Stress: p57 Contribution to the Final Outcome |
| Q48646698 | Chronic isolation stress compromises JNK/c-Jun signaling in rat brain |
| Q54729669 | Cranberry proanthocyanidins inhibit MMP production and activity. |
| Q40733134 | Cytoplasmic aggregation of TRAF2 and TRAF5 proteins in the Hodgkin-Reed-Sternberg cells |
| Q28188291 | Cytostatic p21 G protein-activated protein kinase gamma-PAK |
| Q28509000 | Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice |
| Q30322144 | Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice |
| Q37038464 | Dendritic cells and contact dermatitis |
| Q33960372 | Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation |
| Q35216258 | Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor |
| Q46841043 | Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression |
| Q40424092 | Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites |
| Q35044880 | Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells |
| Q39043673 | Efficient keratinocyte differentiation strictly depends on JNK-induced soluble factors in fibroblasts |
| Q39528509 | Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress |
| Q33605331 | Environmental factors as regulators and effectors of multistep carcinogenesis |
| Q40550738 | Epidermal growth factor enhances cellular TATA binding protein levels and induces RNA polymerase I- and III-dependent gene activity |
| Q36736233 | Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. |
| Q35169193 | Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression |
| Q28512556 | Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain |
| Q84582498 | Expression of MMP-9 and WAVE3 in colorectal cancer and its relationship to clinicopathological features |
| Q43637080 | Expression of ring finger-deleted TRAF2 sensitizes metastatic melanoma cells to apoptosis via up-regulation of p38, TNFalpha and suppression of NF-kappaB activities |
| Q36368794 | Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes. |
| Q35668827 | Formation of ternary complex of human biliverdin reductase-protein kinase Cδ-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-κB, and inducible nitric-oxidase synthase (iNOS). |
| Q39975306 | FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness |
| Q42793400 | Furano‐1,2‐naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells |
| Q36819372 | G protein regulation of MAPK networks |
| Q36346927 | Gankyrin drives malignant transformation of chronic liver damage-mediated fibrosis via the Rac1/JNK pathway |
| Q42812461 | Gas6-mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of Ras. |
| Q30918621 | Glucocorticoids antagonize AP-1 by inhibiting the Activation/phosphorylation of JNK without affecting its subcellular distribution |
| Q33585517 | Glucotoxicity induces abnormal glucagon secretion through impaired insulin signaling in InR1G cells |
| Q34478838 | Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase |
| Q39647641 | Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38 |
| Q89820673 | Heme-Derived Metabolic Signals Dictate Immune Responses |
| Q45729140 | Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase |
| Q41093360 | High WAVE3 expression correlates with proliferation, migration and invasion in human ovarian cancer |
| Q34271504 | Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase |
| Q36657552 | Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling |
| Q33799921 | Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression |
| Q34038093 | Hyperthermia differently affects connexin43 expression and gap junction permeability in skeletal myoblasts and HeLa cells. |
| Q36938538 | Identification of a new JNK inhibitor targeting the JNK-JIP interaction site |
| Q36324389 | Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities |
| Q42496484 | Immunohistochemical study on the expression of c-Fos and c-Jun in human skin wounds. |
| Q24654047 | Induction of apoptosis in human leukemia cells by grape seed extract occurs via activation of c-Jun NH2-terminal kinase |
| Q33877098 | Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells. |
| Q39448079 | Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways |
| Q40442292 | Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells |
| Q33943930 | Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells |
| Q33962291 | Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner |
| Q47300666 | Inhibition of host extracellular matrix destructive enzyme production and activity by a high-molecular-weight cranberry fraction |
| Q24530620 | Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase |
| Q24540351 | JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. |
| Q42481763 | JNK and c-Jun but not ERK and c-Fos are associated with sustained neointima-formation after balloon injury |
| Q22010669 | JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway |
| Q34279331 | Jun, the oncoprotein. |
| Q36900733 | Kinase cascades and ligand-directed signaling at the kappa opioid receptor |
| Q28213774 | Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes |
| Q36984681 | Lipopolysaccharide stimulation of trophoblasts induces corticotropin-releasing hormone expression through MyD88 |
| Q33886039 | Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development |
| Q34770928 | Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation |
| Q44615992 | MAPK pathways mediate hyperoxia-induced oncotic cell death in lung epithelial cells |
| Q42824944 | Macrophage migration inhibitory factor does not modulate co-activation of androgen receptor by Jab1/CSN5. |
| Q33415468 | Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation |
| Q37061820 | Mitogenic Effect of Orphan Receptor TR3 and Its Regulation by MEKK1 in Lung Cancer Cells |
| Q58113198 | Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death |
| Q41707732 | Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition |
| Q38310747 | Modulation of interleukin-1beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes. |
| Q33416210 | Molecular mechanisms of cell proliferation induced by low power laser irradiation |
| Q36974487 | Molecular mechanisms of opioid receptor-dependent signaling and behavior |
| Q35186927 | Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase |
| Q46575209 | Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole-blood models |
| Q36360349 | Negative regulation of the SAPK/JNK signaling pathway by presenilin 1 |
| Q35844017 | Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation |
| Q35102215 | Nontranscriptional actions of the glucocorticoid receptor. |
| Q34063426 | Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway |
| Q30453600 | Novel membrane-targeted ERK1 and ERK2 chimeras which act as dominant negative, isotype-specific mitogen-activated protein kinase inhibitors of Ras-Raf-mediated transcriptional activation of c-fos in NIH 3T3 cells |
| Q37343918 | Oxidized {alpha}1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema |
| Q35119337 | P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis |
| Q24540039 | PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells |
| Q34275177 | PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: Involvement of p38 mitogen activated protein kinase |
| Q43583425 | PKC delta mediates ionizing radiation-induced activation of c-Jun NH(2)-terminal kinase through MKK7 in human thyroid cells |
| Q58699564 | PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice |
| Q33945740 | Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene |
| Q77903807 | Pharmacological modulation of cytokine action and production through signaling pathways |
| Q28910198 | Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1 |
| Q35922200 | Protein kinase C δ (PKCδ)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia |
| Q39540080 | Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway |
| Q42951692 | Reduction in cadmium‐induced toxicity and c‐Jun N‐terminal kinase activation by glutathione in cultured mouse embryonic cells |
| Q34487811 | Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. |
| Q34111846 | Regulation of RANTES promoter activation in gastric epithelial cells infected with Helicobacter pylori |
| Q36375882 | Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation |
| Q28115804 | Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors |
| Q35584927 | Regulation of matrix metalloproteinases: an overview |
| Q43538143 | Retinoic acid inhibits transformation by preventing phosphatidylinositol 3-kinase dependent activation of the c-fos promoter. |
| Q54060350 | Role of TRAF2/GCK in melanoma sensitivity to UV-induced apoptosis. |
| Q22010147 | Role of the ATFa/JNK2 complex in Jun activation |
| Q37141782 | SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers |
| Q28344057 | Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines |
| Q36443644 | Serine-threonine protein kinase activation may be an effective target for reducing neuronal apoptosis after spinal cord injury |
| Q24554287 | Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation |
| Q40397936 | Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells |
| Q24799716 | The STATs in cell stress-type responses |
| Q39675100 | The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor |
| Q30175936 | The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway |
| Q28587209 | The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor |
| Q39699169 | The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein Bag-1. |
| Q39674326 | The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent. |
| Q36890002 | The role of stratifin in fibroblast-keratinocyte interaction |
| Q36376358 | The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. |
| Q30438150 | The subendothelial extracellular matrix modulates JNK activation by flow |
| Q33944243 | Therapy of B-cell malignancies by anti-HLA-DR humanized monoclonal antibody, IMMU-114, is mediated through hyperactivation of ERK and JNK MAP kinase signaling pathways |
| Q47575333 | Toll-Like Receptor-3 Mediates HIV-1-Induced Interleukin-6 Expression in the Human Brain Endothelium via TAK1 and JNK Pathways: Implications for Viral Neuropathogenesis. |
| Q34137394 | Transcriptional Enhancers in Animal Development and Evolution |
| Q28085631 | Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies |
| Q40802609 | UV-A-induced AP-1 activation requires the Raf/ERK pathway in human NCTC 2544 keratinocytes. |
| Q43002384 | Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein |
| Q33968015 | Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter |
| Q34000271 | YopJ of Yersinia spp. is sufficient to cause downregulation of multiple mitogen-activated protein kinases in eukaryotic cells |
| Q84789661 | c-Jun-NH2 terminal kinase (JNK)-mediates AP-1 activation by thioredoxin: phosphorylation of cJun, JunB, and Fra-1 |
| Q39450413 | c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents |
| Q36993715 | p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes |
| Q24554203 | p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps |
| Q28115373 | p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expression |
| Q30168962 | v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation |
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