Protein kinase C δ (PKCδ)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia

scientific article published on 5 March 2012

Protein kinase C δ (PKCδ)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.308841
P932PMC publication ID3340148
P698PubMed publication ID22393041

P2093author name stringHyun Kyu Kang
In Duk Jung
Ji Chang You
Kwang Hee Son
Kyung Tae Noh
Sun Ae Hwang
Won Suk Lee
Yeong-Min Park
P2860cites workToll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.Q42431545
GSK-3β-induced ASK1 stabilization is crucial in LPS-induced endotoxin shock.Q44285737
The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failureQ47957928
Protective and pathological roles of nitric oxide in endotoxin shockQ50181902
Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003.Q53238938
PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cellsQ64378078
Endogenous IL-10 protects mice from death during septic peritonitisQ71829356
Microvascular responses to sepsis: clinical significanceQ74210483
IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defenseQ77787573
What is the role of interleukin 10 in polymicrobial sepsis: anti-inflammatory agent or immunosuppressant?Q78153610
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of careQ27860820
Interleukin-10Q28263225
The MAPK signaling cascadeQ28292599
The epidemiology of sepsis in the United States from 1979 through 2000Q29547760
Toll-like receptors: critical proteins linking innate and acquired immunityQ29615190
Toll-like receptors and innate immunityQ29615458
The renaissance of GSK3Q29616725
The glamour and gloom of glycogen synthase kinase-3Q29620533
Mitogen-activated protein kinases: specific messages from ubiquitous messengersQ30303652
Judging a protein by more than its name: GSK-3.Q34093128
Interleukin-10 controls the onset of irreversible septic shockQ34128782
Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinaseQ34478838
Drosophila innate immunity: an evolutionary perspectiveQ34507042
Molecular basis of endothelial dysfunction in sepsisQ35548735
Cytokine Cascade in SepsisQ35585026
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functionsQ36360691
Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemiaQ36361322
Interleukin 10 protects mice from lethal endotoxemiaQ36361558
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysisQ36392617
The role of glycogen synthase kinase 3 in regulating IFN-β-mediated IL-10 productionQ36712311
Microvascular perfusion is impaired in a rat model of normotensive sepsisQ36727054
The immunology of sepsis.Q37045773
Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in ratsQ37370193
Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsisQ37480055
Endogenous IL-10 regulates sepsis-induced thymic apoptosis and improves survival in septic IL-10 null miceQ37618990
Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1).Q40671035
Regulation and function of the JNK subgroup of MAP kinasesQ41659032
Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shockQ41662628
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectendotoxemiaQ5832599
lipopolysaccharideQ421804
P1104number of pages8
P304page(s)14226-14233
P577publication date2012-03-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleProtein kinase C δ (PKCδ)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia
P478volume287