Microvascular perfusion is impaired in a rat model of normotensive sepsis

scientific article published on November 1994

Microvascular perfusion is impaired in a rat model of normotensive sepsis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI117562
P932PMC publication ID294647
P698PubMed publication ID7962554
P5875ResearchGate publication ID15235794

P2093author name stringMartin C
Lam C
Tyml K
Sibbald W
P2860cites workDefinitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care MedicineQ22306067
Oxygen consumption in sepsis and septic shockQ28315998
Measurement of oxygen diffusion distance in tumor cubes using a fluorescent hypoxia probeQ33278258
Simultaneous assessment of red cell perfusion in skeletal muscle by laser Doppler flowmetry and video microscopy.Q36490235
Gram-negative sepsis. Background, clinical features, and interventionQ37296912
Laboratory models of sepsis and septic shockQ37945490
Oxygen delivery and uptake by peripheral tissues: physiology and pathophysiologyQ38617901
Theory of oxygen transport to tissueQ38688402
Heterogeneity of microvascular flow in rat skeletal muscle is reduced by contraction and by hemodilutionQ41182911
Role of neutrophils in endotoxin-mediated microvascular injury in hamstersQ41853150
Role of the microcirculation to skeletal muscle during shockQ43438426
Endotoxin-induced increase in leukocyte adherence and macromolecular permeability of postcapillary venulesQ43551806
Reduced microvascular adrenergic receptor activity due to opioids in endotoxin shockQ43591125
Regulation of perfused capillary density in canine intestinal mucosa during endotoxemiaQ43615598
Reduced RBC versus plasma microvascular flow due to endotoxinQ43764116
In vivo effects of Escherichia coli endotoxemia on diaphragmatic microcirculation in ratsQ43940941
Peripheral vascular tone in sepsisQ44360268
The rate of oxygen release and its effect on capillary O2 tension: a mathematical analysisQ44649129
Elevation of cardiac output and oxygen delivery improves outcome in septic shockQ46090707
Polymorphonuclear neutrophil contribution to induced tolerance to bacterial lipopolysaccharideQ46706465
Differential impairment of vascular reactivity of small pulmonary and systemic arteries in hyperdynamic sepsis.Q54237003
Sepsis-induced diastolic dysfunction in chronic canine peritonitis.Q54328896
Role of muscle microvasculature during hyperdynamic and hypodynamic phases of endotoxin shock in decerebrate rats.Q54387732
EDRF as a possible mediator of sepsis-induced arteriolar dilation in skeletal muscleQ54682504
Lung fluid dynamics and supply dependency of oxygen uptake during experimental endotoxic shock and volume resuscitation.Q54694750
Critical O2 delivery to skeletal muscle at high and low PO2 in endotoxemic dogs.Q54729221
Endotoxin effects on capillary transit times of RBC and plasma as measured by indicator dilutionQ67236998
A new preparation of rat extensor digitorum longus muscle for intravital investigation of the microcirculationQ67834650
Distribution of red blood cell velocity in capillary network, and endothelial ultrastructure, in aged rat skeletal muscleQ68228330
Hyperdynamic sepsis modifies a PEEP-mediated redistribution in organ blood flowsQ68510465
Skeletal muscle microcirculation: the effects of limited blood supply and treatment with torbafyllineQ68664471
Histologic and ultrastructural changes in nonpulmonary organs during early hyperdynamic sepsisQ68744273
Hepatic parenchymal oxygen tension following injury and sepsisQ68746601
Red cell perfusion in skeletal muscle at rest and after mild and severe contractionsQ68816242
Skeletal microcirculatory responses to hyperdynamic Escherichia coli sepsis in unanesthetized ratsQ68926926
Erythrocyte deformability in canine septic shock and the efficacy of pentoxifylline and a leukotriene antagonistQ68953556
Microvascular responses to E. coli endotoxin with altered adrenergic activityQ70338081
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmicrovesselQ6840468
sepsisQ183134
P304page(s)2077-2083
P577publication date1994-11-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleMicrovascular perfusion is impaired in a rat model of normotensive sepsis
P478volume94

Reverse relations

cites work (P2860)
Q33545585Acidosis and tissue hypoxia in the critically ill: how to measure it and what does it mean
Q46960326Acute peritonitis leads to early remote microvascular dysfunction
Q38016896Alterations of the Erythrocyte Membrane during Sepsis
Q31958833Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat.
Q44098585Ascorbate reduces mouse platelet aggregation and surface P-selectin expression in an ex vivo model of sepsis
Q33750678Assessments of skin and tongue microcirculation reveals major changes in porcine sepsis
Q24794238Bench-to-bedside review: endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?
Q24795984Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide
Q24800640Bench-to-bedside review: sepsis is a disease of the microcirculation
Q102075457Comparing effects of intraoperative fluid and vasopressor infusion on intestinal microcirculation
Q36226452Contribution of the platelet activating factor signaling pathway to cerebral microcirculatory dysfunction during experimental sepsis by ExoU producing Pseudomonas aeruginosa.
Q51694307Critical oxygen delivery in conscious septic rats under stagnant or anemic hypoxia.
Q37825577Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis
Q58803471Differential Mechanisms of Septic Human Pulmonary Microvascular Endothelial Cell Barrier Dysfunction Depending on the Presence of Neutrophils
Q34140360Disassociation of muscle insulin signaling and insulin-stimulated glucose uptake during endotoxemia
Q30493116Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis
Q51956313Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: role of heterogeneous capillary spacing and blood flow.
Q41848476Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic rate during longterm endotoxin-induced shock in pigs
Q44582181Effect of nitric oxide on capillary hemodynamics and cell injury in the pancreas during Pseudomonas pneumonia-induced sepsis
Q30952847Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: interpreting capillary oxygen transport data using a mathematical model
Q33863326Effects of dobutamine on intestinal microvascular blood flow heterogeneity and O2 extraction during septic shock
Q43917690Effects of modest anemia on systemic and coronary circulation of septic sheep
Q41831082Electrical communication in branching arterial networks.
Q38845321Endothelial and Microcirculatory Function and Dysfunction in Sepsis.
Q22000728Enoxaparin sodium prevents intestinal microcirculatory dysfunction in endotoxemic rats.
Q43610555Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis
Q36392457Erythropoietin improves skeletal muscle microcirculation and tissue bioenergetics in a mouse sepsis model
Q36578016Hemodynamic management of septic shock.
Q33730266Hyperaemia
Q37391348Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis
Q47729619Impact of Incremental Perfusion Loss on Oxygen Transport in a Capillary Network Mathematical Model
Q34618265Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries
Q40215829Impairments in microvascular reactivity are related to organ failure in human sepsis
Q31142710In vivo study of experimental pneumococcal meningitis using magnetic resonance imaging
Q44026978Increasing P(50) does not improve DO(2CRIT) or systemic VO(2) in severe anemia
Q46549649Inducible nitric oxide synthase inhibition improves intestinal microcirculatory oxygenation and CO2 balance during endotoxemia in pigs
Q42457026Influence of sepsis on the plasma elimination pharmacokinetics of diaspirin crosslinked hemoglobin in rats
Q37637820Inhibition of Murine Pulmonary Microvascular Endothelial Cell Apoptosis Promotes Recovery of Barrier Function under Septic Conditions.
Q73114477Intermittent flow increases endotoxin-induced adhesion of human erythrocytes to vascular endothelial cells
Q43726997Is there a place for prostacyclin in the treatment of septic shock?
Q43713937Lipopolysaccharide reduces intercellular coupling in vitro and arteriolar conducted response in vivo
Q44919350Lung albumin accumulation is spatially heterogeneous but not correlated with regional pulmonary perfusion
Q35964998Mapping 3-D functional capillary geometry in rat skeletal muscle in vivo
Q89338772Mechanisms of Hemolysis During Sepsis
Q37030681Microcirculation and oxidative stress
Q61450709Microcirculation dysfunction in endotoxic shock rabbits is associated with impaired S-nitrosohemoglobin-mediated nitric oxide release from red blood cells: a preliminary study
Q36259598Microcirculatory alterations in ischemia-reperfusion injury and sepsis: effects of activated protein C and thrombin inhibition
Q26798312Microcirculatory dysfunction and resuscitation: why, when, and how
Q27008088Microcirculatory dysfunction and tissue oxygenation in critical illness
Q38815302Microcirculatory dysfunction in sepsis: pathophysiology, clinical monitoring, and potential therapies
Q59330096Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial
Q27694575Microparticles: markers and mediators of sepsis-induced microvascular dysfunction, immunosuppression, and AKI
Q44045816Microvascular blood flow is altered in patients with sepsis
Q45283334Microvascular dysfunction and skeletal muscle oxygenation assessed by phase-modulation near-infrared spectroscopy in patients with septic shock
Q36259605Microvascular dysfunction as a cause of organ dysfunction in severe sepsis
Q77610240Microvascular oxygen pressure in the pig intestine during haemorrhagic shock and resuscitation
Q74210483Microvascular responses to sepsis: clinical significance
Q36259588Microvascular resuscitation as a therapeutic goal in severe sepsis
Q33688251Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis
Q33279277Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia
Q58863636Nitric Oxide, Oxidative Stress, Immune Response and Critical Care
Q43990890Nitric oxide produced via neuronal NOS may impair vasodilatation in septic rat skeletal muscle
Q38995613No relationship between red blood cell distribution width and microcirculatory alterations in septic patients.
Q43745453Normovolemic hemodilution improves oxygen extraction capabilities in endotoxic shock.
Q44333801Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters.
Q43794530Organ dysfunction during sepsis
Q34631065Physiopathology of shock
Q35922200Protein kinase C δ (PKCδ)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia
Q35091785Pulmonary microvascular albumin leak is associated with endothelial cell death in murine sepsis-induced lung injury in vivo
Q43918325Red blood cell aggregation in experimental sepsis
Q35152415Red blood cell rheology in sepsis.
Q30489561Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials
Q92523427Resuscitation incoherence and dynamic circulation-perfusion coupling in circulatory shock
Q37824131Role of connexins in microvascular dysfunction during inflammation
Q40996335Role of pulmonary microvascular endothelial cell apoptosis in murine sepsis-induced lung injury in vivo
Q27339785Sepsis impairs microvascular autoregulation and delays capillary response within hypoxic capillaries.
Q36948888Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism
Q74598620Septic shock
Q38468012Shock - A reappraisal: The holistic approach
Q24801198Shockingly complex: the difficult road to introducing new ideas to critical care
Q46604570Short-term hyperglycemia increases endothelial glycocalyx permeability and acutely decreases lineal density of capillaries with flowing red blood cells
Q53253169Side-by-Side Alterations in Glycocalyx Thickness and Perfused Microvascular Density During Acute Microcirculatory Alterations in Cardiac Surgery.
Q30423744Skeletal muscle capillary function: contemporary observations and novel hypotheses
Q46950160Sublingual capnometry tracks microcirculatory changes in septic patients
Q50464421Systemic microvascular shunting through hyperdynamic capillaries after acute physiological disturbances following cardiopulmonary bypass.
Q52861095Tetrahydrobiopterin improves microcirculation in experimental sepsis.
Q41660779The Effect of Sepsis on the Erythrocyte
Q34060215The dynamic regulation of microcirculatory conduit function: features relevant to transfusion medicine
Q48024707The effect of Escherichia coli endotoxin infusion on the ventilatory response to hypoxia in unanesthetized newborn piglets
Q48054953The endothelial glycocalyx promotes homogenous blood flow distribution within the microvasculature.
Q37587025The microcirculation as a diagnostic and therapeutic target in sepsis
Q36259593The microcirculation as a functional system
Q33282435The microcirculation in critically-ill patients
Q24633735The microcirculation is the motor of sepsis
Q40881719The microcirculatory failure could not weaken the increase of systematic oxygen extraction rate in septic shock: An observational study in canine models
Q64126793The prognostic value of muscle StO2 in septic patients
Q36009630Tissue capnometry: does the answer lie under the tongue?
Q37118378What is the efficiency of ATP signaling from erythrocytes to regulate distribution of O(2) supply within the microvasculature?
Q80697200[Microcirculation of intensive care patients. From the physiology to the bedside]

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