Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium

scientific article published on July 1, 1983

Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1983PNAS...80.4276C
P356DOI10.1073/PNAS.80.14.4276
P953full work available at URLhttps://www.pnas.org/content/pnas/80/14/4276.full.pdf
https://europepmc.org/articles/PMC384020
https://europepmc.org/articles/PMC384020?pdf=render
https://pnas.org/doi/pdf/10.1073/pnas.80.14.4276
P932PMC publication ID384020
P698PubMed publication ID6308612
P5875ResearchGate publication ID16886897

P2093author name stringJ. Codina
J. Hildebrandt
L. Birnbaumer
R. Iyengar
C. R. Manclark
R. D. Sekura
P2860cites workProtein measurement with the Folin phenol reagentQ20900776
Complete Amino-Acid Sequence of Actin of Rabbit Skeletal MuscleQ24562953
Purification of the regulatory component of adenylate cyclaseQ24609191
Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotidesQ24629881
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
The regulatory component of adenylate cyclase. Purification and propertiesQ34252831
The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte proteinQ34252911
The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand bindingQ34253708
Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase systemQ34708038
Relationship between the beta-adrenergic receptor and adenylate cyclaseQ34991997
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane proteinQ36295605
Properties of the separated catalytic and regulatory units of brain adenylate cyclaseQ36413502
3,3′,5-Triiodothyronine Administration In Vivo Modulates the Hormone-sensitive Adenylate Cyclase System of Rat HepatocytesQ37007778
Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase systemQ37588093
ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclaseQ37589612
The enzymatic preparation of [alpha-32P]ATP, [alpha-32P]GTP, [32P]cAMP, and [32P]cGMP, and their use in the assay of adenylate and guanylate cyclases and cyclic nucleotide phosphodiesterasesQ39254691
Selection of a Variant Lymphoma Cell Deficient in Adenylate CyclaseQ39919612
Bimodal regulation of adenylate cyclaseQ40086581
Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclaseQ40178723
Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptorsQ40217302
Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cellsQ41533814
Hormone-stimulated desensitization of hormone-dependent adenylyl cyclase. Dual action of luteninizing hormone on pig graafian follicle membranesQ42443756
Differentiation-dependent expression of catecholamine-stimulated adenylate cyclase. Roles of the beta-receptor and G/F protein in differentiating 3T3-L1 adipocytesQ42826259
Resolution of some components of adenylate cyclase necessary for catalytic activity.Q43782034
A Reinvestigation of the Molecular Weight of Glycogen PhosphorylaseQ47405219
A highly sensitive adenylate cyclase assayQ47871494
ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.Q55489833
Comparative hydrodynamic study of carbonic anhydrases A and B from bovine erythrocytesQ67255432
GTP-binding proteins in membranes and the control of adenylate cyclase activityQ67675972
Studies on Soybean Trypsin Inhibitors. 1. Fragmentation of Soybean Trypsin Inhibitor (Kunitz) by Limited Proteolysis and by Chemical CleavageQ69578582
Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclaseQ70168321
Regulation of adenylate cyclase of human platelet membranes by forskolinQ70239834
Hysteretic activation of adenylyl cyclases. II. Mg ion regulation of the activation of the regulatory component as analyzed by reconstitutionQ70945668
A regulatory component of adenylate cyclase from human erythrocyte membranesQ71160161
Divalent cation-induced desensitization of glucagon-stimulable adenylyl cyclase in rat liver plasma membrane. GTP-dependent stimulation by glucagonQ71524090
Examination of the dissociation of multichain proteins in guanidine hydrochloride by membrane osmometryQ72134616
Comparison of the Amino Acid Sequence of Bovine α-Lactalbumin and Hens Egg White LysozymeQ72252717
Inhibition of adenylate cyclase by hormones and neurotransmittersQ72496733
Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cellsQ72629440
Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activityQ72902864
Receptor-mediated stimulation and inhibition of adenylate cyclases: the fat cell as a model systemQ72907676
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectmagnesiumQ660
guanineQ169313
P304page(s)4276-4280
P577publication date1983-07-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium
P478volume80

Reverse relations

cites work (P2860)
Q33919591A Go-like protein in Drosophila melanogaster and its expression in memory mutants
Q70212798A light‐stimulated increase of cyclic GMP in squid photoreceptors
Q45146239Adenosine inhibits histamine-induced phosphoinositide hydrolysis mediated via pertussis toxin-sensitive G protein in human astrocytoma cells
Q41433400Adenylate cyclase from bovine brain cortex: purification and characterization of the catalytic unit
Q48643474Altered activity of the inhibitory guanyl nucleotide-binding component (Ni) induced by pertussis toxin. Uncoupling of Ni from receptor with continued coupling of Ni to the catalytic unit
Q33586850Antibody specific to the alpha subunit of the guanine nucleotide-binding regulatory protein Go: developmental appearance and immunocytochemical localization in brain
Q39503017Bacterial toxins and the role of ADP-ribosylation
Q28119200Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical
Q37563068Binding of [3H]forskolin to rat brain membranes
Q40094669Biochemical Characteristics and Regulation of Brain ?2-Adrenoceptors
Q42053081Calcium channel currents and their inhibition by (-)-baclofen in rat sensory neurones: modulation by guanine nucleotides
Q37687434Catalytic unit of adenlyate cyclase: purification and identification by affinity crosslinking
Q44656113Cholinergic inhibition of cAMP accumulation in Sertoli cells cultured from immature hamsters
Q42506781Comparative effects of cholera and Bordetella pertussis toxins on cyclic AMP and GTP levels and on lipolysis in rat adipocytes incubated in vitro
Q68971784Cyclic adenosine monophosphate, calcium, acetylcholine and the current induced by adenosine in the Xenopus oocyte
Q40852835Decreased adenylyl cyclase protein and function in airway smooth muscle by chronic carbachol pretreatment
Q70219005Differential effect of pertussis toxin on the affinity state for agonists of renal alpha 1- and alpha 2- adrenoceptors
Q44346836Differential regulation of two molecular forms of a mu-opioid receptor type by sodium ions, manganese ions and by guanyl-5'-yl imidodiphosphate
Q38204206Direct G-protein regulation of Ca2+ channels
Q33940104Does the guanine nucleotide regulatory protein Ni mediate progesterone inhibition of Xenopus oocyte adenylate cyclase?
Q70218338Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists
Q38588139From GTP and G proteins to TRPC channels: a personal account
Q52251271G protein-adrenergic interactions in the heart.
Q37581292G proteins and the mechanism of action of hormones, neurotransmitters, and autocrine and paracrine regulatory factors
Q54106057G proteins mediate suppression of Ca2+-activated K current by acetylcholine in smooth muscle cells.
Q48657626GTPase activity associates with the inhibitory GTP-binding regulatory component of adenylate cyclase purified from rat brain
Q39324493Guanine nucleotide binding proteins and signal transduction
Q41137367Heart Rate Regulation by G Proteins Acting on the Cardiac Pacemaker Channel
Q67879377Heterogeneity of Guanine Nucleotide Binding Proteins in Human Red Blood Cell Membranes
Q89982570Heterotrimeric Gq proteins as therapeutic targets?
Q53878092Hormonal regulation of pituitary GH3 cell K+ channels by Gk is mediated by its alpha-subunit.
Q42247019Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine
Q34557266Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart
Q28509489Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains
Q41814207Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes
Q36273860Interactions of maitotoxin with voltage-sensitive calcium channels in cultured neuronal cells
Q42202952Islet-activating protein blocks glucagon desensitization in intact hepatocytes
Q42073282Magnesium ion exerts a central role in the regulation of inhibitory adenosine receptors
Q72575392Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site
Q39462024Mechanisms of bacterial pathogenicity that involve production of calmodulin-sensitive adenylate cyclases
Q39104035Membrane association of soluble protein activators of rat liver adenylate cyclase. Evidence for distinctness from the guanine nucleotide-binding stimulating protein (Ns).
Q40485151Membrane-delimited cell signaling complexes: Direct ion channel regulation by G Proteins
Q43728861Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor
Q33721127Molecular mechanisms of go signaling
Q37041543Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections
Q69721025NADP efficiently inhibits endogenous but not pertussis toxin-catalyzed covalent modification of membrane proteins incubated with NAD
Q70202047Ns and Ni, the stimulatory and inhibitory regulatory components of adenylyl cyclases. Purification of the human erythrocyte proteins without the use of activating regulatory ligands
Q37354062On the origins and present state of the art of G protein research
Q70497842Oocyte adenylyl cyclase contains Ni, yet the guanine nucleotide-dependent inhibition by progesterone is not sensitive to pertussis toxin
Q42811237Pertussis toxin alters the growth characteristics of Swiss 3T3 cells
Q45215679Pertussis toxin blocks melatonin-induced pigment aggregation in Xenopus dermal melanophores
Q42848179Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumour cells
Q36350292Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes
Q37685522Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line
Q69868321Pertussis toxin selectively abolishes hormone induced lowering of cytosolic calcium in GH3 cells
Q42137007Pertussis toxin substrate is a guanosine 5'-[beta-thio]diphosphate-, N-ethylmaleimide-, Mg2+- and temperature-sensitive GTP-binding protein
Q50926116Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase
Q41275137Phorbol ester-induced inhibition of the beta-adrenergic system in pulmonary endothelium: role of a pertussis toxin-sensitive protein
Q37675950Purification and characterization of the mu opiate receptor from rat brain using affinity chromatography
Q48600692Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase
Q55062491Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase
Q44167739Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein
Q45800134Re-evaluation of chicken CXCR1 determines the true gene structure: CXCLi1 (K60) and CXCLi2 (CAF/interleukin-8) are ligands for this receptor
Q72411542Receptor to Effector Coupling in the Receptor-Dependent Adenylate Cyclase System
Q43724552Regulation of Paramecium primaurelia glycosylphosphatidyl-inositol biosynthesis via dolichol phosphate mannose synthesis
Q36563398Regulation of type I adenylyl cyclase by calmodulin kinase IV in vivo
Q36954421Roles of protein kinase C and G proteins in activation of murine resting B lymphocytes by endotoxin-associated protein
Q41198852Signal transduction by G proteins: 1994 edition
Q37807994Signal transductionviaG protein coupled receptors: a personal outlook
Q33429986Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium
Q48494340Solubilization and characterization of rat brain alpha 2-adrenergic receptor
Q48371159Subcellular distributions of calcium/calmodulin-stimulated and guanine nucleotide-regulated adenylate cyclase activities in the cerebral cortex
Q48445568Subunit interactions of the Go protein
Q91827049Targeting G protein-coupled receptor signalling by blocking G proteins
Q42175826The Aplnr GPCR regulates myocardial progenitor development via a novel cell-non-autonomous, Gα(i/o) protein-independent pathway
Q44508440The GTP-binding protein, Go, regulates neuronal calcium channels
Q42853134The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes
Q41138602The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning
Q36250050The diphtheria bacillus and its toxin: a model system
Q30443268The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding
Q34396829The human genome encodes at least three non-allellic G proteins with alpha i-type subunits
Q27325503The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis
Q42848486The relationship between pertussis-toxin-induced ADP-ribosylation of a plasma-membrane protein and reversal of muscarinic inhibition of prolactin secretion in GH3 cells
Q34509487The superfamily of heptahelical receptors
Q37394340Treatment of human platelets with trypsin, thrombin, or collagen inhibits the pertussis toxin-induced ADP-ribosylation of a 41-kDa protein
Q64941855Updated Protocols and Comments on the Purification without Use of Activating Ligands of the Coupling Proteins Nsand Niof the Hormone Sensitive Adenylyl Cyclase

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