Core structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation

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Core structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation is …
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scholarly articleQ13442814

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P356DOI10.1016/J.STR.2008.08.013
P932PMC publication ID2743916
P698PubMed publication ID19000817
P5875ResearchGate publication ID23465320

P2093author name stringGrant A Hartzog
Min Guo
Maikun Teng
Yongxiang Gao
Liwen Niu
Fei Xu
Jena Yamada
Thea Egelhofer
P2860cites workDSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologsQ24328838
Transcription elongation factor hSPT5 stimulates mRNA cappingQ24601724
The integrated microbial genomes (IMG) systemQ25257667
Improved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activitiesQ27639536
A spring-loaded state of NusG in its functional cycle is suggested by X-ray crystallography and supported by site-directed mutantsQ27640575
Structural Basis for Converting a General Transcription Factor into an Operon-Specific Virulence RegulatorQ27644445
Structural basis for transcription elongation by bacterial RNA polymeraseQ27646092
Enhanced protein thermostability from designed mutations that interact with alpha-helix dipolesQ27728543
Clustal W and Clustal X version 2.0Q27860517
Principles of protein-protein interactionsQ27860855
The Jalview Java alignment editorQ27861026
The CCP4 suite: programs for protein crystallographyQ27861090
Mapping the protein universeQ27861112
Automated MAD and MIR structure solutionQ27861114
Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteinsQ27930157
RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processingQ27934335
Npl3 is an antagonist of mRNA 3' end formation by RNA polymerase II.Q27935622
Faithful chromosome transmission requires Spt4p, a putative regulator of chromatin structure in Saccharomyces cerevisiaeQ27936106
Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiaeQ27937704
NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongationQ28141291
Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complexQ28185959
Controlling the elongation phase of transcription with P-TEFbQ28255518
Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerasesQ29617053
WWW-query: an on-line retrieval system for biological sequence banksQ29617307
The impact of comparative genomics on our understanding of evolutionQ30885287
SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiaeQ33959909
Rho-dependent terminators and transcription terminationQ33999162
The genetic core of the universal ancestorQ34181411
Transcription elongation complex: structure and functionQ34204960
Novel domains and orthologues of eukaryotic transcription elongation factors.Q34376707
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factorsQ34419716
Breaking barriers to transcription elongationQ34561019
Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation.Q34654219
High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongationQ35205005
NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in DrosophilaQ35965503
Sigma and RNA polymerase: an on-again, off-again relationship?Q36312263
Domain swapping is a consequence of minimal frustrationQ37535259
A quaternary transcription termination complex. Reciprocal stabilization by Rho factor and NusG proteinQ38302602
In Vivo Evidence that Defects in the Transcriptional Elongation Factors RPB2, TFIIS, and SPT5 Enhance Upstream Poly(A) Site UtilizationQ39940501
Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogasterQ40445025
Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexesQ41871737
Interactions between fission yeast mRNA capping enzymes and elongation factor Spt5.Q43917514
Exploring functional relationships between components of the gene expression machinery.Q46675062
Structural and sequence comparisons arising from the solution structure of the transcription elongation factor NusG from Thermus thermophilusQ47430906
Combinatorial effects of NusA and NusG on transcription elongation and Rho-dependent termination in Escherichia coliQ47625631
Molecular and genetic characterization of SPT4, a gene important for transcription initiation in Saccharomyces cerevisiaeQ48129869
The transcriptional regulator RfaH stimulates RNA chain synthesis after recruitment to elongation complexes by the exposed nontemplate DNA strand.Q54545830
SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeatQ70234995
P433issue11
P921main subjectTranscription elongation factor SPT5 YML010WQ27553017
Transcription elongation factor SPT4 YGR063CQ27553019
P304page(s)1649-1658
P577publication date2008-11-01
P1433published inStructureQ15709970
P1476titleCore structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation
P478volume16

Reverse relations

cites work (P2860)
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