Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment.

scientific article published on 02 May 2013

Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/TOXSCI/KFT105
P932PMC publication ID3842105
P698PubMed publication ID23640862
P5875ResearchGate publication ID236614888

P50authorTammy DugasQ73521649
P2093author name stringValeria Y Hebert
Mitzi Glover
Stephen Y Xue
Corie N Robinson
Danicia M Hayes
P2860cites workNix, a receptor protein for mitophagy in mammalsQ24301612
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cellsQ43258050
A comparison of the steady-state pharmacokinetics and safety of abacavir, lamivudine, and zidovudine taken as a triple combination tablet and as abacavir plus a lamivudine-zidovudine double combination tablet by HIV-1-infected adultsQ43580186
NADH: sensor of blood flow need in brain, muscle, and other tissues.Q43626588
The mitochondrial permeability transition initiates autophagy in rat hepatocytes.Q43711895
Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytesQ43798796
Nucleoside reverse transcriptase inhibitors (NRTIs)-induced expression profile of mitochondria-related genes in the mouse liverQ44005668
Antiretrovirals induce direct endothelial dysfunction in vivo.Q44083807
Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxideQ44185615
Cardiovascular disease risk factors in HIV patients--association with antiretroviral therapy. Results from the DAD studyQ44486385
Effects of HIV drug combinations on endothelin-1 and vascular cell proliferation.Q45061915
Comparison of the risks of atherosclerotic events versus death from other causes associated with antiretroviral useQ56830806
HIV antiretroviral drug combination induces endothelial mitochondrial dysfunction and reactive oxygen species production, but not apoptosisQ64377031
Coronary heart disease in HIV-infected individualsQ73687564
Cardiomyopathy, nucleoside reverse transcriptase inhibitors and mitochondria are linked through AIDS and its therapyQ81110657
Selective degradation of mitochondria by mitophagyQ24658163
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1Q28131760
Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of HypertensionQ28301973
The roles of HIV-1 proteins and antiretroviral drug therapy in HIV-1-associated endothelial dysfunctionQ28386344
Mitochondria, oxidants, and agingQ29547594
Antiretrovirals induce endothelial dysfunction via an oxidant-dependent pathway and promote neointimal hyperplasiaQ30430542
Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivationQ30498226
Dipyridamole enhances ischaemia-induced arteriogenesis through an endocrine nitrite/nitric oxide-dependent pathwayQ33522876
Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytesQ33556360
Autophagy in health and disease. 5. Mitophagy as a way of lifeQ34085696
Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factorsQ34121511
Signaling pathways in mitochondrial dysfunction and agingQ34170340
Mitochondrial disease: a pulmonary and critical-care medicine perspectiveQ34335818
Autophagy: assays and artifactsQ34341096
Pharmacokinetics of tenofovir disoproxil fumarate and ritonavir-boosted saquinavir mesylate administered alone or in combination at steady stateQ34510726
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and agingQ34556311
Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS.Q35564144
Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondriaQ35601295
Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogsQ35879021
Direct, DNA pol-gamma-independent effects of nucleoside reverse transcriptase inhibitors on mitochondrial bioenergeticsQ35911365
Mitochondrial dysfunction as an initiating event in atherogenesis: a plausible hypothesisQ36017632
Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylationQ36535244
Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylationQ36870637
Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunctionQ37270571
Oxidative stress, endothelial dysfunction and atherosclerosis.Q37597217
Autophagy and the degradation of mitochondriaQ37677293
Autophagosome formation and molecular mechanism of autophagy.Q37780202
Molecular mechanisms of superoxide production by the mitochondrial respiratory chain.Q38021399
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.Q38296946
Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitorsQ38568978
Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I.Q39853002
Mitochondrial toxicity of antiviral drugsQ40429889
Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potentialQ40541135
Nuclear control of respiratory chain expression in mammalian cellsQ41547358
Endothelial cell monolayers as a tool for studying microvascular pathophysiologyQ41685270
Determination of the blood lactate:pyruvate ratio as a noninvasive test for the diagnosis of zidovudine myopathy.Q42285194
Allosteric nucleotide-binding site in the mitochondrial NADH:ubiquinone oxidoreductase (respiratory complex I).Q42823476
P4510describes a project that usesImageJQ1659584
P433issue2
P921main subjectendotheliumQ111140
cytotoxicityQ246181
ubidecarenoneQ321285
P304page(s)323-334
P577publication date2013-05-02
P1433published inToxicological SciencesQ2446966
P1476titleNucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment
P478volume134

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cites work (P2860)
Q44797235Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity.
Q51538858Drug-Induced Mitochondrial Toxicity.
Q37165704Effect of rosuvastatin on plasma coenzyme Q10 in HIV-infected individuals on antiretroviral therapy
Q34759994Increased coronary vessel wall thickness in HIV-infected young adults
Q39565701Mitochondrial compromise in 3-year old patas monkeys exposed in utero to human-equivalent antiretroviral therapies
Q46130631Nucleoside/nucleotide reverse transcriptase inhibitors attenuate angiogenesis and lymphangiogenesis by impairing receptor tyrosine kinases signalling in endothelial cells
Q47574017Nucleotide Reverse Transcriptase Inhibitors: A Thorough Review, Present Status and Future Perspective as HIV Therapeutics
Q35556516Overexpression of mitochondrial antioxidant manganese superoxide dismutase (MnSOD) provides protection against AZT- or 3TC-induced endothelial dysfunction.