Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence

scientific article published on 08 July 2009

Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEUROPHARM.2009.06.044
P932PMC publication ID2745083
P698PubMed publication ID19591852
P5875ResearchGate publication ID26660806

P2093author name stringDavid Alexoff
Bruce M Cohen
Jacob M Hooker
Cécile Béguin
Youwen Xu
Colleen Shea
Thomas A Munro
P2860cites workSalvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonistQ24535736
2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin AQ24642017
Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethersQ24651427
Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonistQ24656126
Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responsesQ24683322
Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in ratsQ28273954
Possible pharmacotherapy of the opioid kappa receptor agonist for drug dependenceQ28293155
Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in ratsQ28307145
Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawalQ28379331
Salvinorin A analogs as probes in opioid pharmacologyQ30439719
Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptorsQ33984723
Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.Q34165326
Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in ratsQ34185186
A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A.Q34350014
Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in ratsQ34459404
Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18).Q34538561
Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in ratsQ34682154
8-epi-Salvinorin B: crystal structure and affinity at the kappa opioid receptorQ35652097
Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans.Q36766665
Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatumQ36979184
Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluidQ37192749
Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogenQ37286215
Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuseQ37355904
Pharmacological mechanisms of opioid analgesics.Q39496101
Sensitization to the Behavioral Effects of Cocaine: Modulation by Dynorphin and κ-Opioid Receptor AgonistsQ41527783
Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouseQ44350970
In vitro stability and metabolism of salvinorin A in rat plasmaQ46091354
P433issue4
P304page(s)386-391
P577publication date2009-07-08
P1433published inNeuropharmacologyQ15332439
P1476titleSalvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence
P478volume57

Reverse relations

cites work (P2860)
Q35637848A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.
Q88257901A review of salvinorin analogs and their kappa-opioid receptor activity
Q46178251Analysis of Salvinorin A in urine using microextraction in packed syringe and GC-MS/MS.
Q58611571Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice
Q38902043Clerodane diterpenes: sources, structures, and biological activities
Q64111902Cutting-Edge Search for Safer Opioid Pain Relief: Retrospective Review of Salvinorin A and Its Analogs
Q30447153Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the κ opioid agonist Salvinorin A in humans
Q36894509Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET.
Q37725698Kappa opioids and the modulation of pain
Q37451366LC-MS/MS quantification of salvinorin A from biological fluids
Q30467220Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A
Q34851195Opioid receptor probes derived from cycloaddition of the hallucinogen natural product salvinorin A.
Q57888900Salvia divinorum: toxicological aspects and analysis in human biological specimens
Q34820974Salvinorin A decreases mortality and improves neurological outcome in a neonatal mouse hypoxia model
Q42073472Salvinorin B methoxymethyl ether
Q36775253Selective Manipulation of Neural Circuits
Q37495486Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity.
Q47878237The C-2 derivatives of salvinorin A, ethoxymethyl ether Sal B and β-tetrahydropyran Sal B, have anti-cocaine properties with minimal side effects.
Q33835281The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects

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