A phase I and pharmacokinetics study of intravenous calcitriol in combination with oral dexamethasone and gefitinib in patients with advanced solid tumors

scientific article published on 26 April 2009

A phase I and pharmacokinetics study of intravenous calcitriol in combination with oral dexamethasone and gefitinib in patients with advanced solid tumors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00280-009-1000-2
P932PMC publication ID2746253
P698PubMed publication ID19396601
P5875ResearchGate publication ID24362219

P2093author name stringCandace S Johnson
Donald L Trump
Marwan G Fakih
Josephia R Muindi
Kristie L Engler
Renee Christy
P2860cites workNew guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of CanadaQ27860904
A Phase I trial of calcitriol (1,25-dihydroxycholecalciferol) in patients with advanced malignancyQ28368222
Activation of extracellular signal-regulated kinases (ERKs) defines the first phase of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cellsQ31910647
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1alpha,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma modelQ36982956
Intestinal calcium absorption in exogenous hypercortisonism. Role of 25-hydroxyvitamin D and corticosteroid doseQ37045709
Differential antiproliferative effects of calcitriol on tumor-derived and matrigel-derived endothelial cellsQ38310048
Growth regulation of human colon cancer cells by epidermal growth factor and 1,25-dihydroxyvitamin D3 is mediated by mutual modulation of receptor expressionQ40968454
Transforming growth factor-beta potentiates vitamin D3-induced terminal monocytic differentiation of human leukemic cell linesQ41565934
Differentiating and antitumor activities of 1 alpha,25-dihydroxyvitamin D3 in vitro and 1 alpha-hydroxyvitamin D3 in vivo on human osteosarcomaQ41581472
Prolonged hypercalcaemia after industrial exposure to vitamin D3.Q41841677
Calcitriol (1,25-dihydroxycholecalciferol) enhances paclitaxel antitumor activity in vitro and in vivo and accelerates paclitaxel-induced apoptosis.Q43579777
A Phase I trial of pulse calcitriol in patients with refractory malignancies: pulse dosing permits substantial dose escalationQ43645557
Combination of 1alpha,25-dihydroxyvitamin D(3) with dexamethasone enhances cell cycle arrest and apoptosis: role of nuclear receptor cross-talk and Erk/Akt signaling.Q43829476
Cisplatin potentiates 1,25-dihydroxyvitamin D3-induced apoptosis in association with increased mitogen-activated protein kinase kinase kinase 1 (MEKK-1) expression.Q44255811
Pharmacokinetics of high-dose oral calcitriol: results from a phase 1 trial of calcitriol and paclitaxelQ44259177
Pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 in normal mice after systemic exposure to effective and safe antitumor dosesQ44805762
Pharmacokinetics and tolerability of a single dose of DN-101, a new formulation of calcitriol, in patients with cancerQ46797226
Importance of increased urinary calcium excretion in the development of secondary hyperparathyroidism of patients under glucocorticoid therapyQ51647891
A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors.Q53577477
Suppression of in vivo growth of human cancer solid tumor xenografts by 1,25-dihydroxyvitamin D3Q70156729
Antiproliferative responses to two human colon cancer cell lines to vitamin D3 are differently modified by 9-cis-retinoic acidQ70908424
Vitamin D3 analogue (EB 1089) inhibits in vitro cellular proliferation of human colon cancer cellsQ71213104
Enhancement of 1,25-dihydroxyvitamin D3-mediated antitumor activity with dexamethasoneQ74121283
1,25-Dihydroxycholecalciferol (1,25-D3) inhibits the growth of squamous cell carcinoma and down-modulates p21(Waf1/Cip1) in vitro and in vivoQ77861542
Phase I study of weekly DN-101, a new formulation of calcitriol, in patients with cancerQ79303399
P433issue1
P921main subjectpharmacokineticsQ323936
dexamethasoneQ422252
P304page(s)33-40
P577publication date2009-04-26
P1433published inCancer Chemotherapy and PharmacologyQ326137
P1476titleA phase I and pharmacokinetics study of intravenous calcitriol in combination with oral dexamethasone and gefitinib in patients with advanced solid tumors
P478volume65

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cites work (P2860)
Q347781611α,25-Dihydroxyvitamin D3-3β-bromoacetate, a potential cancer therapeutic agent: synthesis and molecular mechanism of action
Q84596826A phase I study of the vitamin D3 analogue ILX23-7553 administered orally to patients with advanced solid tumors
Q36799473A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer
Q34689137A vitamin D receptor-alkylating derivative of 1α,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer cells and suppresses tumor growth.
Q39670398Calcitriol (1,25-dihydroxycholecalciferol) enhances mast cell tumour chemotherapy and receptor tyrosine kinase inhibitor activity in vitro and has single-agent activity against spontaneously occurring canine mast cell tumours*
Q61023219Calcitriol and cancer therapy: A missed opportunity
Q26766242Calcitriol in Combination Therapy for Prostate Cancer: Pharmacokinetic and Pharmacodynamic Interactions
Q38020247Current progress in using vitamin D and its analogs for cancer prevention and treatment
Q41461266GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation
Q39282066Nitric oxide release from trigeminal satellite glial cells is attenuated by glial modulators and glutamate
Q50309039Oral bioavailability of DN101, a concentrated formulation of calcitriol, in tumor-bearing dogs
Q43158086Phase 2 trial of weekly intravenous 1,25 dihydroxy cholecalciferol (calcitriol) in combination with dexamethasone for castration-resistant prostate cancer
Q37761548The role of vitamin D in cancer prevention and treatment
Q38004753The role of vitamin D in cancer prevention and treatment
Q36509508Vitamin D and cancer: clinical aspects
Q26739735Vitamin D and urological cancers
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Q37803065Vitamin D supplementation: a pharmacologic perspective
Q37814083Vitamin D, disease and therapeutic opportunities
Q37061744Vitamin d: pharmacokinetics and safety when used in conjunction with the pharmaceutical drugs used in cancer patients: a systematic review

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