Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals

scientific article published on July 1996

Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI118754
P932PMC publication ID507406
P698PubMed publication ID8690781
P5875ResearchGate publication ID14511038

P2093author name stringC Cobelli
A Avogaro
S Del Prato
A Tiengo
A Valerio
G Toffolo
M Miola
P2860cites workThe glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitusQ28190307
Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with type 2 (non-insulin-dependent) diabetes mellitusQ28319139
Tracer-to-tracee ratio for analysis of stable isotope tracer data: link with radioactive kinetic formalismQ31004582
Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitusQ33889791
Lactate release from the subcutaneous tissue in lean and obese men.Q34119903
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistanceQ34577169
Relationship between insulin-mediated glucose disposal and lipid metabolism in man.Q34624238
V-A and A-V modes in whole body and regional kinetics: domain of validity from a physiological modelQ35444071
Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolismQ35818094
The theoretical bases of indirect calorimetry: a reviewQ39629809
Enzymatic microdetermination of serum free fatty acidsQ39692171
Glucose-Lactate Inter-Relations in ManQ39915500
Glycerol and lactate uptake in human forearmQ41172709
Contribution of liver and skeletal muscle to alanine and lactate metabolism in humansQ41210375
Lactate transport in skeletal muscle cells: uptake in L6 myoblastsQ41692899
Impact of glucose ingestion on hepatic and peripheral glucose metabolism in man: an analysis based on simultaneous use of the forearm and double isotope techniquesQ42661273
Evidence for lactate production by human adipose tissue in vivoQ43660130
Regulation of plasma lactate concentration in resting human subjectsQ43670719
Glucose and gluconeogenic substrate exchange by the forearm skeletal muscle in hyperglycemic and insulin-treated type II diabetic patientsQ44082653
Myocardial metabolism in insulin-deficient diabetic humans without coronary artery diseaseQ44911499
Ketone Body Metabolism in NIDDM: Effect of Sulfonylurea TreatmentQ46687889
Increased Rate of Cori Cycle in Obese Subjects With NIDDM and Effect of Weight ReductionQ47183976
Subcutaneous adipose tissue: a source of lactate production after glucose ingestion in humans.Q51615953
Metabolic characteristics of human adipose tissue in vivo.Q51621049
Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM.Q51621177
Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake.Q51621447
Measurement of pyruvate and lactate kinetics across the hindlimb and gut of anesthetized dogs.Q51629814
Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrateQ51664132
Type I diabetes is characterized by insulin resistance not only with regard to glucose, but also to lipid and amino acid metabolism.Q54427344
Skeletal muscle is a major site of lactate uptake and release during hyperinsulinemiaQ67745107
Muscle lactate transport studied in sarcolemmal giant vesicles: dependence on fibre type and ageQ67888517
Nonproductive exchanges: the use of isotopes gone astrayQ68129231
Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitusQ69664643
Lactate production cannot be measured with tracer techniquesQ69774275
The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterizationQ70196543
Ketone and lactate metabolism: an exchange of conclusionsQ70662405
Basal plasma insulin levels exert a qualitative but not quantitative effect on glucose-mediated glucose uptakeQ71878541
Lactate and pyruvate isotopic enrichments in plasma and tissues of postabsorptive and starved ratsQ72268067
Importance of the Hematocrit in Interpretation of Blood SugarQ72556502
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)108-115
P577publication date1996-07-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleIntracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals
P478volume98

Reverse relations

cites work (P2860)
Q37368112Adaptations to exercise training within skeletal muscle in adults with type 2 diabetes or impaired glucose tolerance: a systematic review
Q37139419Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training
Q35711899Alterations of glucose metabolism in type 2 diabetes mellitus. An overview
Q36854842Association of blood lactate with carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study
Q34354390Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study.
Q33891361Augmented pressor and sympathetic responses to skeletal muscle metaboreflex activation in type 2 diabetes patients
Q39481270Continuous measurement of subcutaneous lactate concentration during exercise by combining open-flow microperfusion and thin-film lactate sensors
Q51246632Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.
Q24678029Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans
Q42475231Endurance training alters basal erythrocyte MCT-1 contents and affects the lactate distribution between plasma and red blood cells in T2DM men following maximal exercise
Q52143152Ethanol inhalation on 1-[14C]-pyruvate kinetics in mice using a six-compartment closed model.
Q34235400Glucose and fatty acid metabolism in a 3 tissue in-vitro model challenged with normo- and hyperglycaemia
Q46387227Glucose clearance is higher in arm than leg muscle in type 2 diabetes
Q43794399Impaired sarcolemmal vesicle lactate uptake and skeletal muscle MCT1 and MCT4 expression in obese Zucker rats
Q34576075Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study
Q37547661Lactate, a Neglected Factor for Diabetes and Cancer Interaction.
Q35148800Metabolic and molecular basis of insulin resistance
Q35563398Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test
Q33668158Plasma lactate and diabetes risk in 8045 participants of the atherosclerosis risk in communities study
Q47697775Practical strategies for improving outcomes in T2DM: The potential role of pioglitazone and DPP4 inhibitors
Q44780501Pyruvate shuttling during rest and exercise before and after endurance training in men.
Q46452889Subacute static magnetic field exposure in rat induces a pseudoanemia status with increase in MCT4 and Glut4 proteins in glycolytic muscle.
Q22306221The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes

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