Amyloid-beta(1-42) fibrillar precursors are optimal for inducing tumor necrosis factor-alpha production in the THP-1 human monocytic cell line

scientific article published on September 2009

Amyloid-beta(1-42) fibrillar precursors are optimal for inducing tumor necrosis factor-alpha production in the THP-1 human monocytic cell line is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/BI9003777
P932PMC publication ID2749082
P698PubMed publication ID19694428
P5875ResearchGate publication ID26754973

P2093author name stringMichael R Nichols
Deepa Ajit
Geeta Paranjape
Maria L D Udan
P2860cites workRAGE and amyloid-beta peptide neurotoxicity in Alzheimer's diseaseQ24314906
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptideQ28131750
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivoQ28131779
Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell linesQ28297800
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesisQ29547501
Intracellular amyloid-beta in Alzheimer's diseaseQ29615626
Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrilsQ29617476
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's diseaseQ30432239
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaquesQ30486499
beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.Q31840031
Conformational Abs recognizing a generic amyloid fibril epitopeQ34009881
In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesisQ34166792
Intrathecal inflammation precedes development of Alzheimer's diseaseQ35476365
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's diseaseQ35689983
ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIAQ35869454
Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseasesQ35934211
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.Q35969894
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomersQ36178075
Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptideQ36684459
Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell lineQ40055691
Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.Q40056685
A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.Q40657503
Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's diseaseQ40870408
Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microgliaQ40897569
Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?Q40918121
Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alphaQ41132584
Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrilsQ41173971
beta-Amyloid induces increased release of interleukin-1 beta from lipopolysaccharide-activated human monocytesQ41195097
In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicityQ44418518
Amyloid-beta protofibrils differ from amyloid-beta aggregates induced in dilute hexafluoroisopropanol in stability and morphology.Q45140488
Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cellsQ46703067
Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.Q46733868
Solid state NMR reveals a pH-dependent antiparallel beta-sheet registry in fibrils formed by a beta-amyloid peptideQ47337531
The LPS receptor (CD14) links innate immunity with Alzheimer's diseaseQ47405789
Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's diseaseQ48157079
Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR.Q48219387
The importance of inflammatory mechanisms in Alzheimer diseaseQ48380991
Inflammation takes on Alzheimer disease.Q48495966
Growth of beta-amyloid(1-40) protofibrils by monomer elongation and lateral association. Characterization of distinct products by light scattering and atomic force microscopy.Q48614187
Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.Q48963826
Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.Q51811574
Activation of microglial cells by beta-amyloid protein and interferon-gamma.Q53202007
Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.Q53218877
Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.Q53248798
In vitro preparation of prefibrillar intermediates of amyloid-beta and alpha-synuclein.Q53371986
Amyloid fibril formation by A beta 16-22, a seven-residue fragment of the Alzheimer's beta-amyloid peptide, and structural characterization by solid state NMRQ57101951
Insights into the amyloid folding problem from solid-state NMRQ57188281
Observation of metastable Abeta amyloid protofibrils by atomic force microscopyQ73431442
Inflammatory factors are elevated in brain microvessels in Alzheimer's diseaseQ77384320
Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediatesQ78177648
P433issue38
P407language of work or nameEnglishQ1860
P304page(s)9011-9021
P577publication date2009-09-01
P1433published inBiochemistryQ764876
P1476titleAmyloid-beta(1-42) fibrillar precursors are optimal for inducing tumor necrosis factor-alpha production in the THP-1 human monocytic cell line
P478volume48

Reverse relations

cites work (P2860)
Q3944655214-3-3ε marks the amyloid-stimulated microglia long-term activation
Q42928266From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease
Q37419866Inflaming the diseased brain: a role for tainted melanins
Q36109443Isolated amyloid-β(1-42) protofibrils, but not isolated fibrils, are robust stimulators of microglia
Q35881879Nucleotides released from Aβ₁₋₄₂ -treated microglial cells increase cell migration and Aβ₁₋₄₂ uptake through P2Y₂ receptor activation
Q53347422Selective acetyl- and butyrylcholinesterase inhibitors reduce amyloid-β ex vivo activation of peripheral chemo-cytokines from Alzheimer's disease subjects: exploring the cholinergic anti-inflammatory pathway.
Q36489865Stability of early-stage amyloid-β(1-42) aggregation species
Q35327219The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease

Search more.