Conformational changes in Akt1 activation probed by amide hydrogen/deuterium exchange and nano-electrospray ionization mass spectrometry

scientific article published on July 2009

Conformational changes in Akt1 activation probed by amide hydrogen/deuterium exchange and nano-electrospray ionization mass spectrometry is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/RCM.4085
P932PMC publication ID2752348
P698PubMed publication ID19462409
P5875ResearchGate publication ID24446489

P2093author name stringBill X Huang
Hee-Yong Kim
Mingquan Guo
P2860cites workCrystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNPQ24318633
High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphateQ27639493
Crystal structure of an inactive Akt2 kinase domainQ27640282
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational changeQ27642001
Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphatesQ27643062
Role of translocation in the activation and function of protein kinase BQ28609902
The protein kinase B/Akt signalling pathway in human malignancyQ28645742
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase BQ28646376
Active and inactive protein kinases: structural basis for regulationQ29616320
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?Q29619633
Investigating protein structure and dynamics by hydrogen exchange MS.Q30328208
Insights into enzyme structure and dynamics elucidated by amide H/D exchange mass spectrometry.Q30349783
Probing the non-covalent structure of proteins by amide hydrogen exchange and mass spectrometryQ30426931
Phosphorylation causes subtle changes in solvent accessibility at the interdomain interface of methylesterase CheB.Q30662656
Ten years of protein kinase B signalling: a hard Akt to followQ34432885
Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interactionQ40957062
Akt activation by growth factors is a multiple-step process: the role of the PH domainQ42827602
Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cellsQ44906038
Interdomain conformational changes in Akt activation revealed by chemical cross-linking and tandem mass spectrometryQ46986547
Protein kinasesQ61640787
Latency and substrate binding globally reduce solvent accessibility of plasminogen activator inhibitor type 1 (PAI-1). An adaptation of PAI-1 conformer crystal structures by hydrogen-deuterium exchangeQ80508780
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectnanotechnologyQ11468
electrospray ionizationQ902061
P304page(s)1885-1891
P577publication date2009-07-01
P1433published inRapid Communications in Mass SpectrometryQ3419582
P1476titleConformational changes in Akt1 activation probed by amide hydrogen/deuterium exchange and nano-electrospray ionization mass spectrometry
P478volume23

Reverse relations

cites work (P2860)
Q36329614Effects of ethanol on conformational changes of Akt studied by chemical cross-linking, mass spectrometry, and (18)O labeling
Q33876709Elucidation of the binding sites of sodium dodecyl sulfate to β-lactoglobulin using hydrogen/deuterium exchange mass spectrometry combined with docking simulation
Q38057720Integration of phosphoproteomic, chemical, and biological strategies for the functional analysis of targeted protein phosphorylation

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