| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1018076908 |
| P356 | DOI | 10.1038/SJ.ONC.1201947 |
| P698 | PubMed publication ID | 9690513 |
| P5875 | ResearchGate publication ID | 13593757 |
| P2093 | author name string | McCormick F | |
| Feng J | |||
| Bellacosa A | |||
| Datta K | |||
| Chan TO | |||
| Stokoe D | |||
| Tsichlis P | |||
| Ahmed NN | |||
| Malstrom S | |||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 313-325 | |
| P577 | publication date | 1998-07-01 | |
| P1433 | published in | Oncogene | Q1568657 |
| P1476 | title | Akt activation by growth factors is a multiple-step process: the role of the PH domain | |
| P478 | volume | 17 |
| Q37537084 | 3-D structure and dynamics of protein kinase B-new mechanism for the allosteric regulation of an AGC kinase |
| Q32020545 | 3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth |
| Q63977266 | 5,7-Dihydroxy-3,4,6-trimethoxyflavone inhibits intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 via the Akt and nuclear factor-κB-dependent pathway, leading to suppression of adhesion of monocytes and eosinophils to bronchial |
| Q30008815 | A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling |
| Q57299362 | A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival |
| Q43918984 | A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis |
| Q93018670 | A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1 |
| Q33960388 | A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes |
| Q40364913 | A small molecule compound inhibits AKT pathway in ovarian cancer cell lines. |
| Q38218256 | AKT as a therapeutic target in multiple myeloma |
| Q40399045 | AKT capture by feline leukemia virus |
| Q35131182 | AKT phosphorylation is essential for insulin-induced relaxation of rat vascular smooth muscle cells |
| Q33944165 | AKT plays a central role in tumorigenesis |
| Q36977833 | AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion. |
| Q39791614 | AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K. |
| Q35747042 | AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells |
| Q44318970 | Abnormal PI3 kinase/Akt signal pathway in vagal afferent neurons and vagus nerve of streptozotocin-diabetic rats |
| Q58113811 | Abnormal activation of the Akt signaling pathway in adenoid cystic carcinoma |
| Q36376143 | Activated Akt protects the lung from oxidant-induced injury and delays death of mice |
| Q35971676 | Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury |
| Q36226730 | Activation of AKT kinases in cancer: implications for therapeutic targeting |
| Q33968347 | Activation of Akt by the bacterial inositol phosphatase, SopB, is wortmannin insensitive. |
| Q40120833 | Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition |
| Q40013835 | Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif. |
| Q51099941 | Adaptation to chronic continuous hypoxia potentiates Akt/HK2 anti-apoptotic pathway during brief myocardial ischemia/reperfusion insult. |
| Q44582560 | Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor |
| Q34151749 | Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1 |
| Q42525511 | Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts |
| Q34461246 | Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats. |
| Q37459965 | Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17. |
| Q34156036 | Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice |
| Q38850409 | Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response |
| Q24618410 | Akt phosphorylates and regulates the orphan nuclear receptor Nur77 |
| Q34936302 | Akt-induced phosphorylation of N-CoR at serine 1450 contributes to its misfolded conformational dependent loss (MCDL) in acute myeloid leukemia of the M5 subtype. |
| Q38495836 | Akt/PKB: one kinase, many modifications. |
| Q28574706 | Akt1 regulates a JNK scaffold during excitotoxic apoptosis |
| Q41859138 | Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. |
| Q36931366 | Allosteric properties of PH domains in Arf regulatory proteins |
| Q40846839 | Analysis of function and regulation of proteins that mediate signal transduction by use of lipid-modified plasma membrane-targeting sequences |
| Q24319153 | Angiogenin-induced protein kinase B/Akt activation is necessary for angiogenesis but is independent of nuclear translocation of angiogenin in HUVE cells |
| Q38068237 | Angiotensin-(1-7): beyond the cardio-renal actions. |
| Q34180196 | Angiotensin-induced EGF receptor transactivation inhibits insulin signaling in C9 hepatic cells. |
| Q38097532 | Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma |
| Q37285900 | Antioxidant-Rich Extract from Plantaginis Semen Ameliorates Diabetic Retinal Injury in a Streptozotocin-Induced Diabetic Rat Model |
| Q35115019 | Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and Akt/Bad/14-3-3γ in an Experimental Animal Model |
| Q40301975 | Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity |
| Q27642001 | Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change |
| Q45961245 | Biochemical and biological characterization of tumor-associated mutations of p110alpha. |
| Q28199393 | CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis |
| Q39716128 | CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis |
| Q52430921 | Cartilage oligomeric matrix protein is a prognostic factor and biomarker of colon cancer and promotes cell proliferation by activating the Akt pathway. |
| Q92534466 | Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling |
| Q30446892 | Caspase-3 activation as a bifurcation point between plasticity and cell death. |
| Q35879541 | Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways |
| Q33701947 | Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2 |
| Q34960781 | Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of rapamycin signaling and diminished PP2A activity |
| Q35387747 | Circadian gene hClock enhances proliferation and inhibits apoptosis of human colorectal carcinoma cells in vitro and in vivo |
| Q46691984 | Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth. |
| Q24316193 | ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization |
| Q80593389 | Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells |
| Q46973605 | Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells |
| Q43782774 | Common amino acid sequence motifs in p53, 14-3-3 and Akt protein families |
| Q37363611 | Conformational changes in Akt1 activation probed by amide hydrogen/deuterium exchange and nano-electrospray ionization mass spectrometry |
| Q42504933 | Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3. |
| Q61797375 | Coordination between TGF-β cellular signaling and epigenetic regulation during epithelial to mesenchymal transition |
| Q28252458 | Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators |
| Q27664839 | Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition |
| Q57589068 | Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway |
| Q28203143 | Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer |
| Q28586893 | Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4 |
| Q35632195 | Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2 |
| Q77527027 | Delayed mammary gland involution in MMTV-AKT1 transgenic mice |
| Q30529898 | Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex |
| Q27013647 | Developmental disease and cancer: biological and clinical overlaps |
| Q46724454 | Developmental regulation of protein kinase B activation is isoform specific in skeletal muscle of neonatal pigs |
| Q36739754 | Diabetes causes bone marrow endothelial barrier dysfunction by activation of the RhoA-Rho-associated kinase signaling pathway |
| Q44258491 | Differential mechanisms of constitutive Akt/PKB activation and its influence on gene expression in pancreatic cancer cells |
| Q35674485 | Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses |
| Q40839150 | Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells |
| Q42524332 | Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase |
| Q36436853 | Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers |
| Q35604279 | Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2 |
| Q36320680 | Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop. |
| Q37270455 | Drug discovery approaches targeting the PI3K/Akt pathway in cancer |
| Q98784824 | Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection |
| Q29615216 | ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions |
| Q36329614 | Effects of ethanol on conformational changes of Akt studied by chemical cross-linking, mass spectrometry, and (18)O labeling |
| Q36614997 | Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer |
| Q24622802 | Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development |
| Q36221405 | Enzyme Tunnels and Gates As Relevant Targets in Drug Design. |
| Q39752055 | Epidermal growth factor receptor signaling in nonsmall cell lung cancer |
| Q91790579 | ErbB-2 signaling in advanced prostate cancer progression and potential therapy |
| Q24323370 | Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling |
| Q36957010 | FANCI is a negative regulator of Akt activation |
| Q39735706 | FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts |
| Q34604380 | FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway |
| Q53686964 | FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis. |
| Q43246853 | FoxO genes are dispensable during gastrulation but required for late embryogenesis in Xenopus laevis |
| Q33333434 | Foxo1 directly regulates the transcription of recombination-activating genes during B cell development |
| Q46183163 | Functional proteomic analysis of a three-tier PKCepsilon-Akt-eNOS signaling module in cardiac protection |
| Q40410561 | Functional specificity of Sgk1 and Akt1 on ENaC activity |
| Q91759159 | GLS1 promotes proliferation in hepatocellular carcinoma cells via AKT/GSK3β/CyclinD1 pathway |
| Q40161268 | Gastrin-releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib |
| Q37180159 | Gastrointestinal growth factors and hormones have divergent effects on Akt activation. |
| Q64245765 | Getting the Akt Together: Guiding Intracellular Akt Activity by PI3K |
| Q42505146 | Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes |
| Q36088734 | Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress |
| Q27639493 | High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate |
| Q96950422 | Histoepigenetic analysis of the mesothelin network within pancreatic ductal adenocarcinoma cells reveals regulation of retinoic acid receptor gamma and AKT by mesothelin |
| Q45150005 | Human cytomegalovirus hyperimmune globulin not only neutralizes HCMV infectivity, but also inhibits HCMV-induced intracellular NF-kappaB, Sp1, and PI3-K signaling pathways |
| Q33842473 | Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling |
| Q35067891 | Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). |
| Q34132583 | IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects |
| Q36584347 | Identification and function of conformational dynamics in the multidomain GTPase dynamin |
| Q36334336 | Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion |
| Q42009639 | Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver |
| Q28244115 | Importin KPNA2, NBS1, DNA repair and tumorigenesis |
| Q34292978 | Improved ataxia telangiectasia mutated kinase inhibitor KU60019 provides a promising treatment strategy for non-invasive breast cancer |
| Q40656051 | Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand |
| Q37384680 | Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis |
| Q35022890 | Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia |
| Q45299979 | Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421. |
| Q28513945 | Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling |
| Q40803478 | Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase |
| Q47074406 | Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism |
| Q35834752 | Integrity of mTORC2 is dependent on the rictor Gly-934 site. |
| Q34770042 | Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. |
| Q30164872 | Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation |
| Q90574043 | Interaction of the N terminus of ADP-ribosylation factor with the PH domain of the GTPase-activating protein ASAP1 requires phosphatidylinositol 4,5-bisphosphate |
| Q46986547 | Interdomain conformational changes in Akt activation revealed by chemical cross-linking and tandem mass spectrometry |
| Q35584909 | Involvement of the Akt/PKB signaling pathway with disease processes |
| Q40642733 | JNK-interacting protein 1 promotes Akt1 activation. |
| Q35971438 | K63-linked ubiquitination in kinase activation and cancer |
| Q42799203 | Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts |
| Q35879915 | Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics |
| Q42823745 | Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation |
| Q41981828 | Localization of mTORC2 activity inside cells |
| Q47258279 | Long Noncoding RNA in Cancer: Wiring Signaling Circuitry |
| Q91637407 | Loss of Glutamate Decarboxylase 67 in Somatostatin-Expressing Neurons Leads to Anxiety-Like Behavior and Alteration in the Akt/GSK3β Signaling Pathway |
| Q81236490 | Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer |
| Q28397511 | Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium |
| Q22009114 | MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1 |
| Q42811250 | Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. |
| Q37943416 | Mammalian TOR signaling to the AGC kinases |
| Q28568275 | Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation |
| Q33958737 | Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase |
| Q41082747 | MicroRNA-23b functions as an oncogene and activates AKT/GSK3β/β-catenin signaling by targeting ST7L in hepatocellular carcinoma |
| Q36022236 | MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer |
| Q36002858 | Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB. |
| Q39961067 | Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death |
| Q36677829 | Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1. |
| Q34057438 | Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain |
| Q35884861 | Molecular mechanisms for age-associated mitochondrial deficiency in skeletal muscle. |
| Q34976965 | Multiple host kinases contribute to Akt activation during Salmonella infection |
| Q30423008 | Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein |
| Q36512798 | Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner |
| Q36908289 | Myocardial AKT: the omnipresent nexus |
| Q37170896 | Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B. |
| Q28393889 | NF-κB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1 |
| Q24308684 | NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma |
| Q39089022 | NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription |
| Q33948870 | Natural biology of polyomavirus middle T antigen |
| Q33761629 | Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head |
| Q33882138 | Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain |
| Q37750871 | Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin. |
| Q28263138 | Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt |
| Q24305925 | P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation |
| Q34467820 | PDK2: a complex tail in one Akt. |
| Q36321986 | PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells |
| Q54113534 | PI3K/AKT/mTOR pathway inhibitors inhibit the growth of melanoma cells with mTOR H2189Y mutations in vitro. |
| Q36917818 | PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling. |
| Q39398876 | PTMScan direct: identification and quantification of peptides from critical signaling proteins by immunoaffinity enrichment coupled with LC-MS/MS. |
| Q24316409 | Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis |
| Q33555724 | Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice |
| Q37356550 | Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation |
| Q34271064 | Perifosine as a potential novel anti-cancer agent inhibits EGFR/MET-AKT axis in malignant pleural mesothelioma |
| Q42117125 | Phosphatidylinositol 3-kinase-dependent activation of mammalian protein kinase B/Akt in Saccharomyces cerevisiae, an in vivo model for the functional study of Akt mutations |
| Q34712409 | Phosphatidylserine is a critical modulator for Akt activation |
| Q40106325 | Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains |
| Q36739429 | Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke |
| Q40769024 | Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death |
| Q40484925 | Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry |
| Q42636496 | Phosphorylation site mapping of endogenous proteins: a combined MS and bioinformatics approach. |
| Q33422611 | Photo-activation of the hydrophobic probe iodonaphthylazide in cells alters membrane protein function leading to cell death |
| Q28748305 | Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase |
| Q33680673 | Physiological regulation of Akt activity and stability. |
| Q37291966 | Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein |
| Q42563391 | Probing Akt-inhibitor interaction by chemical cross-linking and mass spectrometry |
| Q39691093 | Programmed cell death 4 (PDCD4) enhances the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by inhibiting the PI3K/Akt signaling pathway |
| Q40529888 | Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells |
| Q28217312 | Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI |
| Q36954156 | Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation |
| Q42436985 | Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages |
| Q33738185 | Purification and characterization of recombinant CH3 domain fragment of the CREB-binding protein |
| Q28541545 | Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets |
| Q46898192 | RET ligand-induced internalization and its consequences for downstream signaling. |
| Q28580317 | Ras GTPase-activating protein binds to Akt and is required for its activation |
| Q47577112 | Reciprocal regulation of MelCAM and AKT in human melanoma |
| Q24319987 | Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions |
| Q41930376 | Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging |
| Q24314300 | Regulated association of protein kinase B/Akt with breast tumor kinase |
| Q34799443 | Regulation of Akt signaling activation by ubiquitination |
| Q30100963 | Regulation of PI3K/Akt dependent apoptotic markers during b virus infection of human and macaque fibroblasts. |
| Q37081895 | Regulation of a third conserved phosphorylation site in SGK1 |
| Q28210107 | Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site |
| Q35031770 | Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm |
| Q36313167 | Regulation of the Akt kinase by interacting proteins |
| Q44532350 | Relevance of Akt phosphorylation in cell transformation induced by Jaagsiekte sheep retrovirus |
| Q43785527 | Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway |
| Q42026999 | Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling. |
| Q38189089 | Role of spleen tyrosine kinase in the pathogenesis of chronic lymphocytic leukemia |
| Q46025873 | Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway |
| Q33683189 | Signal transduction pathways that regulate the fate of B lymphocytes. |
| Q34349115 | Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cells |
| Q37417611 | Site-specific activation of AKT protects cells from death induced by glucose deprivation |
| Q42813355 | Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit |
| Q36388832 | Snail1 controls TGF-β responsiveness and differentiation of mesenchymal stem cells. |
| Q34240979 | Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha |
| Q33921367 | Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production. |
| Q34778203 | TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation |
| Q40795252 | TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway |
| Q23910293 | TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages |
| Q37674624 | Targeted therapy of hepatocellular cancer. |
| Q89973548 | Targeting AKT/PKB to improve treatment outcomes for solid tumors |
| Q36141097 | Targeting drivers of melanoma with synthetic small molecules and phytochemicals |
| Q37068767 | Targeting genomic alterations in squamous cell lung cancer |
| Q37872655 | Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs |
| Q24670140 | Tcl1 enhances Akt kinase activity and mediates its nuclear translocation |
| Q34116730 | The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane |
| Q37549798 | The Akt kinases: isoform specificity in metabolism and cancer |
| Q41886997 | The Akt pathway is involved in rapid ischemic tolerance in focal ischemia in Rats |
| Q36163034 | The B-cell receptor signaling pathway as a therapeutic target in CLL. |
| Q92074035 | The Binding of PD-L1 and Akt Facilitates Glioma Cell Invasion Upon Starvation via Akt/Autophagy/F-Actin Signaling |
| Q24310343 | The E3 ligase TRAF6 regulates Akt ubiquitination and activation |
| Q33940458 | The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase. |
| Q40252087 | The Inhibitory Effect of Nodakenin on Mast-Cell-Mediated Allergic Inflammation Via Downregulation of NF-κB and Caspase-1 Activation. |
| Q39636381 | The PI3 kinase/mTOR blocker NVP-BEZ235 overrides resistance against irreversible ErbB inhibitors in breast cancer cells. |
| Q89586588 | The PI3K pathway impacts stem gene expression in a set of glioblastoma cell lines |
| Q33327777 | The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation |
| Q33770769 | The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors |
| Q34924913 | The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation |
| Q33599964 | The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway |
| Q98192784 | The Structural Determinants of PH Domain-Mediated Regulation of Akt Revealed by Segmental Labeling |
| Q39454531 | The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase |
| Q36758478 | The akt kinase: molecular determinants of oncogenicity |
| Q28083266 | The biology behind PI3K inhibition in chronic lymphocytic leukaemia |
| Q43409987 | The calcineurin-nuclear factor of activated T cells signaling pathway mediates the effect of corticotropin releasing factor and urocortins on catecholamine synthesis |
| Q42797373 | The dynamics of protein kinase B regulation during B cell antigen receptor engagement |
| Q33914706 | The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein. |
| Q42829672 | The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret. |
| Q28587901 | The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C |
| Q43581654 | The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway |
| Q29547860 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer |
| Q36002875 | The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection. |
| Q24318686 | The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway |
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