Hyperglycemia induces differential change in oxidative stress at gene expression and functional levels in HUVEC and HMVEC.

scientific article published on 05 October 2013

Hyperglycemia induces differential change in oxidative stress at gene expression and functional levels in HUVEC and HMVEC. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1038375852
P356DOI10.1186/1475-2840-12-142
P932PMC publication ID3851327
P698PubMed publication ID24093550
P5875ResearchGate publication ID257460471

P50authorHemang PatelQ37370664
P2093author name stringJuan Chen
Mahendra Kavdia
Kumuda C Das
P2860cites workBiochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular systemQ26991619
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt siteQ28363492
Subcellular localization of Nox4 and regulation in diabetesQ28566200
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damageQ29616101
Heme oxygenase-1 protects retinal endothelial cells against high glucose- and oxidative/nitrosative stress-induced toxicityQ31083347
Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in miceQ33565541
Endothelial dysfunction as a target for prevention of cardiovascular diseaseQ33610670
Assessment and treatment of endothelial dysfunction in humansQ33731648
Endothelial NO and O₂·⁻ production rates differentially regulate oxidative, nitroxidative, and nitrosative stress in the microcirculationQ33732455
Metabolic memory: a vascular perspectiveQ34158068
Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucoseQ34489884
Effects of antihypertensive drugs on endothelial dysfunction: clinical implicationsQ34510978
Differential analyses of angiogenesis and expression of growth factors in micro- and macrovascular endothelial cells of type 2 diabetic rats.Q54774978
Differential expression and responsiveness of chemokine receptors (CXCR1-3) by human microvascular endothelial cells and umbilical vein endothelial cellsQ56890926
Effect of High Glucose on Nitric Oxide Production and Endothelial Nitric Oxide Synthase Protein Expression in Human Glomerular Endothelial CellsQ79279986
Oxidative stress and endothelial function: therapeutic interventionsQ83934632
Impact of SOD in eNOS uncoupling: a two-edged sword between hydrogen peroxide and peroxynitriteQ85011752
Endothelial cells (ECs) for vascular tissue engineering: venous ECs are less thrombogenic than arterial ECsQ85488090
The UCP1 -3826A/G polymorphism is associated with diabetic retinopathy and increased UCP1 and MnSOD2 gene expression in human retinaQ87406484
Free radicals, diabetes and endothelial dysfunction.Q34722600
Modeling of biopterin-dependent pathways of eNOS for nitric oxide and superoxide production.Q35252245
Global profiling of reactive oxygen and nitrogen species in biological systems: high-throughput real-time analysesQ35728023
Endothelial dysfunction: cardiovascular risk factors, therapy, and outcomeQ36012867
Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequencesQ36189782
Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complicationsQ36690229
Mitochondrial reactive oxygen species-mediated signaling in endothelial cellsQ36712703
Insights into the regulation of protein abundance from proteomic and transcriptomic analysesQ36846022
Interactions between microvascular and macrovascular disease in diabetes: pathophysiology and therapeutic implications.Q36966063
Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidaseQ37731341
Diabesity: therapeutic optionsQ37762294
Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseasesQ37785105
Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stressQ37976675
Cell oxidant stress delivery and cell dysfunction onset in type 2 diabetes.Q37983925
Vascular memory: can we broaden the concept of the metabolic memory?Q38006502
Contribution of oxidative stress to endothelial dysfunction in hypertensionQ38066208
Hyperglycemia and vascular metabolic memory: truth or fiction?Q38086111
Resveratrol protects vascular endothelial cells from high glucose-induced apoptosis through inhibition of NADPH oxidase activation-driven oxidative stressQ39144504
Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926.Q39260102
Hyperglycemia and oxidative stress in cultured endothelial cells--a comparison of primary endothelial cells with an immortalized endothelial cell line.Q39361437
Different modulation of dipeptidyl peptidase-4 activity between microvascular and macrovascular human endothelial cellsQ39705884
NO/peroxynitrite dynamics of high glucose-exposed HUVECs: chemiluminescent measurement and computational modelQ39861568
Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular diseaseQ39960465
Proteomic profiling of human retinal and choroidal endothelial cells reveals molecular heterogeneity related to tissue of origin.Q40144267
Differential effects of curcumin on vasoactive factors in the diabetic rat heart.Q42075250
Analysis of kinetics of dihydroethidium fluorescence with superoxide using xanthine oxidase and hypoxanthine assayQ42728626
Rapid and specific measurements of superoxide using fluorescence spectroscopyQ42962950
Total and cardiovascular disease mortality predicted by metabolic syndrome is inferior relative to its componentsQ42972070
Oxidative stress in response to high glucose levels in endothelial cells and in endothelial progenitor cells: evidence for differential glutathione peroxidase-1 expression.Q43062551
Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.Q43823904
Hyperglycemia reduces nitric oxide synthase and glycogen synthase activity in endothelial cellsQ44180582
Effects of endomorphins on human umbilical vein endothelial cells under high glucoseQ44983617
High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation.Q45027017
Hydrogen peroxide acts as both vasodilator and vasoconstrictor in the control of perfused mouse mesenteric resistance arteriesQ45270242
Ascorbic acid and uric acid suppress glucose-induced fibronectin and vascular endothelial growth factor production in human endothelial cellsQ45298767
Critical effect of VEGF in the process of endothelial cell apoptosis induced by high glucoseQ46379963
Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitriteQ46974160
Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo.Q47254622
C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells.Q53231716
P407language of work or nameEnglishQ1860
P921main subjecthyperglycemiaQ271993
oxidative stressQ898814
P304page(s)142
P577publication date2013-10-05
P1433published inCardiovascular DiabetologyQ2468083
P1476titleHyperglycemia induces differential change in oxidative stress at gene expression and functional levels in HUVEC and HMVEC.
P478volume12

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cites work (P2860)
Q39565276A microdialysis method to measure in vivo hydrogen peroxide and superoxide in various rodent tissues.
Q89805334Antioxidant and Anti-Inflammatory Properties of Cherry Extract: Nanosystems-Based Strategies to Improve Endothelial Function and Intestinal Absorption
Q38993830Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha
Q41922933Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser(1177)/Thr(497) of endothelial nitric oxide synthase in diabetic mice
Q35278126Beneficial effect of troxerutin on diabetes-induced vascular damages in rat aorta: histopathological alterations and antioxidation mechanism
Q34708380Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy
Q54982064CD40-mediated HIF-1α expression underlying microangiopathy in diabetic nerve pathology.
Q27342723Canonical and noncanonical vascular endothelial growth factor pathways: new developments in biology and signal transduction
Q64063033Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
Q64260539Carnosol as a Nrf2 Activator Improves Endothelial Barrier Function Through Antioxidative Mechanisms
Q40105411Comparative effects of microvascular and macrovascular disease on the risk of major outcomes in patients with type 2 diabetes
Q46246551Decreased EDHF-mediated relaxation is a major mechanism in endothelial dysfunction in resistance arteries in aged mice on prolonged high-fat sucrose diet
Q36775423Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model
Q28068603Diabetes mellitus and oxidative stress-A concise review
Q92510963ERβ Accelerates Diabetic Wound Healing by Ameliorating Hyperglycemia-Induced Persistent Oxidative Stress
Q34324055Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal
Q35858496Genetic risk factors affecting mitochondrial function are associated with kidney disease in people with Type 1 diabetes.
Q91660619Hedgehog pathway inhibition causes primary follicle atresia and decreases female germline stem cell proliferation capacity or stemness
Q37347292High Glucose Induces Reactivation of Latent Kaposi's Sarcoma-Associated Herpesvirus
Q36195357Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq
Q51766095Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells.
Q41870337Induced peroxidase and cytoprotective enzyme expressions support adaptation of HUVECs to sustain subsequent H2O2 exposure
Q36274208Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization?
Q111441864Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions
Q38575779Markers of Oxidative Stress during Diabetes Mellitus.
Q46373924Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked?
Q36847079MicroRNAs in Hyperglycemia Induced Endothelial Cell Dysfunction
Q37595822Nitrones reverse hyperglycemia-induced endothelial dysfunction in bovine aortic endothelial cells
Q35073993Plasma extracellular superoxide dismutase concentration, allelic variations in the SOD3 gene and risk of myocardial infarction and all-cause mortality in people with type 1 and type 2 diabetes
Q34432247Polyphenol fraction of extra virgin olive oil protects against endothelial dysfunction induced by high glucose and free fatty acids through modulation of nitric oxide and endothelin-1.
Q59792692Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies
Q38478574ROS signaling and redox biology in endothelial cells
Q37726715The effect of alogliptin on pulmonary function in obese patients with type 2 diabetes inadequately controlled by metformin monotherapy
Q46708553The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice
Q39223951The use of human umbilical vein endothelial cells (HUVECs) as an in vitro model to assess the toxicity of nanoparticles to endothelium: a review
Q92923522Vascular Endothelium in Neonatal Sepsis: Basic Mechanisms and Translational Opportunities
Q88985401Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy
Q33684215Vascular endothelial growth factor-D modulates oxidant-antioxidant balance of human vascular endothelial cells

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