Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity

scientific article published on 24 October 2013

Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.IMMUNI.2013.10.006
P932PMC publication ID3852615
P698PubMed publication ID24210353
P5875ResearchGate publication ID258427272

P50authorRuslan MedzhitovQ517459
P2093author name stringShuang Yu
Dominik D Schenten
Esther Florsheim
Noah W Palm
Rachel K Rosenstein
P2860cites workIL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokinesQ24294720
Development and function of group 2 innate lymphoid cellsQ26862916
Insights into the initiation of type 2 immune responsesQ26865705
Approaching the asymptote? Evolution and revolution in immunologyQ28274344
The function of allergy: immunological defense against toxinsQ28284387
IL-33, a potent inducer of adaptive immunity to intestinal nematodesQ28505946
Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain geneQ28588495
Molecular mechanisms of necroptosis: an ordered cellular explosionQ29616004
Immunological and inflammatory functions of the interleukin-1 familyQ29619669
New paradigms in type 2 immunityQ33835435
Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens.Q33904042
A mechanism for the initiation of allergen-induced T helper type 2 responsesQ34010133
Necroptosis: the release of damage-associated molecular patterns and its physiological relevanceQ34035754
RETRACTED: Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.Q34085160
Systemic immediate allergic reactions to arthropod stings and bitesQ34396469
Mast cells can enhance resistance to snake and honeybee venomsQ34551900
Bee and wasp venomsQ34696260
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in miceQ35370039
Interleukin 33 as a mechanically responsive cytokine secreted by living cellsQ35838985
Proteases in helminth- and allergen- induced inflammatory responsesQ36279678
Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralisQ36804679
Trypanosoma cruzi infection is enhanced by vector saliva through immunosuppressant mechanisms mediated by lysophosphatidylcholineQ36974519
The molecular basis of allergenicity.Q37308451
Phospholipase A2 structure/function, mechanism, and signalingQ37326136
Pattern recognition receptors and control of adaptive immunityQ37361471
The toxicogenomic multiverse: convergent recruitment of proteins into animal venomsQ37565656
New insights into innate immune mechanisms underlying allergenicityQ37662191
The enigmatic processing and secretion of interleukin-33.Q37715704
Insect venomsQ37762375
Mechanisms of immunotherapy to wasp and bee venomQ37897667
IL-33: a Janus cytokineQ37998317
Allergy to insect stings. II. Phospholipase A: the major allergen in honeybee venomQ39360873
Venoms, antivenoms and immunotherapyQ40851422
Allergic host defencesQ41190858
Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivoQ42529079
T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responsesQ42944108
Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mitesQ44276703
Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporterQ46062240
The significance of the mast cell response to bee venomQ52500091
Immunity of bee keepers to some constituents of bee venom: phospholipase-A antibodies.Q52625336
Mast cells and local resistance to Russell's viper venomQ69980076
A link between catalytic activity, IgE-independent mast cell activation, and allergenicity of bee venom phospholipase A2Q71707099
IL-33-activated dendritic cells are critical for allergic airway inflammationQ83790505
Characterization of allergens in four South American snake speciesQ83991552
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectvenomQ3386847
P304page(s)976-985
P577publication date2013-10-24
P1433published inImmunityQ6005457
P1476titleBee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity
P478volume39

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cites work (P2860)
Q38241536A Question of Nature: Some Antigens are Bound to be Allergens
Q35289292A single glycan on IgE is indispensable for initiation of anaphylaxis.
Q37611447A tissue checkpoint regulates type 2 immunity.
Q33581103Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa
Q38239279Antibodies as natural adjuvants.
Q52762094Antibodies: taking the sting out.
Q39265436Are Mast Cells MASTers in Cancer?
Q33857994Are ticks venomous animals?
Q46253139B Cell Intrinsic Mechanisms Constraining IgE Memory.
Q34372070B cells regulate CD4+ T cell responses to papain following B cell receptor-independent papain uptake
Q45974348Bee Venom Phospholipase A2, a Novel Foxp3+ Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating Neuroinflammatory Responses in a Mouse Model of Parkinson's Disease.
Q26767063Bee Venom Phospholipase A2: Yesterday's Enemy Becomes Today's Friend
Q35493627Bee venom phospholipase A2 protects against acetaminophen-induced acute liver injury by modulating regulatory T cells and IL-10 in mice
Q36410600Bee venom phospholipase A2 suppresses allergic airway inflammation in an ovalbumin-induced asthma model through the induction of regulatory T cells
Q26865509Beneficial autoimmunity at body surfaces - immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer
Q41727136Cancer research meets tick vectors for infectious diseases
Q55012882Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy.
Q42494705Controversial role of mast cells in skin cancers
Q64071386Dose-Dependent Neuroprotective Effect of Standardized Bee Venom Phospholipase A Against MPTP-Induced Parkinson's Disease in Mice
Q36414954Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils.
Q36264141Enhanced transcriptomic responses in the Pacific salmon louse Lepeophtheirus salmonis oncorhynchi to the non-native Atlantic Salmon Salmo salar suggests increased parasite fitness
Q52725595Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33.
Q58045445Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response
Q36983081Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases
Q90566186Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation
Q90357108Function of secreted phospholipase A2 group-X in asthma and allergic disease
Q91772545Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care
Q33559067GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen
Q38229984Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin.
Q34257404Human CD117 (cKit)+ innate lymphoid cells have a discrete transcriptional profile at homeostasis and are expanded during filarial infection
Q40467026IL-1R1-MyD88 axis elicits papain-induced lung inflammation.
Q35832890IL-3 synergises with basophil-derived IL-4 and IL-13 to promote the alternative activation of human monocytes.
Q33992276IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure
Q88125512IL-33 meets allergens at the gate
Q40603304Identification of Epithelial Phospholipase A2 Receptor 1 as a Potential Target in Asthma
Q92027568IgE Glycosylation in Health and Disease
Q38844328IgE and mast cells in host defense against parasites and venoms
Q36469735IgE antibodies, FcεRIα, and IgE-mediated local anaphylaxis can limit snake venom toxicity.
Q36025549IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses
Q38994739Immunoglobulin Glycosylation Effects in Allergy and Immunity
Q38797790Indigo Naturalis Ameliorates Oxazolone-Induced Dermatitis but Aggravates Colitis by Changing the Composition of Gut Microflora
Q47285890Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family.
Q47117344Macropis fulvipes Venom component Macropin Exerts its Antibacterial and Anti-Biofilm Properties by Damaging the Plasma Membranes of Drug Resistant Bacteria
Q41112447Mast Cells and IgE can Enhance Survival During Innate and Acquired Host Responses to Venoms
Q26775969Mast cells and IgE in defense against venoms: Possible "good side" of allergy?
Q99419174Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
Q89947583Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response
Q64963613Modulation of Mast Cell Reactivity by Lipids: The Neglected Side of Allergic Diseases.
Q36539857Potential effector and immunoregulatory functions of mast cells in mucosal immunity
Q37378862Protective Effects of Intratracheally-Administered Bee Venom Phospholipase A2 on Ovalbumin-Induced Allergic Asthma in Mice.
Q36946923Regulatory T Cells Contribute to the Inhibition of Radiation-Induced Acute Lung Inflammation via Bee Venom Phospholipase A₂ in Mice.
Q27027694Regulatory constraints in the generation and differentiation of IgE-expressing B cells
Q57069225Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44
Q47334197Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen
Q35139991Skin exposure promotes a Th2-dependent sensitization to peanut allergens
Q41367020Stingray venom activates IL-33 producing cardiomyocytes, but not mast cell, to promote acute neutrophil-mediated injury
Q28085379Testing the 'toxin hypothesis of allergy': mast cells, IgE, and innate and acquired immune responses to venoms
Q35828990The Extracellular Domains of IgG1 and T Cell-Derived IL-4/IL-13 Are Critical for the Polyclonal Memory IgE Response In Vivo
Q36509214The Mast Cell-IgE Paradox: From Homeostasis to Anaphylaxis
Q35994584The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease
Q39181842The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals
Q38987762The Roles of the Secreted Phospholipase A2 Gene Family in Immunology
Q58695426The allergic response mediated by fire ant venom proteins
Q64988741The functional biology of peanut allergens and possible links to their allergenicity.
Q34391415The interleukin-1 family: back to the future
Q47810222The pathophysiology of anaphylaxis
Q52608299The role of extracellular vesicles when innate meets adaptive.
Q38224933The route to pathologies in chronic inflammatory diseases characterized by T helper type 2 immune cells.
Q35894698Therapeutic Effects of Bee Venom on Immunological and Neurological Diseases
Q35079476Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33.
Q56984099Une réponse allergique pour lutter contre les venins
Q38491546What makes an allergen?
Q42957096Why do we study animal toxins?