Limited dissemination of pathogenic SIV after vaginal challenge of rhesus monkeys immunized with a live, attenuated lentivirus

scientific article published on 03 August 2009

Limited dissemination of pathogenic SIV after vaginal challenge of rhesus monkeys immunized with a live, attenuated lentivirus is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2009.06.052
P932PMC publication ID2754392
P698PubMed publication ID19647847
P5875ResearchGate publication ID26710246

P50authorMeritxell Genescà FerrerQ42843555
P2093author name stringChristopher J Miller
Linda Fritts
Michael B McChesney
Zhong-Min Ma
Mars Stone
Shelley Blozois
P2860cites workMechanisms of protection induced by attenuated simian immunodeficiency virus. II. Lymphocyte depletion does not abrogate protection.Q45753829
Immunophenotypic characterization of simian immunodeficiency virus-infected dendritic cells in cervix, vagina, and draining lymph nodes of rhesus monkeys.Q45756492
Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells.Q45785662
The development of PCR based assays for the detection and differentiation of simian immunodeficiency virus in vivoQ45785963
Protection of macaques against a SHIV with a homologous HIV-1 Env and a pathogenic SHIV-89.6P with a heterologous Env by vaccination with multiple gene-deleted SHIVs.Q54068533
Simian-human immunodeficiency virus SHIV89.6-induced protection against intravaginal challenge with pathogenic SIVmac239 is independent of the route of immunization and is associated with a combination of cytotoxic T-lymphocyte and alpha interferonQ72992207
Live attenuated AIDS viruses as vaccines: promise or peril?Q33776149
Pathogenic simian/human immunodeficiency virus SHIV(KU) inoculated into immunized macaques caused infection, but virus burdens progressively declined with timeQ33787256
Evidence for recombination of live, attenuated immunodeficiency virus vaccine with challenge virus to a more virulent strain.Q33802066
Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cellsQ33806915
Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239.Q35877932
Live, attenuated simian immunodeficiency virus vaccines elicit potent resistance against a challenge with a human immunodeficiency virus type 1 chimeric virus.Q35897786
Protective attenuated lentivirus immunization induces SIV-specific T cells in the genital tract of rhesus monkeys.Q36105923
Antiviral CD8+ T cells in the genital tract control viral replication and delay progression to AIDS after vaginal SIV challenge in rhesus macaques immunized with virulence attenuated SHIV 89.6.Q36105929
Depo-Provera abrogates attenuated lentivirus-induced protection in male rhesus macaques challenged intravenously with pathogenic SIVmac239.Q36105933
A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge.Q36636854
Gamma interferon-mediated inflammation is associated with lack of protection from intravaginal simian immunodeficiency virus SIVmac239 challenge in simian-human immunodeficiency virus 89.6-immunized rhesus macaquesQ36942556
Macaques vaccinated with live-attenuated SIV control replication of heterologous virusQ36946545
With minimal systemic T-cell expansion, CD8+ T Cells mediate protection of rhesus macaques immunized with attenuated simian-human immunodeficiency virus SHIV89.6 from vaginal challenge with simian immunodeficiency virus.Q36949843
Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.Q37273233
Persistence of pathogenic challenge virus in macaques protected by simian immunodeficiency virus SIVmacDeltanefQ39602002
Characterization of simian and human immunodeficiency chimeric viruses re-isolated from vaccinated macaque monkeys after challenge infectionQ40719269
Superinfection of HIV-2-preinfected macaques after rectal exposure to a primary isolate of SIVmac251.Q41184851
Efficacy of a SHIV 89.6 proviral DNA vaccine against mucosal SIVmac239 challengeQ44111091
Resistance to superinfection by a vigorously replicating, uncloned stock of simian immunodeficiency virus (SIVmac251) stimulates replication of a live attenuated virus vaccine (SIVmacC8).Q45391784
Protection against late-onset AIDS in macaques prophylactically immunized with a live simian HIV vaccine was dependent on persistence of the vaccine virusQ45591866
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectimmunizationQ1415366
attenuated vaccineQ1810913
P304page(s)260-270
P577publication date2009-08-03
P1433published inVirologyQ7934867
P1476titleLimited dissemination of pathogenic SIV after vaginal challenge of rhesus monkeys immunized with a live, attenuated lentivirus
P478volume392

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cites work (P2860)
Q36155560Antiviral antibodies and T cells are present in the foreskin of simian immunodeficiency virus-infected rhesus macaques
Q35250925Characterization of an effective CTL response against HIV and SIV infections
Q37856708Coming of age: reconstruction of heterosexual HIV-1 transmission in human ex vivo organ culture systems
Q36760147Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies
Q33547467Depo-provera treatment does not abrogate protection from intravenous SIV challenge in female macaques immunized with an attenuated AIDS virus.
Q33725546Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo
Q27323257In captive rhesus macaques, cervicovaginal inflammation is common but not associated with the stable polymicrobial microbiome
Q35353641Increased inherent intestinal granzyme B expression may be associated with SIV pathogenesis in Asian non-human primates.
Q36154801Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge.
Q35826525Low-dose penile SIVmac251 exposure of rhesus macaques infected with adenovirus type 5 (Ad5) and then immunized with a replication-defective Ad5-based SIV gag/pol/nef vaccine recapitulates the results of the phase IIb step trial of a similar HIV-1 va
Q36827361Mucosal priming with a replicating-vaccinia virus-based vaccine elicits protective immunity to simian immunodeficiency virus challenge in rhesus monkeys
Q33767191New directions for HIV vaccine development from animal models
Q34548621Preventing mucosal HIV transmission with topical microbicides: challenges and opportunities
Q28818806Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine
Q37810622Role of Semen in HIV‐1 Transmission: Inhibitor or facilitator?
Q92736069T Cells in the Female Reproductive Tract Can Both Block and Facilitate HIV Transmission
Q33666002Use of nonhuman primate models to develop mucosal AIDS vaccines
Q35022735Viral RNA levels and env variants in semen and tissues of mature male rhesus macaques infected with SIV by penile inoculation

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