Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c

scientific article published on 05 September 2016

Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NN.4380
P932PMC publication ID5083203
P698PubMed publication ID27595386

P50authorSvante PääboQ170342
Ann GraybielQ4766422
Cheng-Ting ChienQ61090009
Wolfgang EnardQ61128341
Wulf HeversQ110965689
P2093author name stringHiroshi Takahashi
Fu-Chin Liu
Ulrich Bornschein
Yi-Hsin Lee
Sin-Jhong Cheng
Yi-Chuan Chen
Shih-Yun Chen
Yun-Chia Chou
Kuan-Ming Lu
Hao-Yu Yang
Hsiao-Ying Kuo
Gui-May Chen
Jing-Ruei Lin
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Postnatal Loss of Mef2c Results in Dissociation of Effects on Synapse Number and Learning and MemoryQ39999607
MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.Q40817289
Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiationQ43699789
Dopamine receptor activation is required for corticostriatal spike-timing-dependent plasticity.Q46717148
Refining the phenotype associated with MEF2C haploinsufficiency.Q48227906
Molecular characterization of the intercalated cell masses of the amygdala: implications for the relationship with the striatumQ48381573
Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis.Q48413469
Early patterning of prelimbic cortical axons to the striatal patch compartment in the neonatal mouseQ48417750
The sequence of formation and development of corticostriate connections in miceQ48417758
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization.Q48691508
Striatal volume on magnetic resonance imaging and repetitive behaviors in autismQ48866759
Autistic phenotype from MEF2C knockout cellsQ50344028
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95Q24306675
A functional genetic link between distinct developmental language disordersQ24312638
The human language-associated gene SRPX2 regulates synapse formation and vocalization in miceQ24339037
Altered ultrasonic vocalization in mice with a disruption in the Foxp2 geneQ24530590
Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficitsQ24594611
Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactionsQ24603791
Neural basis of an inherited speech and language disorder.Q24643907
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivoQ24644531
MeCP2, a key contributor to neurological disease, activates and represses transcriptionQ24647533
Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brainQ24648621
Identifying autism loci and genes by tracing recent shared ancestryQ24655308
Patterns and rates of exonic de novo mutations in autism spectrum disordersQ28264242
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse numberQ28297899
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and functionQ28507026
In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survivalQ28508411
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxietyQ29615160
A humanized version of Foxp2 affects cortico-basal ganglia circuits in miceQ29616201
Knockdown of FoxP2 alters spine density in Area X of the zebra finch.Q30010959
Aberrant striatal functional connectivity in children with autismQ30467954
MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformationsQ33766816
VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamateQ34315492
Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complexQ34341154
Cocaine regulates MEF2 to control synaptic and behavioral plasticityQ34818266
Ectopic expression of nolz-1 in neural progenitors promotes cell cycle exit/premature neuronal differentiation accompanying with abnormal apoptosis in the developing mouse telencephalonQ35000746
Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartmentsQ35208420
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilitiesQ35765423
Monosynaptic cortical input and local axon collaterals of identified striatonigral neurons. A light and electron microscopic study using the golgi-peroxidase transport-degeneration procedureQ36589530
Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism riskQ36886944
Speech and Language Impairments in Autism: Insights from Behavior and NeuroimagingQ37389766
Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identityQ37474815
Decoding the genetics of speech and languageQ38066309
Activity-dependent neuronal signalling and autism spectrum disorderQ38074584
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)1513-1522
P577publication date2016-09-05
P1433published inNature NeuroscienceQ1535359
P1476titleFoxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c
P478volume19

Reverse relations

cites work (P2860)
Q58568494Active intermixing of indirect and direct neurons builds the striatal mosaic
Q58122132Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs
Q57797154Altered social behavior in mice carrying a cortical Foxp2 deletion
Q64113209Beyond Critical Period Learning: Striatal FoxP2 Affects the Active Maintenance of Learned Vocalizations in Adulthood
Q47950665Brain correlates of constituent structure in sign language comprehension
Q42743849CD8 T cells contribute to lacrimal gland pathology in the nonobese diabetic mouse model of Sjögren syndrome
Q91855017Chromatin Decondensation by FOXP2 Promotes Human Neuron Maturation and Expression of Neurodevelopmental Disease Genes
Q90372839Dynamic FoxP2 levels in male zebra finches are linked to morphology of adult-born Area X medium spiny neurons
Q83232400FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
Q64083815Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release
Q64083825Foxp2 regulates anatomical features that may be relevant for vocal behaviors and bipedal locomotion
Q90442613Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment
Q64097689Humanising the mouse genome piece by piece
Q39005713Layer-specific chromatin accessibility landscapes reveal regulatory networks in adult mouse visual cortex.
Q64120396MEF-2 isoforms' (A-D) roles in development and tumorigenesis
Q47661198Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors
Q95840004Nectin-2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula
Q90597210Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity
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Q59355730Stereotaxic Surgery for Genetic Manipulation in Striatal Cells of Neonatal Mouse Brains
Q92089986Synaptic Wiring of Corticostriatal Circuits in Basal Ganglia: Insights into the Pathogenesis of Neuropsychiatric Disorders
Q42031176Talking Convergence: Growing Evidence Links FOXP2 and Retinoic Acid in Shaping Speech-Related Motor Circuitry
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Q58772354is essential for normal mushroom body and wing development

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