Activity-dependent neuronal signalling and autism spectrum disorder

scientific article published on January 2013

Activity-dependent neuronal signalling and autism spectrum disorder is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/NATURE11860
P932PMC publication ID3576027
P698PubMed publication ID23325215

P2093author name stringMichael E Greenberg
Daniel H Ebert
P2860cites workMutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.Q48354837
Stimulation of neuronal acetylcholine receptors induces rapid gene transcriptionQ69602070
Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactinQ22010466
Advances in autism genetics: on the threshold of a new neurobiologyQ22251023
Neuroligins and neurexins link synaptic function to cognitive diseaseQ22251092
Correction of fragile X syndrome in mice.Q22251255
The Autistic Neuron: Troubled Translation?Q22252314
Postnatal development of the visual cortex and the influence of environmentQ22337285
LTP and LTDQ22337342
SHANK1 Deletions in Males with Autism Spectrum DisorderQ24313471
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairmentsQ24328996
Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor functionQ24338263
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndromeQ24530286
Altered synaptic plasticity in a mouse model of fragile X mental retardationQ24530695
Functional impact of global rare copy number variation in autism spectrum disordersQ24596191
Shank3 mutant mice display autistic-like behaviours and striatal dysfunctionQ24597501
SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1Q24618070
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in miceQ24629938
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autismQ24631425
Rate of de novo mutations and the importance of father's age to disease riskQ24632353
Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosisQ24648897
Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous systemQ24650727
Identifying autism loci and genes by tracing recent shared ancestryQ24655308
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2Q26269865
Synaptic cell adhesionQ26269885
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampusQ26269889
The pathophysiology of fragile X (and what it teaches us about synapses)Q27010675
CNVs: harbingers of a rare variant revolution in psychiatric geneticsQ27022289
Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autismQ28117072
The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapsesQ28208647
Translational control by MAPK signaling in long-term synaptic plasticity and memoryQ28249953
Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)Q28252295
Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depressionQ28257629
Patterns and rates of exonic de novo mutations in autism spectrum disordersQ28264242
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2Q28268807
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse numberQ28297899
Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndromeQ28505346
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and functionQ28507026
MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse numberQ28507266
Activity-dependent regulation of inhibitory synapse development by Npas4Q28510423
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTDQ28585633
High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autismQ28730279
Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neuronsQ28748325
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2Q28941210
Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with AutismQ29013643
De novo mutations revealed by whole-exome sequencing are strongly associated with autismQ29547269
The molecular biology of memory storage: a dialogue between genes and synapsesQ29547845
Widespread transcription at neuronal activity-regulated enhancersQ29614330
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutationsQ29614573
The mGluR theory of fragile X mental retardationQ29615060
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturationQ29616327
Reversal of neurological defects in a mouse model of Rett syndromeQ29616452
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome systemQ29617400
Regulation of dendritic spine morphology and synaptic function by Shank and HomerQ30014842
Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndromeQ30529349
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.Q33744301
A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticityQ34062918
MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulantsQ34086410
Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathwayQ34094970
Whole-exome sequencing and homozygosity analysis implicate depolarization-regulated neuronal genes in autismQ34236650
Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathwaysQ34334761
Synaptic protein degradation underlies destabilization of retrieved fear memoryQ34747479
Cocaine regulates MEF2 to control synaptic and behavioral plasticityQ34818266
Experience-dependent retinogeniculate synapse remodeling is abnormal in MeCP2-deficient miceQ34856164
A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibitionQ34889693
Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signalingQ35047447
Neurexin-neuroligin transsynaptic interaction mediates learning-related synaptic remodeling and long-term facilitation in aplysiaQ35104642
Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.Q35114553
Mutations causing syndromic autism define an axis of synaptic pathophysiologyQ35587150
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.Q35629499
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilitiesQ35765423
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.Q35949697
Maternal loss of Ube3a produces an excitatory/inhibitory imbalance through neuron type-specific synaptic defects.Q36025486
CACNA1C (Cav1.2) in the pathophysiology of psychiatric diseaseQ36281961
Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals.Q36752504
The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channelsQ36883128
Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rateQ36966248
Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selectionQ37070840
Communication between the synapse and the nucleus in neuronal development, plasticity, and diseaseQ37212202
From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and functionQ37279404
Ube3a is required for experience-dependent maturation of the neocortex.Q37340937
The conundrums of understanding genetic risks for autism spectrum disordersQ37613535
Deconstruction for reconstruction: the role of proteolysis in neural plasticity and diseaseQ37827231
TSC1/TSC2 signaling in the CNS.Q37844199
The postsynaptic organization of synapsesQ37951923
PTEN signaling in autism spectrum disordersQ38015944
Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and functionQ39461991
Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2.Q40372504
Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memoryQ40888422
Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice.Q41844282
Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndromeQ41849184
Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic functionQ42049245
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).Q42184021
RETRACTED: Imaging Activity-Dependent Regulation of Neurexin-Neuroligin Interactions Using trans-Synaptic Enzymatic BiotinylationQ42393682
A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communicationQ43615606
Phosphorylation influences the translation state of FMRP-associated polyribosomesQ44626609
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.Q46832201
Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation.Q48294933
P433issue7432
P407language of work or nameEnglishQ1860
P921main subjectautismQ38404
autism spectrum disorderQ1436063
P304page(s)327-337
P577publication date2013-01-01
P1433published inNatureQ180445
P1476titleActivity-dependent neuronal signalling and autism spectrum disorder
P478volume493

Reverse relations

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Q57287964Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors
Q41711335Sequential chromatin immunoprecipitation to detect SUMOylated MeCP2 in neurons
Q59794119Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice
Q47683497Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression
Q37625439Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model
Q30578795Spatially selective photoconductive stimulation of live neurons
Q42006907Stream-dependent development of higher visual cortical areas
Q55261718Structural insights and characterization of human Npas4 protein.
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Q90195652Synaptic Dysfunction in Human Neurons With Autism-Associated Deletions in PTCHD1-AS
Q43070343Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4.
Q35080413Synaptic synthesis, dephosphorylation, and degradation: a novel paradigm for an activity-dependent neuronal control of CDKL5
Q39451309Synaptically localized transcriptional regulators in memory formation
Q36424672Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Q88644760TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration
Q27023257Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes
Q89998822Tau Reduction Prevents Key Features of Autism in Mouse Models
Q89207617The ASD Living Biology: from cell proliferation to clinical phenotype
Q47364339The Autism Protein Ube3A/E6AP Remodels Neuronal Dendritic Arborization via Caspase-Dependent Microtubule Destabilization.
Q92294352The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression
Q47739190The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A.
Q92862300The Ras Superfamily of Small GTPases in Non-neoplastic Cerebral Diseases
Q26774448The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia
Q28572147The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines
Q49062199The bed nucleus of the stria terminalis has developmental and adult forms in mice, with the male bias in the developmental form being dependent on testicular AMH.
Q26998540The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome
Q30586703The effects of aging on the BTBR mouse model of autism spectrum disorder
Q40859955The landscape of copy number variations in Finnish families with autism spectrum disorders
Q38259907The relevance of human fetal subplate zone for developmental neuropathology of neuronal migration disorders and cortical dysplasia
Q34437682The social brain network and autism
Q37598422The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders
Q36084776Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration
Q30655543Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation
Q56860951Transcriptional Regulation by MECP2
Q42776718Transcriptome analysis revealed impaired cAMP responsiveness in PHF21A-deficient human cells
Q54961637Uncovering True Cellular Phenotypes: Using Induced Pluripotent Stem Cell-Derived Neurons to Study Early Insults in Neurodevelopmental Disorders.
Q38777978Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops
Q38956328Variants of the CNTNAP2 5' promoter as risk factors for autism spectrum disorders: a genetic and functional approach
Q97531129Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice
Q99555072Visual Sequences Drive Experience-Dependent Plasticity in Mouse Anterior Cingulate Cortex
Q27306360Visual circuit development requires patterned activity mediated by retinal acetylcholine receptors
Q39010870Yin-yang actions of histone methylation regulatory complexes in the brain
Q90675178hsa-let-7c miRNA Regulates Synaptic and Neuronal Function in Human Neurons
Q50074763α-Actinin Anchors PSD-95 at Postsynaptic Sites.

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