IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

scientific article published on 11 May 2008

IL-21 and TGF-beta are required for differentiation of human T(H)17 cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1026439887
P356DOI10.1038/NATURE07021
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/nature07021
P932PMC publication ID2760130
P698PubMed publication ID18469800
P5875ResearchGate publication ID5381348

P50authorDavid A. HaflerQ25004567
Vijay KuchrooQ87889159
P2093author name stringLi Yang
David E Anderson
Estelle Bettelli
Mohamed Oukka
Clare Baecher-Allan
William D Hastings
P2860cites workIL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent mannerQ24644925
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammationQ28266133
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cellsQ28296956
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gammaQ28506783
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysQ29614839
Essential autocrine regulation by IL-21 in the generation of inflammatory T cellsQ29616147
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cellsQ29616148
Development, cytokine profile and function of human interleukin 17-producing helper T cellsQ29617131
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cellsQ29618163
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyQ34712326
Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.Q36089312
T(H)-17 differentiation: of mice and menQ80826320
P433issue7202
P407language of work or nameEnglishQ1860
P304page(s)350-352
P577publication date2008-05-11
P1433published inNatureQ180445
P1476titleIL-21 and TGF-beta are required for differentiation of human T(H)17 cells
P478volume454

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Q37330081Norepinephrine and adenosine-5'-triphosphate synergize in inducing IL-6 production by human dermal microvascular endothelial cells
Q47764326Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease
Q46089932Novel therapeutic targets along the Th17 pathway
Q43296795Obesity predisposes to Th17 bias
Q53068101Oestrogen up-regulates interleukin-21 production by CD4(+) T lymphocytes in patients with systemic lupus erythematosus.
Q37635735Of mice and men: how animal models advance our understanding of T-cell function in RA.
Q34027620Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance
Q45899456Optimization of human Th17 cell differentiation in vitro: evaluating different polarizing factors.
Q50959906Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
Q39434888Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases
Q37419035Pathophysiology of multiple sclerosis
Q36395586Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques
Q35915482Pentraxin 3(PTX 3): an endogenous modulator of the inflammatory response
Q84233203Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis
Q34983123Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
Q36346324Phenotypes of Peripheral Blood Lymphocytes and Cytokine Expression in Polymyositis and Dermatomyositis before Treatment and after Clinical Remission
Q38310232Plasticity of human CD4 T cell subsets
Q34376236Positive and Negative Regulation of Th17 Cell Differentiation: Evaluating The Impact of RORC2.
Q54355713Possible involvement of IL-21 and IL-10 on salivary IgA levels in chronic periodontitis subjects.
Q48312123Possible involvement of chemokine C-C receptor 7- programmed cell death-1+ follicular helper T-cell subset in the pathogenesis of autoimmune hepatitis.
Q34424965Potentiation of Th17 cytokines in aging process contributes to the development of colitis
Q92075986Presence, function, and regulation of IL-17F-expressing human CD4+ T cells
Q33986006Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation
Q35633994Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment.
Q45939390Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
Q46041262Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells
Q92434479Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment
Q27026785Putting together the psoriasis puzzle: an update on developing targeted therapies
Q36847004RORC2 Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis
Q36610596RORC2 gene silencing in human Th17 cells by siRNA: design and evaluation of highly efficient siRNA.
Q45981618RORC2: the master of human Th17 cell programming.
Q34831560RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells
Q37164554Rapid myeloid cell transcriptional and proteomic responses to periodontopathogenic Porphyromonas gingivalis
Q24626339Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells
Q37864851Recovery of the immune balance between Th17 and regulatory T cells as a treatment for systemic lupus erythematosus
Q36106307Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management
Q33608731Regulating human Th17 cells via differential expression of IL-1 receptor
Q35154002Regulation and function of IL-17A- and IL-22-producing γδ T cells.
Q37348457Regulation and function of proinflammatory TH17 cells
Q26799975Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs
Q37915047Regulation of Th17 cell differentiation by intestinal commensal bacteria
Q34953484Regulation of human Th9 differentiation by type I interferons and IL-21
Q26830939Regulation of human helper T cell subset differentiation by cytokines
Q37374938Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans
Q37062815Regulation of pathogenic Th17 cell differentiation by IL-10 in the development of glomerulonephritis
Q39097028Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection
Q37900645Regulatory T cells and IL-17-producing cells in graft-versus-host disease
Q36278700Regulatory T cells and Th17 cells in viral infections: implications for multiple sclerosis and myocarditis
Q37338455Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development
Q37607071Regulatory T cells as therapeutic targets in rheumatoid arthritis
Q37468253Regulatory T cells modulate Th17 responses in patients with positive tuberculin skin test results
Q37021703Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive?
Q35111378Relationship of CD146 expression to secretion of interleukin (IL)-17, IL-22 and interferon-γ by CD4(+) T cells in patients with inflammatory arthritis
Q40129656Report on the 1st scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Mittenwalde/Motzen, Germany, Oct. 30th - Nov. 1st, 2009.
Q34976906Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism
Q37315484Rheumatoid arthritis: a view of the current genetic landscape
Q40109555Role of CD4 T cell helper subsets in immune response and deviation of CD8 T cells in mice
Q36795816Role of TH-17 cells in rheumatic and other autoimmune diseases
Q26860784Role of TH17 cytokines in the control of colorectal cancer
Q38237647Role of Th17 Cells in the Pathogenesis of Human IBD.
Q37622866Role of Th17 cells and IL-17 in lung transplant rejection
Q35767856Role of endometrial immune cells in implantation
Q51690338Role of podoplanin in the high interleukin-17A secretion resulting from interactions between activated lymphocytes and psoriatic skin-derived mesenchymal cells.
Q43279110Selected commensal-related bacteria and Toll-like receptor 3 agonist combinatorial codes synergistically induce interleukin-12 production by dendritic cells to trigger a T helper type 1 polarizing programme.
Q44237691Serum IL-17 and IL-23 levels and autoantigen-specific Th17 cells are elevated in patients with ANCA-associated vasculitis
Q57594184Short-Chain Fatty Acids Regulate Cytokines and Th17/Treg Cells in Human Peripheral Blood Mononuclear Cellsin vitro
Q37367853Signal transduction and Th17 cell differentiation
Q35238480Signal transduction pathways and transcriptional regulation in Th17 cell differentiation
Q34986405Signalling through C-type lectin receptors: shaping immune responses
Q58326709Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis
Q90781384Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
Q34331407Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
Q35193745Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells
Q37851349State of the union between metabolism and the immune system in type 2 diabetes.
Q27670714Structural Basis of Digoxin That Antagonizes ROR t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production
Q37164125Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications.
Q37316528Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis
Q26823613T Cells: Soldiers and Spies--The Surveillance and Control of Effector T Cells by Regulatory T Cells
Q92634783T Helper 9 Cells: A New Player in Immune-Related Diseases
Q89860707T Helper Cells: The Modulators of Inflammation in Multiple Sclerosis
Q28081582T Helper Lymphocyte Subsets and Plasticity in Autoimmunity and Cancer: An Overview
Q41881121T cell unresponsiveness in a pediatric cystic fibrosis patient: a case report
Q37777431T cells in multiple sclerosis and experimental autoimmune encephalomyelitis.
Q38079816T cells out of control--impaired immune regulation in the inflamed joint
Q36973651T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation
Q34702070T follicular helper cells mediate expansion of regulatory B cells via IL-21 in Lupus-prone MRL/lpr mice
Q24609737T helper 17 cell heterogeneity and pathogenicity in autoimmune disease
Q38162223T helper 17 cells in autoimmune liver diseases
Q37669790T helper 17 cells: discovery, function, and physiological trigger
Q34939023T helper cytokine patterns: defined subsets, random expression, and external modulation
Q34180508T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice
Q35623903T(H)17 cells in tumour immunity and immunotherapy.
Q34691040T-cell growth, cell surface organization, and the galectin-glycoprotein lattice
Q35220895TAM receptor knockout mice are susceptible to retinal autoimmune induction
Q37316137TGF-beta can leave you breathless
Q64900222TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells.
Q34113303TGF-beta induces IL-9 production from human Th17 cells.
Q37528532TGF-β Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner
Q39094862TGF-β regulation of encephalitogenic and regulatory T cells in multiple sclerosis
Q28275410TGFβ signalling in context
Q36955309TH-17 cells in rheumatoid arthritis
Q38016854TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
Q37467739TH17 cells and regulatory T cells in primary immunodeficiency diseases
Q38007258TH17 deficiency in human disease
Q34997144TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines
Q27026324Targeting of interleukin-17 in the treatment of psoriasis
Q33894387Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity
Q51961643Th memory for interleukin-17 expression is stable in vivo.
Q83011878Th-17 associated cytokines in patients with reactive arthritis/undifferentiated spondyloarthropathy
Q64092917Th17 and Th1 Lymphocytes in Oligoarticular Juvenile Idiopathic Arthritis
Q37989545Th17 and regulatory T cells in women with recurrent pregnancy loss
Q34395054Th17 and regulatory T cells: implications for AIDS pathogenesis
Q87056606Th17 cell expansion in gastric cancer may contribute to cancer development and metastasis
Q37845414Th17 cell, the new player of neuroinflammatory process in multiple sclerosis.
Q84983013Th17 cells and human arthritic diseases
Q35051685Th17 cells and interleukin-17 increase with poor prognosis in patients with acute myeloid leukemia
Q33838915Th17 cells and regulatory T cells in elite control over HIV and SIV.
Q21284677Th17 cells in autoimmune and infectious diseases
Q38181087Th17 cells in immunity and autoimmunity.
Q37173921Th17 cells: from precursors to players in inflammation and infection
Q36698010Th17 cytokines induce pro-fibrotic cytokines release from human eosinophils
Q26775934Th17 plasticity and its changes associated with inflammatory bowel disease
Q90661480Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis
Q40110959Th17 response and inflammatory autoimmune diseases
Q37456949Th17-associated cytokines as a therapeutic target for steroid-insensitive asthma
Q27023029Th22 cells in allergic disease
Q37989164The IL-23/IL-17 pathway in inflammatory bowel disease
Q34969188The IL-23/Th17 axis in the immunopathogenesis of psoriasis
Q50175862The Interleukin (IL)-23/T helper (Th)17 Axis in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.
Q37393703The T(reg)/Th17 cell balance: a new paradigm for autoimmunity
Q47141013The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis
Q36713721The Th17 family: flexibility follows function.
Q38101877The Th17 pathway as a therapeutic target in rheumatoid arthritis and other autoimmune and inflammatory disorders.
Q50949116The Wnt inhibitor secreted Frizzled-Related Protein 1 (sFRP1) promotes human Th17 differentiation.
Q34532223The adjuvant double mutant Escherichia coli heat labile toxin enhances IL-17A production in human T cells specific for bacterial vaccine antigens
Q37516563The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases
Q64235398The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch-Schonlein purpura: A PRISMA-compliant meta-analysis
Q31096343The changes of Th17 cells and the related cytokines in the progression of human colorectal cancers
Q37728840The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease
Q61840854The deregulation of regulatory T cells on interleukin-17-producing T helper cells in patients with unexplained early recurrent miscarriage
Q56607716The dual nature of TH17 cells: shifting the focus to function
Q35294513The dysregulation of cytokine networks in systemic lupus erythematosus
Q36959641The effect of diabetes-associated autoantigens on cell processes in human PBMCs and their relevance to autoimmune diabetes development
Q37290719The effects of IL-6 on CD4 T cell responses
Q47157832The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model.
Q24623195The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings
Q38618889The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells.
Q21131158The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome
Q37682484The immunology of fibrosis: innate and adaptive responses
Q38164343The immunomodulatory effect of probiotics beyond atopy: an update
Q44074186The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.
Q41551980The inducible costimulator augments Tc17 cell responses to self and tumor tissue.
Q33808773The loss of CCR6+ and CD161+ CD4+ T-cell homeostasis contributes to disease progression in SIV-infected rhesus macaques
Q35596984The many faces of Th17 cells
Q35591962The microbiome in infectious disease and inflammation
Q38181085The multifaceted role of Th17 lymphocytes and their associated cytokines in cancer
Q37377446The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
Q38984914The obesity-related pathology and Th17 cells.
Q27005951The outliers become a stampede as immunometabolism reaches a tipping point
Q33354622The periprosthetic capsule and connective tissue diseases: a piece in the puzzle of autoimmune/autoinflammatory syndrome induced by adjuvants
Q37280352The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation.
Q37528094The plasticity of human Treg and Th17 cells and its role in autoimmunity
Q37902959The potential role of interleukin-17 in severe asthma
Q45835190The prevalence of Th17 cells and FOXP3 regulate T cells (Treg) in children with primary nephrotic syndrome
Q34196541The regulatory effect of liuwei dihuang pills on cytokines in mice with experimental autoimmune encephalomyelitis
Q24648939The role of NKT cells in tumor immunity
Q37598359The role of T helper type 17 cells in inflammatory arthritis
Q48179424The role of T-helper 17 (Th17) cells in patients with medulloblastoma
Q52570914The role of TGF-β in Th17 differentiation.
Q38565395The role of Th17 and Treg responses in the pathogenesis of RSV infection.
Q37831821The role of Th17 lymphocytes in the autoimmune and chronic inflammatory diseases
Q37812002The role of cytokines in Guillain-Barré syndrome
Q38238738The role of interleukin 17 in tumour proliferation, angiogenesis, and metastasis.
Q36085086The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases
Q46007942The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells.
Q38473746The skewed balance between Tregs and Th17 in chronic lymphocytic leukemia.
Q28118511The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
Q39015080Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders.
Q36490256Therapeutic targeting of the inflammome
Q51018464Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients.
Q24616336Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation
Q38123463Transcription factor interplay in T helper cell differentiation
Q37425866Transcriptional regulatory networks in Th17 cell differentiation
Q44117426Transforming growth factor (TGF)-β signalling is increased in rheumatoid synovium but TGF-β blockade does not modify experimental arthritis
Q37402405Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation
Q37632472Translational mini-review series on Th17 cells: CD4 T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulation
Q37632469Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells.
Q35012792Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease.
Q36974002Tregs are regulated by cytokines: implications for autoimmunity
Q36057492Trial Watch: Immunostimulatory cytokines
Q30882988Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis
Q37478061Type 17 T helper cells-origins, features and possible roles in rheumatic disease
Q41863506Upregulated IL-21 and IL-21 receptor expression is involved in experimental autoimmune uveitis (EAU).
Q24596756Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis: a primer
Q27009990Utilizing regulatory T cells against rheumatoid arthritis
Q50653450Vitamin D improves cognitive function and modulates Th17/T reg cell balance after hepatectomy in mice.
Q35604631cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus
Q34378756gp130 at the nexus of inflammation, autoimmunity, and cancer
Q40326814miR-27a and miR-214 exert opposite regulatory roles in Th17 differentiation via mediating different signaling pathways in peripheral blood CD4+ T lymphocytes of patients with relapsing-remitting multiple sclerosis.

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