Lyn mitigates mouse airway remodeling by downregulating the TGF-β3 isoform in house dust mite models

scientific article published on 14 October 2013

Lyn mitigates mouse airway remodeling by downregulating the TGF-β3 isoform in house dust mite models is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.1301596
P932PMC publication ID3863691
P698PubMed publication ID24127553
P5875ResearchGate publication ID257815223

P50authorGeorge F. GaoQ16260071
P2093author name stringJohn Fox
Jun Liu
Min Wu
Zhigang Liu
Guoping Li
Yang Jin
Hongwei Gao
P2860cites workAspirin and salicylates inhibit the IL-4- and IL-13-induced activation of STAT6Q28192195
Pitrakinra, a dual IL-4/IL-13 antagonist for the potential treatment of asthma and eczemaQ28301047
Fine tuning inflammation at the front door: macrophage complement receptor 3-mediates phagocytosis and immune suppression for Francisella tularensisQ28485277
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Chronic respiratory aeroallergen exposure in mice induces epithelial-mesenchymal transition in the large airwaysQ33809320
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Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25.Q34032848
Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type miceQ34199837
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Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediatesQ35011464
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Expression and activation of TGF-beta isoforms in acute allergen-induced remodelling in asthmaQ35844179
A novel co-operative mechanism linking TGFβ and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cellsQ36071873
Airway remodeling in asthmaQ84509468
Transforming growth factor-β₁-induced expression of connective tissue growth factor is enhanced in bronchial fibroblasts derived from asthmatic patientsQ84590250
Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthmaQ36084871
Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway diseaseQ36145788
Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor alpha in a murine model of allergic asthmaQ36207811
The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthmaQ36357991
The regulatory role of TGF-beta in airway remodeling in asthmaQ36746333
Combined sensitization of mice to extracts of dust mite, ragweed, and Aspergillus species breaks through tolerance and establishes chronic features of asthmaQ37196833
Effect of proinflammatory cytokines on the human MUC5AC promoter activity in vitro and in vivo.Q37236638
Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease.Q37308018
CREB mediates prostaglandin F2alpha-induced MUC5AC overexpression.Q37373688
Cystic fibrosis mice lacking Muc1 have reduced amounts of intestinal mucusQ37387923
Role of transforming growth factor-β in airway remodeling in asthmaQ37762920
Airway remodeling in asthma: new mechanisms and potential for pharmacological interventionQ37844892
Epithelial-mesenchymal transition in the pathophysiology of airway remodelling in asthmaQ37973155
A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation.Q38323076
Inhibition of signal transducer and activator of transcription 1 attenuates allergen-induced airway inflammation and hyperreactivity.Q38337599
Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation.Q38356658
Chemoattractant-Induced Signaling via the Ras–ERK and PI3K–Akt Networks, along with Leukotriene C4 Release, Is Dependent on the Tyrosine Kinase Lyn in IL-5– and IL-3–Primed Human Blood EosinophilsQ39627809
Inhaled vs subcutaneous effects of a dual IL-4/IL-13 antagonist in a monkey model of asthmaQ39792840
Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signalingQ40098558
Growth factor expression during rat development: a comparison of TGF-beta 3, TGF-alpha, bFGF, PDGF and PDGF-RQ41163058
Characterization of recombinant soluble human transforming growth factor-β receptor Type II (rhTGF-βsRII)Q41331826
Differential regulation of chemokine expression by Th1 and Th2 cytokines and mechanisms of eotaxin/CCL-11 expression in human airway smooth muscle cellsQ42045927
Regulation of collagen synthesis in mouse skin fibroblasts by distinct angiotensin II receptor subtypes.Q42451291
Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting SmadsQ42455495
P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathwayQ43063790
Continuous supply of TGFβ3 via adenoviral vector promotes type I collagen and viability of fibroblasts in alginate hydrogel.Q43142013
Increased TGF-beta2 in severe asthma with eosinophiliaQ45215090
Lyn-dependent signaling regulates the innate immune response by controlling dendritic cell activation of NK cells.Q45306987
Cholesterol-rich membrane rafts and Lyn are involved in phagocytosis during Pseudomonas aeruginosa infectionQ46771570
House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epitheliumQ47996385
The outer wall of small airways is a major site of remodeling in fatal asthmaQ48019489
DNA vaccine encoding Der p 2 allergen generates immunologic protection in recombinant Der p 2 allergen-induced allergic airway inflammation mice model.Q50485285
New asthma biomarkers: lessons from murine models of acute and chronic asthma.Q53436713
Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling.Q53507300
Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and function.Q53571819
TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical studyQ71078177
Mechanism of inhibition of eosinophil activation by transforming growth factor-beta. Inhibition of Lyn, MAP, Jak2 kinases and STAT1 nuclear factorQ71829512
A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammationQ80234375
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studiesQ81471173
Airway fibroblasts exhibit a synthetic phenotype in severe asthmaQ81490812
Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathwayQ81672236
Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient miceQ84263094
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectDermatophagoides pteronyssinusQ4573411
P304page(s)5359-5370
P577publication date2013-10-14
P1433published inJournal of ImmunologyQ3521441
P1476titleLyn mitigates mouse airway remodeling by downregulating the TGF-β3 isoform in house dust mite models
P478volume191

Reverse relations

cites work (P2860)
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Q57752587Lyn prevents aberrant inflammatory responses to infection in mammalian systems by repressing a SHIP-1-associated signaling cluster
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Q37644427Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation
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Q90686961TRPC1 intensifies house dust mite-induced airway remodeling by facilitating epithelial-to-mesenchymal transition and STAT3/NF-κB signaling
Q99350038Transcriptional analysis of cleft palate in TGFβ3 mutant mice
Q44773384Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunity

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