The regulatory role of TGF-beta in airway remodeling in asthma

scientific article published on 27 February 2007

The regulatory role of TGF-beta in airway remodeling in asthma is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1018118290
P356DOI10.1038/SJ.ICB.7100044
P698PubMed publication ID17325694
P5875ResearchGate publication ID6480199

P2093author name stringDevendra K Agrawal
Richard F Murphy
Toluwalope Makinde
P2860cites workSmad7 inhibits the survival nuclear factor kappaB and potentiates apoptosis in epithelial cellsQ73787709
TGF-beta1 stimulates IL-8 release, COX-2 expression, and PGE(2) release in human airway smooth muscle cellsQ73992910
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T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthmaQ28201095
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Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodelingQ28278918
Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthmaQ28371074
SMAD2 and SMAD7 involvement in the post-translational regulation of Muc4 via the transforming growth factor-beta and interferon-gamma pathways in rat mammary epithelial cellsQ28572073
Transforming growth factor-beta stimulates vascular endothelial growth factor production by folliculostellate pituitary cellsQ28577476
Epithelial expression of profibrotic mediators in a model of allergen-induced airway remodelingQ31131992
Tissue fibrocytes in patients with mild asthma: a possible link to thickness of reticular basement membrane?Q33237943
Airway smooth muscle in health and disease; methods of measurement and relation to functionQ33898734
Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosisQ33913785
Tissue remodeling as a feature of persistent asthmaQ33944433
Consequences of long-term inflammation. Airway remodelingQ33977282
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Anti-fibrotic effects of theophylline on lung fibroblastsQ34487182
A role for eosinophils in airway remodelling in asthmaQ34550355
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Human bronchial fibroblasts express the 5-lipoxygenase pathwayQ34997664
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Provocation with adenosine 5'-monophosphate increases sputum eosinophilsQ35082517
Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma.Q35103250
Transforming growth factor-beta and its role in asthmaQ35172753
Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?Q35173450
Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthmaQ35537590
Cytoskeletal remodeling of the airway smooth muscle cell: a mechanism for adaptation to mechanical forces in the lung.Q35546483
Mechanisms of inflammation-mediated airway smooth muscle plasticity and airways remodeling in asthmaQ35546498
Airway smooth muscle: immunomodulatory cells that modulate airway remodeling?Q35546519
Airway smooth muscle—its relationship to the extracellular matrixQ35546536
Is airway remodeling clinically relevant in asthma?Q35600683
Matrix metalloproteinases in the pathogenesis of asthma and COPD: implications for therapyQ35790735
New advances and potential therapies for the treatment of asthmaQ35831532
Proliferative aspects of airway smooth muscle.Q35862082
Integrins in pulmonary inflammatory diseasesQ36074580
Remodeling in asthma and chronic obstructive pulmonary diseaseQ36518612
Following the TRAIL to apoptosisQ36685559
Regional fibroblast heterogeneity in the lung: implications for remodelingQ37144492
C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblastsQ38354405
Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signalingQ38358454
Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathwaysQ38362663
TGF-beta 1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signalingQ40320864
Smad3 mediates TGF-beta1-induced collagen gel contraction by human lung fibroblastsQ40349505
Adhesion and Rac1-dependent regulation of biglycan gene expression by transforming growth factor-beta. Evidence for oxidative signaling through NADPH oxidaseQ40392011
Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts.Q40475650
Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-betaQ40491323
Differential regulation of VEGF by TGF-beta and hypoxia in rat proximal tubular cells.Q40547600
Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.Q40854145
Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathwayQ40874515
Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cellsQ40998147
Differential proliferation of fibroblasts cultured from normal and fibrotic human lungsQ41407410
Molecular mechanisms of blood vessel formationQ41560712
Lung mucus: a clinician's viewQ41578733
Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting SmadsQ42455495
Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lungQ42484306
Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1-induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNK.Q42808748
Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblastsQ43550271
Release of biologically active TGF-beta from airway smooth muscle cells induces autocrine synthesis of collagenQ43566987
Angiogenesis and Remodeling of Airway Vasculature in Chronic InflammationQ43816379
Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cellsQ44078618
In vitro wounding of airway smooth muscle cell monolayers increases expression of TGF-beta receptorsQ44123079
Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids.Q44212468
Transforming growth factor-beta1 potentiates renal tubular epithelial cell death by a mechanism independent of Smad signalingQ44298458
TH2 Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroidsQ44467287
beta1-Integrins mediate enhancement of airway smooth muscle proliferation by collagen and fibronectinQ45122173
Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependentQ45204444
Corticosteroids prevent myofibroblast accumulation and airway remodeling in miceQ46572428
Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrixQ46650411
Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathwayQ46716847
Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferationQ46913829
Mucus hypersecretion: a common symptom, a common mechanism?Q47287332
Transforming growth factor-beta1 stimulates vascular endothelial growth factor 164 via mitogen-activated protein kinase kinase 3-p38alpha and p38delta mitogen-activated protein kinase-dependent pathway in murine mesangial cellsQ47605539
Smad and p38-MAPK signaling mediates apoptotic effects of transforming growth factor-beta1 in human airway epithelial cellsQ47633801
TGF-beta potentiates airway smooth muscle responsiveness to bradykininQ47789319
Airway remodeling: therapeutic target or not?Q47826304
Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma.Q47979573
Release of biologically active TGF-beta1 by alveolar epithelial cells results in pulmonary fibrosisQ51685121
TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cellsQ51714404
The expression of transforming growth factor-beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinomaQ52141308
Transcription factors T-bet and GATA-3 regulate development of airway remodelingQ53001969
Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthmaQ53598437
Regulation of TGF-β1-induced connective tissue growth factor expression in airway smooth muscle cellsQ62889952
Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-beta-induced expression of connective tissue growth factor in human fibroblastsQ64378592
Myofibroblasts and subepithelial fibrosis in bronchial asthmaQ68576490
The mechanics of airway narrowing in asthmaQ69938618
Bronchial elastic fibers in normal subjects and asthmatic patientsQ71078897
Human airway narrowing measured using high resolution computed tomographyQ71767484
Inhibition of myofibroblast apoptosis by transforming growth factor beta(1)Q73205575
The airway longitudinal elastic fiber network and mucosal folding in patients with asthmaQ73321383
Transforming growth Factor-beta1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathwayQ73513180
Bronchial Subepithelial Fibrosis Correlates With Airway Responsiveness to MethacholineQ73521531
[Airway remodeling in asthma: mechanisms and therapeutic perspectives]Q73596873
Transforming Growth Factor- β Expression in Mucosal Biopsies in Asthma and Chronic BronchitisQ73651422
Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluidQ73651471
Eosinophil-associated TGF- β1mRNA Expression and Airways Fibrosis in Bronchial AsthmaQ73728083
P433issue5
P921main subjectasthmaQ35869
P304page(s)348-356
P577publication date2007-02-27
P13046publication type of scholarly workreview articleQ7318358
P1433published inImmunology & Cell BiologyQ13731918
P1476titleThe regulatory role of TGF-beta in airway remodeling in asthma
P478volume85

Reverse relations

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