Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways

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Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M206535200
P698PubMed publication ID12270924

P50authorSuvi-Katri LeivonenQ42808707
P2093author name stringJiahuai Han
Andrew Chantry
Lari Hakkinen
Veli-Matti Kahari
P2860cites workSmad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcriptionQ24311810
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Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteinsQ24652300
Smads bind directly to the Jun family of AP-1 transcription factorsQ24685193
Matrix metalloproteinases in tumor invasionQ28144147
???Q28140333
Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13)Q28236176
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signallingQ28251743
Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cellsQ28263599
Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor betaQ28608955
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signalingQ28631440
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 geneQ29616540
Transcriptional control by the TGF-beta/Smad signaling systemQ29618985
How matrix metalloproteinases regulate cell behaviorQ29620360
Smads as transcriptional co-modulatorsQ33860520
TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathwayQ33890533
Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3.Q33916695
Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilizationQ34132949
Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase familyQ34453631
Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulationQ34527773
Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vectorQ35068584
Smad2 transduces common signals from receptor serine-threonine and tyrosine kinasesQ35201617
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic familyQ36136925
SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.Q36754616
Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor betaQ38304876
Smad-dependent transcriptional activation of human type VII collagen gene (COL7A1) promoter by transforming growth factor-betaQ38337315
Regulation of clusterin gene expression by transforming growth factor betaQ38342490
Human pro alpha 1(I) collagen: cDNA sequence for the C-propeptide domainQ40536480
Cross-talk between the p42/p44 MAP kinase and Smad pathways in transforming growth factor beta 1-induced furin gene transactivationQ40793124
Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cellsQ40817472
Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.Q40854145
Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.Q40870310
Regulation of Smad7 promoter by direct association with Smad3 and Smad4.Q40918176
TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signalingQ41083690
Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activationQ41616341
Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-beta in fibroblasts and keratinocytes.Q42517711
Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinaseQ42631549
Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cellsQ43844097
Transcriptional targeting of adenoviral gene delivery into migrating wound keratinocytes using FiRE, a growth factor-inducible regulatory elementQ45872406
Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancerQ47724219
Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3.Q52543659
P433issue48
P407language of work or nameEnglishQ1860
P304page(s)46338-46346
P577publication date2002-09-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleSmad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways
P478volume277

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