The Biology of Eosinophils and Their Role in Asthma

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The Biology of Eosinophils and Their Role in Asthma is …
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P356DOI10.3389/FMED.2017.00093
P932PMC publication ID5491677
P698PubMed publication ID28713812

P50authorClaire N McBrienQ57305810
P2093author name stringAndrew Menzies-Gow
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Eosinophils are required for the maintenance of plasma cells in the bone marrow.Q51024387
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Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway.Q51699174
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Hierarchy of eosinophil chemoattractants: role of p38 mitogen-activated protein kinaseQ60734268
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defenseQ61959753
Mast Cell and Eosinophil Distribution and Activation in Human Endometrium throughout the Menstrual Cycle1Q61989613
Eosinophils from patients with blood eosinophilia express transforming growth factor beta 1Q67715407
Comparison of airway and blood eosinophil function after in vivo antigen challengeQ67887085
Eosinophil cationic protein alters proteoglycan metabolism in human lung fibroblast culturesQ68003083
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthmaQ68052191
Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to a distinct crystalloid-free granule population in mature human eosinophilsQ69031879
Nerve growth factor prevents apoptosis of rat peritoneal mast cells through the trk proto-oncogene receptorQ70837508
Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammationQ71540543
Eosinophilic inflammation is associated with elevation of interleukin-5 in the airways of patients with spontaneous symptomatic asthmaQ71586532
Increased levels of CD34+ hemopoietic progenitor cells in atopic subjectsQ71778422
Human eosinophils stimulate DNA synthesis and matrix production in dermal fibroblastsQ72854483
Effects of TNF-alpha, IFN-gamma and IL-beta on normal human bronchial epithelial cellsQ72998977
Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmaticsQ73202075
Involvement of complement and fibronectin in eosinophil-mediated damage to Nippostrongylus brasiliensis larvaeQ73341467
Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesisQ73431447
Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitisQ73651422
Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrowQ74357254
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Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitisQ77660836
CD34(+)/interleukin-5Ralpha messenger RNA+ cells in the bronchial mucosa in asthma: potential airway eosinophil progenitorsQ77742474
Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathologyQ78396719
Early thickening of the reticular basement membrane in children with difficult asthmaQ78719252
Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophilsQ79856676
The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammationQ80455192
The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensisQ80735385
Role of selectins in the intestinal epithelial migration of eosinophilsQ81272388
Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alphaQ81317318
Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathwayQ81672236
Antigen-Specific IgG and IgA, but Not IgE, Activate the Effector Functions of Eosinophils in the Presence of AntigenQ84792417
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Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generationQ34209721
Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophiliaQ34230967
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Systemic side effects of inhaled corticosteroids in patients with asthmaQ34484565
The expanding role(s) of eosinophils in health and diseaseQ34641880
Eosinophil inversely associates with type 2 diabetes and insulin resistance in Chinese adultsQ34872477
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The regulation of immunoglobulin E class-switch recombinationQ35209475
Purification of human eosinophil-derived neurotoxinQ35468177
Topographical continuity of bacterial populations in the healthy human respiratory tractQ35528519
A defective type 1 response to rhinovirus in atopic asthma.Q35535100
Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor beta 1 gene (TGF beta 1).Q35602823
Expression and activation of TGF-beta isoforms in acute allergen-induced remodelling in asthmaQ35844179
Nerve growth factor and its receptors in asthma and inflammationQ35908608
Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmaticsQ36001230
Eosinophil crystalloid granules: structure, function, and beyondQ36091297
The role of eosinophils in the pathogenesis of asthmaQ36095350
Refining the definition of hypereosinophilic syndromeQ36103687
Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivoQ36369717
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirusQ36403355
Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: a role for transforming growth factor beta (TGF-beta)Q36429520
IL-13 induces a bronchial epithelial phenotype that is profibroticQ36537810
IL-5 drives eosinophils from bone marrow to blood and tissues in a guinea-pig model of visceral larva migrans syndromeQ36628083
Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditionsQ36655884
IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligandQ36696547
The regulatory role of TGF-beta in airway remodeling in asthmaQ36746333
Eosinophil trafficking in allergy and asthma.Q36811728
Eosinophils in innate immunity: an evolving storyQ36921021
Eosinophils secrete IL-4 to facilitate liver regenerationQ36932394
Up-regulation and activation of eosinophil integrins in blood and airway after segmental lung antigen challengeQ36980346
Interaction between allergy and innate immunity: model for eosinophil regulation of epithelial cell interferon expressionQ37003801
The role of the complement anaphylatoxins in the recruitment of eosinophilsQ37015015
Reversal of allergen-induced airway remodeling by CysLT1 receptor blockadeQ37144437
Lymph node trafficking and antigen presentation by endobronchial eosinophilsQ37176309
IDO: a double-edged sword for T(H)1/T(H)2 regulationQ37281950
Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiationQ37374729
Biology of the eosinophilQ37397520
Thymic indoleamine 2,3-dioxygenase-positive eosinophils in young children: potential role in maturation of the naive immune systemQ37413688
An update on the role of leukotrienes in asthmaQ37633331
Mepolizumab and exacerbations of refractory eosinophilic asthmaQ37711391
Eosinophils in health and disease: the LIAR hypothesisQ37743621
Eosinophil granule proteins: form and functionQ38209847
Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factorQ38361721
The Eosinophil in InfectionQ38675311
Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trialQ39408906
The eosinophil and the pathophysiology of asthmaQ39730322
Bactericidal action of eosinophils from normal human bloodQ40161332
Eosinophil-derived cationic proteins activate the synthesis of remodeling factors by airway epithelial cellsQ40230341
Estimation of kinetic parameters of neutrophilic, eosinophilic, and basophilic granulocytes in human bloodQ40243844
Blood eosinophil count and prospective annual asthma disease burden: a UK cohort studyQ40401116
Tumor necrosis factor-alpha induces transforming growth factor-beta1 expression in lung fibroblasts through the extracellular signal-regulated kinase pathway.Q40470243
Cutting edge: human eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenaseQ40495420
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin productionQ40849898
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.Q41021385
Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trialsQ41452053
The immunology of asthmaQ41673436
Requirement for IL-13 independently of IL-4 in experimental asthmaQ41881960
Transforming growth factor-beta induces airway smooth muscle hypertrophyQ42005944
Human airway smooth muscle promotes eosinophil differentiationQ42170514
Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.Q42258225
Eosinophils in the human corpus luteum: the role of RANTES and eotaxin in eosinophil attraction into periovulatory structuresQ42496740
A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in miceQ43172485
2.5S nerve growth factor enhances survival, phagocytosis, and superoxide production of murine neutrophilsQ43882347
Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-β1.Q43969556
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.Q44247874
Eosinophil Major Basic Protein Stimulates Neutrophil Superoxide Production by a Class IA Phosphoinositide 3-Kinase and Protein Kinase C-ζ-Dependent PathwayQ44590783
P921main subjectasthmaQ35869
P304page(s)93
P577publication date2017-06-30
P1433published inFrontiers in MedicineQ27726181
P1476titleThe Biology of Eosinophils and Their Role in Asthma
P478volume4

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