Benralizumab: From the Basic Mechanism of Action to the Potential Use in the Biological Therapy of Severe Eosinophilic Asthma.

scientific article published on 10 May 2018

Benralizumab: From the Basic Mechanism of Action to the Potential Use in the Biological Therapy of Severe Eosinophilic Asthma. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2018/4839230
P932PMC publication ID5971345
P698PubMed publication ID29862274

P50authorMaria Teresa BuscetiQ124854007
Alessandro VatrellaQ48541083
Rosa TerraccianoQ55080364
Girolamo PelaiaQ87123110
Corrado PelaiaQ94456854
P2093author name stringNicola Lombardo
Cecilia Calabrese
Eugenio Garofalo
P2860cites workRole of biologics in severe eosinophilic asthma - focus on reslizumabQ26738503
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Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophiliaQ34230967
Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe AsthmaQ34557028
Mitogen-activated protein kinases and asthmaQ35865902
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Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulationQ36401490
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Targeting eosinophils in allergy, inflammation and beyondQ38075409
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New Anti-Eosinophil Drugs for Asthma and COPD: Targeting the Trait!Q39352939
Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trialQ39408906
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Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trialQ40198084
Interleukin-5 and its receptor system: implications in the immune system and inflammation.Q40602176
The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicityQ40690773
The immunology of asthmaQ41673436
Regulation of interleukin-5-induced beta2-integrin adhesion of human eosinophils by phosphoinositide 3-kinaseQ42066789
Eosinophilic asthma: insights into the effects of reducing IL-5 receptor-positive cell levelsQ42825415
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthmaQ43049820
Sputum CD34+IL-5Ralpha+ cells increase after allergen: evidence for in situ eosinophilopoiesisQ44663899
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IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophilsQ45140680
Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumabQ45676532
Asthma and corticosteroids: time for a more precise approach to treatmentQ46072029
Biological mechanisms underlying the clinical effects of allergen-specific immunotherapy in asthmatic childrenQ47429419
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Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized placebo-controlled trialsQ47686042
Severe and Difficult-to-Treat Asthma in AdultsQ47848891
Benralizumab attenuates airway eosinophilia in prednisone-dependent asthmaQ49572572
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Important and specific role for basophils in acute allergic reactionsQ50065229
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Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition.Q51598582
Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia.Q51611177
Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthma.Q51704000
Reductions in eosinophil biomarkers by benralizumab in patients with asthma.Q53641303
Mucosal Inflammation and AsthmaQ59685309
MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity functionQ60632052
The activation of the Jak-STAT 1 signaling pathway by IL-5 in eosinophilsQ71848076
Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasoneQ73098618
ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesisQ73643163
The differential role of extracellular signal-regulated kinases and p38 mitogen-activated protein kinase in eosinophil functionsQ74108345
The mechanism of IL-5 signal transductionQ77217607
AsthmaQ89218803
AsthmaQ89723811
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectasthmaQ35869
globulinsQ321710
monoclonal antibodyQ422248
blood proteinsQ425056
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)4839230
P577publication date2018-05-10
P1433published inBioMed Research InternationalQ17509958
P1476titleBenralizumab: From the Basic Mechanism of Action to the Potential Use in the Biological Therapy of Severe Eosinophilic Asthma.
P478volume2018

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cites work (P2860)
Q89941328Effects of the first three doses of benralizumab on symptom control, lung function, blood eosinophils, oral corticosteroid intake, and nasal polyps in a patient with severe allergic asthma
Q64113098Efficacy and steroid-sparing effect of benralizumab: has it an advantage over its competitors?
Q92536062Interleukin-5 in the Pathophysiology of Severe Asthma
Q92504767Monoclonal antibodies in type 2 asthma: a systematic review and network meta-analysis
Q58583982Omalizumab, the first available antibody for biological treatment of severe asthma: more than a decade of real-life effectiveness
Q90333130Role of Biologics in Asthma
Q98772414The use of biologics in children with allergic rhinitis and chronic rhinosinusitis: Current updates

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