Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork

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Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork is …
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scholarly articleQ13442814

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P356DOI10.1167/IOVS.16-19610
P932PMC publication ID5102566
P698PubMed publication ID27820874

P2093author name stringJ Cameron Millar
Gulab S Zode
Tien N Phan
Ramesh B Kasetti
P2860cites workGlucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissuesQ24291384
In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectinQ24292082
The number of people with glaucoma worldwide in 2010 and 2020Q24679554
A molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein responseQ26828355
Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucomaQ26851287
Presence of an established calcification marker in trabecular meshwork tissue of glaucoma donorsQ33288802
Identification of a gene that causes primary open angle glaucoma.Q34414141
Interaction of recombinant myocilin with the matricellular protein SPARC: functional implicationsQ34646595
Myocilin and glaucoma: facts and ideas.Q34768697
Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stressQ35128563
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucomaQ35131549
Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.Q35187142
Molecular chaperone function for myocilinQ35247676
Increased Endoplasmic Reticulum Stress in Human Glaucomatous Trabecular Meshwork Cells and TissuesQ35745200
Hyaluronic acid increases MMP-2 and MMP-9 expressions in cultured trabecular meshwork cells from patients with primary open-angle glaucoma.Q35956970
Extracellular matrix in the trabecular meshworkQ36646381
Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in miceQ36730478
Dual localization of wild-type myocilin in the endoplasmic reticulum and extracellular compartment likely occurs due to its incomplete secretion.Q37126077
Cellular fibronectin expression in human trabecular meshwork and induction by transforming growth factor-β2Q37237085
Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucomaQ37726620
MMPs in the trabecular meshwork: promising targets for future glaucoma therapies?Q38165134
Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cellsQ38518594
Reversal of mutant myocilin non-secretion and cell killing: implications for glaucomaQ40569319
Neuronal death in glaucomaQ40827206
Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humorQ40832933
Cytoskeletal changes in cultured human glaucoma trabecular meshwork cellsQ41336599
Activation mechanisms of matrix metalloproteinases.Q41482018
Aggregated myocilin induces russell bodies and causes apoptosis: implications for the pathogenesis of myocilin-caused primary open-angle glaucomaQ42111387
Expression of matrix metalloproteinases and their inhibitors in human trabecular meshwork cellsQ42445149
Expression of matrix metalloproteinases and inhibitor by human trabecular meshworkQ42470834
Cross-linked actin networks (CLANs) in the trabecular meshwork of the normal and glaucomatous human eye in situQ42601515
Biochemical purification of native immune protein complexesQ43238054
Immunomicroscopical study of type VI collagen in the trabecular meshwork of normal and glaucomatous eyesQ44404688
Open-angle glaucoma risk factors applied to clinical area.Q46508468
Extracellular trafficking of myocilin in human trabecular meshwork cellsQ46535311
Strain and Age Effects on Aqueous Humor Dynamics in the MouseQ46676393
Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cellsQ46930398
Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshworkQ47673403
Noninvasive measurement of rodent intraocular pressure with a rebound tonometerQ48751704
The effect of TGF-beta2 on human trabecular meshwork extracellular proteolytic system.Q53852677
Ultrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma (POAG).Q54046706
Tonography Demonstrates Reduced Facility of Outflow of Aqueous Humor in Myocilin Mutation CarriersQ57252163
Primary open-angle glaucomaQ57728691
Why is intraocular pressure elevated in chronic simple glaucoma? Anatomical considerationsQ70449534
Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normalsQ70571024
Regulation of the levels of human trabecular matrix metalloproteinases and inhibitor by interleukin-1 and dexamethasoneQ72569262
Effect of matrix metalloproteinases activity on outflow in perfused human organ cultureQ77695628
Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucomaQ79837331
Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma-causing myocilin mutantsQ80795418
Assessment of Aqueous Humor Dynamics in the Mouse by a Novel Method of Constant-Flow InfusionQ85068101
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectextracellular matrixQ193825
P304page(s)6058-6069
P577publication date2016-11-01
P1433published inInvestigative Ophthalmology Visual ScienceQ6060707
P1476titleExpression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork
P478volume57

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cites work (P2860)
Q101402571ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load
Q42653635CRISPR-Cas9-based treatment of myocilin-associated glaucoma
Q47333845Dexamethasone-Induced Ocular Hypertension in Mice: Effects of Myocilin and Route of Administration
Q55002650Genomic Locus Modulating IOP in the BXD RI Mouse Strains.
Q52314492Glaucoma pathogenesis and neurotrophins: Focus on the Molecular and Genetic basis for Therapeutic prospects.
Q52663098Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior.
Q91729475Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma
Q47552785Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension in mice
Q58567751Glucose-regulated protein 78 in the aqueous humor in diabetic macular edema patients
Q44560624Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork
Q93156976Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation
Q45872509Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway
Q64997525Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review).
Q97883064Protective Effects of Rapamycin on Trabecular Meshwork Cells in Glucocorticoid-Induced Glaucoma Mice
Q54977773Research progress on human genes involved in the pathogenesis of glaucoma (Review).
Q54979452Transforming growth factor β2 (TGFβ2) signaling plays a key role in glucocorticoid-induced ocular hypertension.