| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S1350-9462(02)00010-1 |
| P698 | PubMed publication ID | 12150989 |
| P50 | author | Ernst R Tamm | Q54198073 |
| P2093 | author name string | Ernst R Tamm | |
| P2860 | cites work | Juvenile open angle glaucoma: fine mapping of the TIGR gene to 1q24.3-q25.2 and mutation analysis | Q74268817 |
| Ultrastructural localization of myocilin in human trabecular meshwork cells and tissues | Q74320247 | ||
| TIGR gene in primary open-angle glaucoma and steroid-induced glaucoma | Q74338214 | ||
| Variations in the myocilin gene in patients with open-angle glaucoma | Q74740868 | ||
| EFFECT OF CORTICOSTEROIDS ON INTRAOCULAR PRESSURE AND FLUID DYNAMICS. I. THE EFFECT OF DEXAMETHASONE IN THE NORMAL EYE | Q76603787 | ||
| EFFECT OF CORTICOSTEROIDS ON INTRAOCULAR PRESSURE AND FLUID DYNAMICS. II. THE EFFECT OF DEXAMETHASONE IN THE GLAUCOMATOUS EYE | Q76603792 | ||
| Novel trabecular meshwork inducible glucocorticoid response mutation in an eight-generation juvenile-onset primary open-angle glaucoma pedigree | Q77352435 | ||
| Myocilin is associated with mitochondria in human trabecular meshwork cells | Q77537688 | ||
| The mouse anterior chamber angle and trabecular meshwork develop without cell death | Q24797197 | ||
| Alpha-crystallin can function as a molecular chaperone | Q29618672 | ||
| Regulation of cardiac alpha-myosin heavy chain gene transcription by a contractile-responsive E-box binding protein | Q32097458 | ||
| Effects of pilocarpine on the morphology of the human outflow apparatus | Q33650681 | ||
| A novel Asp380Ala mutation in the GLC1A/myocilin gene in a family with juvenile onset primary open angle glaucoma. | Q33681582 | ||
| Novel TIGR/MYOC mutations in families with juvenile onset primary open angle glaucoma | Q33681656 | ||
| Roles of molecular chaperones in cytoplasmic protein folding | Q33874583 | ||
| The function of alpha-crystallin in vision | Q33874602 | ||
| ER stress response: getting the UPR hand on misfolded proteins | Q33970911 | ||
| Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function | Q34012751 | ||
| Clinical phenotype of juvenile-onset primary open-angle glaucoma linked to chromosome 1q. | Q34062593 | ||
| Identification of a gene that causes primary open angle glaucoma. | Q34414141 | ||
| A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping | Q34427530 | ||
| The TIGR/MYOC gene and glaucoma: opportunities for new understandings | Q34560039 | ||
| Characterization and comparison of the human and mouse GLC1A glaucoma genes | Q35021292 | ||
| Molecular cloning of olfactomedin, an extracellular matrix protein specific to olfactory neuroepithelium | Q36310390 | ||
| Structure of the leucine zipper | Q36354797 | ||
| A complex array of positive and negative elements regulates the chicken alpha A-crystallin gene: involvement of Pax-6, USF, CREB and/or CREM, and AP-1 proteins | Q36669554 | ||
| Four structurally distinct neuron-specific olfactomedin-related glycoproteins produced by differential promoter utilization and alternative mRNA splicing from a single gene | Q36724131 | ||
| Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product | Q36864380 | ||
| Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin. | Q36880285 | ||
| The basic helix-loop-helix-zipper transcription factor USF1 regulates expression of the surfactant protein-A gene. | Q36881326 | ||
| Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse | Q37530481 | ||
| Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells | Q37585956 | ||
| Upstream stimulatory factor 1 regulates osteopontin expression in smooth muscle cells | Q38322659 | ||
| Immunofluorescence method for quantifying the trabecular meshwork glucocorticoid response (TIGR) protein in trabecular meshwork and Schlemm's canal cells | Q39521760 | ||
| Participation of upstream stimulator factor (USF) in cadmium-induction of the mouse metallothionein-I gene | Q39725591 | ||
| Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen activator inhibitor gene | Q40678620 | ||
| Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor | Q40832933 | ||
| Molecular evolution of olfactomedin | Q40856548 | ||
| A cellular assay distinguishes normal and mutant TIGR/myocilin protein | Q40920038 | ||
| Transcriptional regulation of the mouse alpha A-crystallin gene: binding of USF to the -7/+5 region | Q41128227 | ||
| Topical prostaglandin F2alpha treatment reduces collagen types I, III, and IV in the monkey uveoscleral outflow pathway | Q41672660 | ||
| The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements | Q42217891 | ||
| Contractile cells in the human scleral spur | Q42461718 | ||
| Age-related changes of the ciliary muscle in comparison with changes induced by treatment with prostaglandin F2 alpha. An ultrastructural study in rhesus and cynomolgus monkeys. | Q42483741 | ||
| Regulation of human myocilin/TIGR gene transcription in trabecular meshwork cells and astrocytes: role of upstream stimulatory factor | Q42492150 | ||
| Prevalence of mutations in TIGR/Myocilin in patients with adult and juvenile primary open-angle glaucoma | Q42540946 | ||
| Molecular cloning and expression profile of rat myocilin | Q42627180 | ||
| Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma | Q42634618 | ||
| Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development | Q42652061 | ||
| Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma | Q42665063 | ||
| Genomic organization of the human myocilin gene (MYOC) responsible for primary open angle glaucoma (GLC1A). | Q42671610 | ||
| Characterization of the mouse Myoc/Tigr gene. | Q42677674 | ||
| Mouse myocilin (Myoc) gene expression in ocular tissues | Q42681473 | ||
| Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. | Q42804627 | ||
| Promoter mutations of myocilin gene in Japanese patients with open angle glaucoma including normal tension glaucoma | Q43092834 | ||
| Mutations in the TIGR gene in familial primary open-angle glaucoma in Japan | Q43104803 | ||
| Mutations of the TIGR/MYOC gene in primary open-angle glaucoma in Korea | Q43218500 | ||
| Increased matrix metalloproteinases 1, 2, and 3 in the monkey uveoscleral outflow pathway after topical prostaglandin F(2 alpha)-isopropyl ester treatment | Q43493260 | ||
| Expression of myocilin/TIGR in normal and glaucomatous primate optic nerves | Q43874938 | ||
| Altered secretion of a TIGR/MYOC mutant lacking the olfactomedin domain | Q44799120 | ||
| Evolution of olfactomedin. Structural constraints and conservation of primary sequence motifs | Q44870795 | ||
| Adenoviral reporter gene transfer to the human trabecular meshwork does not alter aqueous humor outflow. Relevance for potential gene therapy of glaucoma | Q45862094 | ||
| Biosynthesis and degradation of CFTR. | Q45968383 | ||
| Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells | Q46096320 | ||
| Regulation of TIGR/MYOC gene expression in human trabecular meshwork cells | Q46116596 | ||
| Characterization of the murine TIGR/myocilin gene | Q46347398 | ||
| Analysis of myocilin mutations in 1703 glaucoma patients from five different populations | Q46636264 | ||
| Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells | Q46769376 | ||
| Homozygotes carrying an autosomal dominant TIGR mutation do not manifest glaucoma | Q47714167 | ||
| A novel mutation in the GLC1A gene causes juvenile open-angle glaucoma in 4 families from the Italian region of Puglia | Q47929664 | ||
| Differentially expressed olfactomedin-related glycoproteins (Pancortins) in the brain | Q48038773 | ||
| Expression pattern and in situ localization of the mouse homologue of the human MYOC (GLC1A) gene in adult brain. | Q48214997 | ||
| A GLC1A gene Gln368Stop mutation in a patient with normal-tension open-angle glaucoma. | Q48233259 | ||
| Non-invasive observation of repeated adenoviral GFP gene delivery to the anterior segment of the monkey eye in vivo. | Q51191793 | ||
| Molecular and clinical evaluation of a patient hemizygous for TIGR/MYOC. | Q53882960 | ||
| Association of a single nucleotide polymorphism in the TIGR/MYOCILIN gene promoter with the severity of primary open-angle glaucoma. | Q53884723 | ||
| Immunohistochemical localization of MYOC/TIGR protein in the trabecular tissue of normal and glaucomatous eyes. | Q53895439 | ||
| Myocilin Gln368stop mutation and advanced age as risk factors for late-onset primary open-angle glaucoma. | Q53911831 | ||
| Detection of a new TIGR gene mutation in a Japanese family with primary open angle glaucoma. | Q53931775 | ||
| Clinical phenotype of a Japanese family with primary open angle glaucoma caused by a Pro370Leu mutation in the MYOC/TIGR gene. | Q53931776 | ||
| Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A) | Q53956831 | ||
| Identification of a new 'TIGR' mutation in a family with juvenile-onset primary open angle glaucoma. | Q53963110 | ||
| Genetic linkage of familial open angle glaucoma to chromosome 1q21–q31 | Q57785250 | ||
| Novel mutations in the TIGR gene in early and late onset open angle glaucoma | Q60653031 | ||
| Inefficient processing of an olfactomedin-deficient myocilin mutant: potential physiological relevance to glaucoma | Q64379776 | ||
| Olfactomedin: purification, characterization, and localization of a novel olfactory glycoprotein | Q67974166 | ||
| Morphological study of the anterior segment of cynomolgus monkey eyes following treatment with prostaglandin F2 alpha | Q67979433 | ||
| Electron microscopic studies on the trabecular meshwork in two cases of corticosteroid-glaucoma | Q68671386 | ||
| Pilocarpine antagonizes prostaglandin F2 alpha-induced ocular hypotension in monkeys. Evidence for enhancement of Uveoscleral outflow by prostaglandin F2 alpha | Q68772703 | ||
| Why is intraocular pressure elevated in chronic simple glaucoma? Anatomical considerations | Q70449534 | ||
| Identification of a contractile-responsive element in the cardiac alpha-myosin heavy chain gene | Q70825975 | ||
| Aqueous Humor in Glaucomatous Eyes Contains an Increased Level of TGF-β2 | Q72113985 | ||
| Genetic linkage of autosomal dominant juvenile glaucoma to 1q21-q31 in three affected pedigrees | Q72195874 | ||
| Myocilin expression in the astrocytes of the optic nerve head | Q73067298 | ||
| Expression of the TIGR gene in the iris, ciliary body, and trabecular meshwork of the human eye | Q73087281 | ||
| Ultrastructural changes in the trabecular meshwork of human eyes treated with corticosteroids | Q73167706 | ||
| A rat model of chronic pressure-induced optic nerve damage | Q73202589 | ||
| Clinical features of five pedigrees genetically linked to the juvenile glaucoma locus on chromosome 1q21-q31 | Q73212560 | ||
| TIGR/myocilin in human aqueous humor | Q73235405 | ||
| Childhood-onset primary open angle glaucoma in a Canadian kindred: clinical and molecular genetic features | Q73317435 | ||
| Novel TIGR sequence alteration Val53Ala | Q73375723 | ||
| Ultrastructural changes in the trabecular meshwork of juvenile glaucoma | Q73400640 | ||
| Transient loss of alphaB-crystallin: an early cellular response to mechanical stretch | Q73442862 | ||
| Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head | Q73853312 | ||
| P433 | issue | 4 | |
| P304 | page(s) | 395-428 | |
| P577 | publication date | 2002-07-01 | |
| P1433 | published in | Progress in Retinal and Eye Research | Q15760062 |
| P1476 | title | Myocilin and glaucoma: facts and ideas | |
| P478 | volume | 21 |
| Q37415633 | A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture |
| Q42940255 | A sequential, multiple-treatment, targeted approach to reduce wound healing and failure of glaucoma filtration surgery in a rabbit model (an American Ophthalmological Society thesis). |
| Q34684652 | A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina |
| Q42111387 | Aggregated myocilin induces russell bodies and causes apoptosis: implications for the pathogenesis of myocilin-caused primary open-angle glaucoma |
| Q34361564 | Aqueous humor rapidly stimulates myocilin secretion from human trabecular meshwork cells |
| Q58616785 | Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells |
| Q44977209 | Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model |
| Q33808845 | Biophysical characterization of the olfactomedin domain of myocilin, an extracellular matrix protein implicated in inherited forms of glaucoma |
| Q35147711 | Cellular processing of myocilin. |
| Q99567366 | Characterization of a novel mutation in the MYOC gene in a Chinese family with primary open‑angle glaucoma |
| Q40103210 | Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease. |
| Q62637501 | Comprehensive sequencing of the myocilin gene in a selected cohort of severe primary open-angle glaucoma patients |
| Q36499378 | Contributions of MYOC and CYP1B1 mutations to JOAG |
| Q36118249 | Corticosteroid-induced glaucoma: a review of the literature |
| Q38266837 | Could mineralocorticoids play a role in the pathophysiology of open angle glaucoma? |
| Q28483730 | Cystatin a, a potential common link for mutant myocilin causative glaucoma |
| Q91887225 | Differential Misfolding Properties of Glaucoma-Associated Olfactomedin Domains from Humans and Mice |
| Q42633357 | Durable, safe, multi-gene lentiviral vector expression in feline trabecular meshwork |
| Q34121388 | Effects of transforming growth factor-β2 on myocilin expression and secretion in human primary cultured trabecular meshwork cells |
| Q41936907 | Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression |
| Q34005691 | Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration |
| Q34452059 | Establishment of inducible wild type and mutant myocilin-GFP-expressing RGC5 cell lines |
| Q33705286 | Evaluation of MYOC, ACAN, HGF, and MET as candidate genes for high myopia in a Han Chinese population |
| Q42695733 | Expression and characterization of the olfactomedin domain of human myocilin |
| Q37404450 | Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork |
| Q33882506 | Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesis |
| Q40340063 | Gene transfer to trabecular meshwork endothelium via direct injection into the Schlemm canal and in vivo toxicity study |
| Q38164595 | Genetics of primary open angle glaucoma |
| Q35584503 | Glaucoma in iran and contributions of studies in iran to the understanding of the etiology of glaucoma |
| Q37193799 | Glaucoma-associated myocilin: a better understanding but much more to learn |
| Q36075362 | Glaucomatous MYOC mutations activate the IL-1/NF-κB inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells |
| Q36978194 | Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin. |
| Q28504823 | Interaction of myocilin with gamma-synuclein affects its secretion and aggregation |
| Q50546080 | Intravitreal triamcinolone acetonide induced changes in the anterior segment in a pig model of branch retinal vein occlusion. |
| Q37895102 | Keeping an eye on myocilin: a complex molecule associated with primary open-angle glaucoma susceptibility. |
| Q38822902 | Low-dose rotenone exposure induces early senescence leading to late apoptotic signaling cascade in human trabecular meshwork (HTM) cell line: An in vitro glaucoma model |
| Q39303267 | Major review: Molecular genetics of primary open-angle glaucoma |
| Q44509142 | Mechanotransduction channels of the trabecular meshwork |
| Q47347537 | Methods for Analyzing Endoplasmic Reticulum Stress in the Trabecular Meshwork of Glaucoma Models |
| Q24306535 | Mitochondrial association of myocilin, product of a glaucoma gene, in human trabecular meshwork cells |
| Q35247676 | Molecular chaperone function for myocilin |
| Q35921483 | Multipotent stem cells from trabecular meshwork become phagocytic TM cells |
| Q58612006 | Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle |
| Q35131549 | Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma |
| Q40159820 | Myocilin allele-specific glaucoma phenotype database |
| Q37249806 | Myocilin and Optineurin: Differential Characteristics and Functional Consequences |
| Q45225447 | Myocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions |
| Q84367827 | Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma |
| Q24328948 | Myocilin is a modulator of Wnt signaling |
| Q37077018 | Myocilin polymorphisms and high myopia in subjects of European origin |
| Q24322728 | Myocilin promotes substrate adhesion, spreading and formation of focal contacts in podocytes and mesangial cells |
| Q37683314 | Myocilin regulates cell proliferation and survival |
| Q42007390 | Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain |
| Q24306176 | Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine/threonine kinase signaling pathway |
| Q34116120 | Olfactomedin domain-containing proteins: possible mechanisms of action and functions in normal development and pathology |
| Q35140846 | Ophthalmic drug discovery |
| Q47352375 | Overexpression of myocilin in cultured human trabecular meshwork cells |
| Q33400356 | Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma |
| Q35522213 | Perfusion-cultured bovine anterior segments as an ex vivo model for studying glucocorticoid-induced ocular hypertension and glaucoma |
| Q43225793 | Pharmacotherapeutic efficacy of preservative-free intravitreal triamcinolone acetonide |
| Q90308411 | Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019 |
| Q37159445 | Pro370Leu mutant myocilin disturbs the endoplasm reticulum stress response and mitochondrial membrane potential in human trabecular meshwork cells. |
| Q37166653 | Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells. |
| Q33531818 | Protein expression in human trabecular meshwork: downregulation of RhoGDI by dexamethasone in vitro |
| Q24294431 | Protein profile of exosomes from trabecular meshwork cells |
| Q36432134 | Protein quality control: the who's who, the where's and therapeutic escapes |
| Q40569319 | Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma |
| Q24299747 | Rho GTPase and cAMP/protein kinase A signaling mediates myocilin-induced alterations in cultured human trabecular meshwork cells |
| Q36676552 | Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ |
| Q28581903 | Secreted glycoprotein myocilin is a component of the myelin sheath in peripheral nerves |
| Q35027124 | Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of primary open-angle glaucoma. |
| Q53826183 | Simulations and Experiments Delineate Amyloid Fibrilization by Peptides Derived from Glaucoma-Associated Myocilin. |
| Q30394249 | Stem cell marker olfactomedin 4: critical appraisal of its characteristics and role in tumorigenesis |
| Q38963936 | Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine |
| Q35865463 | Substratum stiffness and latrunculin B regulate matrix gene and protein expression in human trabecular meshwork cells |
| Q36481798 | Suppression of keratoepithelin and myocilin by small interfering RNA (an American Ophthalmological Society thesis). |
| Q28544814 | Systems level analysis and identification of pathways and networks associated with liver fibrosis |
| Q38572659 | Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma |
| Q38107689 | The cell stress machinery and retinal degeneration |
| Q53848829 | The expression of myocilin during murine eye development. |
| Q38153723 | The genetics of intraocular pressure |
| Q24310739 | The glycoprotein hGC-1 binds to cadherin and lectins |
| Q36021030 | The intrinsic stiffness of human trabecular meshwork cells increases with senescence. |
| Q30369977 | The olfactomedin domain from gliomedin is a β-propeller with unique structural properties. |
| Q37294759 | The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway |
| Q35083487 | The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder |
| Q35656032 | Thermally labile components of aqueous humor potently induce osteogenic potential in adipose-derived mesenchymal stem cells. |
| Q35921479 | Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma. |
| Q34159558 | Transgenic mice expressing mutated Tyr437His human myocilin develop progressive loss of retinal ganglion cell electrical responsiveness and axonopathy with normal iop. |
| Q35919067 | Unaltered myocilin expression in the blood of primary open angle glaucoma patients |
| Q34427630 | Wnt activation by wild type and mutant myocilin in cultured human trabecular meshwork cells |
| Q80051825 | [Etiopathogeny of intraocular pressure modifications in uveitis] |
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