Myocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions

scientific article published on 2 November 2004

Myocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YEXCR.2004.09.026
P698PubMed publication ID15652337

P2093author name stringDonna M Peters
Kathleen Herbert
Brenda Biddick
Jennifer A Peterson
P2860cites workPaxillin and focal adhesion signallingQ28142041
A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migrationQ28210855
Focal adhesions, contractility, and signalingQ28299775
The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state?Q28361886
Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblastsQ28576503
Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of FunctionQ34012751
Identification of a gene that causes primary open angle glaucoma.Q34414141
A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mappingQ34427530
A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formationQ34437584
Myocilin and glaucoma: facts and ideas.Q34768697
Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibersQ35061017
Localization of cell surface sites involved in fibronectin fibrillogenesisQ36225282
Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene productQ36864380
Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13.Q36867742
Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin.Q36880285
Alternative splicing of the IIICS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading.Q38292243
Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humorQ40832933
Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucomaQ42665063
Characterization of the mouse Myoc/Tigr gene.Q42677674
A multidomain TIGR/olfactomedin protein family with conserved structural similarity in the N-terminal region and conserved motifs in the C-terminal regionQ42680356
Mouse myocilin (Myoc) gene expression in ocular tissuesQ42681473
Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cellsQ46769376
Extracellular myocilin affects activity of human trabecular meshwork cellsQ47620924
A mechanism for trabecular meshwork cell retraction: ethacrynic acid initiates the dephosphorylation of focal adhesion proteins.Q52529118
Effect of heparin II domain of fibronectin on aqueous outflow in cultured anterior segments of human eyes.Q52552355
Immunohistochemical localization of MYOC/TIGR protein in the trabecular tissue of normal and glaucomatous eyes.Q53895439
Binding and factor XIIIa-mediated cross-linking of a 27-kilodalton fragment of fibronectin to Staphylococcus aureusQ71279990
TIGR/myocilin in human aqueous humorQ73235405
Fibronectin fibrillogenesis involves the heparin II binding domain of fibronectinQ74105765
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)218-228
P577publication date2004-11-02
P1433published inExperimental Cell ResearchQ1524289
P1476titleMyocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions
P478volume303

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cites work (P2860)
Q35075305A role for myocilin in receptor-mediated endocytosis.
Q38166800Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma
Q36754117Biological properties of trabecular meshwork cells
Q33808845Biophysical characterization of the olfactomedin domain of myocilin, an extracellular matrix protein implicated in inherited forms of glaucoma
Q41936907Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression
Q37286584Functional properties of fibronectin in the trabecular meshwork
Q33763673Gene therapy targeting glaucoma: where are we?
Q37193799Glaucoma-associated myocilin: a better understanding but much more to learn
Q36075362Glaucomatous MYOC mutations activate the IL-1/NF-κB inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells
Q36008830Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells
Q34646595Interaction of recombinant myocilin with the matricellular protein SPARC: functional implications
Q37895102Keeping an eye on myocilin: a complex molecule associated with primary open-angle glaucoma susceptibility.
Q33820048Matricellular proteins in the trabecular meshwork: review and update
Q37678801Molecular complexity of primary open angle glaucoma: current concepts
Q37249806Myocilin and Optineurin: Differential Characteristics and Functional Consequences
Q24328948Myocilin is a modulator of Wnt signaling
Q24322728Myocilin promotes substrate adhesion, spreading and formation of focal contacts in podocytes and mesangial cells
Q24339483Myocilin stimulates osteogenic differentiation of mesenchymal stem cells through mitogen-activated protein kinase signaling
Q24306176Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine/threonine kinase signaling pathway
Q41755679NFATc1 activity regulates the expression of myocilin induced by dexamethasone
Q45872509Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway
Q36143392Optimized bacterial expression of myocilin proteins and functional comparison of bacterial and eukaryotic myocilins.
Q36494535Phosphodiesterase-Ialpha/autotaxin's MORFO domain regulates oligodendroglial process network formation and focal adhesion organization
Q33599524Proteomic differences between male and female anterior cruciate ligament and patellar tendon
Q37163622Regulation of myocilin-associated exosome release from human trabecular meshwork cells
Q33869299Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones
Q37710660The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review
Q36481734The glaucoma-associated olfactomedin domain of myocilin is a novel calcium binding protein
Q35921479Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma.

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