αvβ1 integrin as a novel therapeutic target for tissue fibrosis

scientific article published on October 2016

αvβ1 integrin as a novel therapeutic target for tissue fibrosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.21037/ATM.2016.10.33
P932PMC publication ID5107387
P698PubMed publication ID27867963

P2093author name stringJie-Young Song
Seong-Jun Cho
Kyung-Hee Song
P2860cites workBasic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activityQ41984680
Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null miceQ42563021
Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1Q59066124
Neutralization of transforming growth factor-beta 1 in a mouse model of immune-induced lung fibrosisQ72462880
Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined systemQ72724754
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammationQ81398566
Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesisQ24610450
Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1Q24644444
Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrixQ24678290
Vascular Remodelling and Mesenchymal Transition in Systemic SclerosisQ26749091
Integrins: bidirectional, allosteric signaling machinesQ27860700
Integrins: versatility, modulation, and signaling in cell adhesionQ27860844
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosisQ28137622
TGF-beta signaling and the fibrotic responseQ29620099
Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in miceQ33853415
Role of alphavbeta6 integrin in acute biliary fibrosisQ34088326
Integrating mechanisms of pulmonary fibrosisQ35106452
Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.Q35570438
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitroQ35610349
Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthmaQ35622204
Systemic sclerosis: a prototypic multisystem fibrotic disorderQ35649427
The αvβ1 integrin plays a critical in vivo role in tissue fibrosisQ35703159
BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding proteinQ36118959
Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-cultureQ36220333
Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cellsQ36383154
In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosisQ36553502
Liver fibrosis: cellular mechanisms of progression and resolutionQ36721356
Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen speciesQ36981625
Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumorsQ36999909
Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lungQ37370914
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organsQ37374921
Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesisQ37426714
Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis.Q37644463
Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of sclerodermaQ37712557
Integrins as therapeutic targets: lessons and opportunitiesQ37795552
Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.Q39364702
Role of reactive oxygen species in transforming growth factor-beta1-induced extracellular matrix accumulation in renal tubular epithelial cells.Q39368351
Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progressionQ39974242
P433issue20
P304page(s)411
P577publication date2016-10-01
P1433published inAnnals of Translational MedicineQ26842362
P1476titleαvβ1 integrin as a novel therapeutic target for tissue fibrosis
P478volume4

Reverse relations

cites work (P2860)
Q91621157Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
Q49918232Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis
Q48170058The role of TGF-beta signaling in dendritic cell tolerance

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