Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1

scientific article

Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1091/MBC.9.9.2627
P3181OpenCitations bibliographic resource ID3491211
P932PMC publication ID25536
P698PubMed publication ID9725916
P5875ResearchGate publication ID13559594

P2093author name stringD B Rifkin
F G Giancotti
J G Harpel
J S Munger
P2860cites workInteraction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor betaQ24321274
Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequenceQ24564411
Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding proteinQ24673676
Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanismQ24674746
Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-betaQ24683923
Integrins: versatility, modulation, and signaling in cell adhesionQ27860844
Latent transforming growth factor-beta: structural features and mechanisms of activationQ28238140
Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptorQ28250273
The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell lineQ28257562
Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrilsQ28286838
Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motilityQ28286870
A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5Q28291862
Negative regulation of transforming growth factor-beta by the proteoglycan decorinQ28292224
Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivityQ28304357
A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1)Q28306823
The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectinQ28644401
The transforming growth factor-beta familyQ29615948
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the moleculeQ29616413
The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expressionQ34197959
Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptorQ34686171
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.Q34733220
Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organizationQ36221243
Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cellsQ36383054
Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cellsQ36383154
Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptorsQ36405679
Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cellsQ37375977
Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptorQ37376979
Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.Q38290911
alphavbeta3 integrin mediates the cell-adhesive capacity and biological activity of basic fibroblast growth factor (FGF-2) in cultured endothelial cellsQ38615044
Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptideQ41256244
Integrin signaling: specificity and control of cell survival and cell cycle progressionQ41612555
Calcium as a potential physiological regulator of integrin-mediated cell adhesionQ41691588
Arginine-glycine-aspartic acid adhesion receptorsQ41786100
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrixQ43755354
Regulation of the fibronectin receptor affinity by divalent cations.Q44461951
Role of carbohydrate structures in the binding of beta1-latency-associated peptide to ligands.Q54558054
Cell adhesion protein receptors as targets for transforming growth factor-beta actionQ68830658
Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human lung carcinoma cells of different histotypesQ71604126
Protection of transforming growth factor-beta 1 activity by heparin and fucoidanQ71615229
Release and activation of platelet latent TGF–β in blood clots during dissolution with plasminQ71803700
Biochemical characterization of human osteoclast integrins. Osteoclasts express alpha v beta 3, alpha 2 beta 1, and alpha v beta 1 integrinsQ72865482
Growth factors in the extracellular matrixQ73075408
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)2627-38
P577publication date1998-09-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleInteractions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1
P478volume9

Reverse relations

cites work (P2860)
Q55362406A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation.
Q24292398ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo
Q36117987Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice
Q46739165Activation of TGF-beta1 through up-regulation of TSP-1 by retinoic acid in retinal pigment epithelial cells
Q34265512An examination of the proteolytic activity for bovine pregnancy-associated glycoproteins 2 and 12.
Q40490472Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway
Q91879175BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics
Q36646138Binding of TGF-beta1 latency-associated peptide (LAP) to alpha(v)beta6 integrin modulates behaviour of squamous carcinoma cells
Q34094906Biomarkers of acute lung injury: worth their salt?
Q54491839Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor.
Q77922259Cellular and extracellular biology of the latent transforming growth factor-beta binding proteins
Q37106657Choreographing metastasis to the tune of LTBP.
Q46794933Consequences of epithelial or stromal TGFβ1 depletion in the mammary gland
Q36950562Controversy surrounding the increased expression of TGF beta 1 in asthma
Q37928833Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix
Q90752446Customizable biomaterials as tools for advanced anti-angiogenic drug discovery
Q26745695Cutting the brakes on hematopoietic regeneration by blocking TGFβ to limit chemotherapy-induced myelosuppression
Q28394607Cyclical strain modulates metalloprotease and matrix gene expression in human tenocytes via activation of TGFβ
Q37550644Defining the role of integrin alphavbeta6 in cancer
Q38580461Dissecting fibrosis: therapeutic insights from the small-molecule toolbox
Q100490624Emerging role of tumor cell plasticity in modifying therapeutic response
Q48336271Endogenous transforming growth factor-beta promotes quiescence of primary microglia in vitro
Q41670915Exploring the Role of RGD-Recognizing Integrins in Cancer
Q34075918Expression of versican V3 by arterial smooth muscle cells alters tumor growth factor β (TGFβ)-, epidermal growth factor (EGF)-, and nuclear factor κB (NFκB)-dependent signaling pathways, creating a microenvironment that resists monocyte adhesion
Q36489766Extracellular angiogenic growth factor interactions: an angiogenesis interactome survey
Q37189687Extracellular matrix-induced gene expression in human breast cancer cells
Q44412857Extracellular matrix‐bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation
Q42831541Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes
Q35063558Gene transcriptional networks integrate microenvironmental signals in human breast cancer
Q43163564Heterogeneous activation of the TGFbeta pathway in glioblastomas identified by gene expression-based classification using TGFbeta-responsive genes
Q36767882Identification and association of TGFβ-1 expression in patients with asthma in a Polish population - Lodz metropolitan area study
Q33492753In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1.
Q37469875Increased activation of latent TGF-β1 by αVβ3 in human Crohn's disease and fibrosis in TNBS colitis can be prevented by cilengitide
Q38622506Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts
Q36512337Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.
Q40545957Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9.
Q36322417Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.
Q39682189Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus
Q24685525Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue
Q92784010Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment
Q35221935Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit
Q37362030Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders
Q38219401Integrins and cadherins as therapeutic targets in fibrosis
Q38631821Integrins and integrin-related proteins in cardiac fibrosis
Q28066805Integrins in the Spotlight of Cancer
Q37590219Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes
Q45893509It has to be the αv: myofibroblast integrins activate latent TGF-β1.
Q33327079Latency associated peptide has in vitro and in vivo immune effects independent of TGF-beta1
Q35861493Latent TGF-beta binding proteins: extracellular matrix association and roles in TGF-beta activation
Q50289818Latent TGF-beta-1 binds integrins
Q34193054Latent Transforming Growth Factor-β-binding Protein 2 Is an Adhesion Protein for Melanoma Cells
Q34619626Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.
Q27002535Matrix control of transforming growth factor-β function
Q38127775Matrix mechanics and regulation of the fibroblast phenotype
Q38166449Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes
Q36909821Methods for identifying novel integrin ligands
Q42563021Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice
Q39364702Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.
Q34078150Mouse models of genetic diseases resulting from mutations in elastic fiber proteins
Q35234874Mutations in a TGF-β ligand, TGFB3, cause syndromic aortic aneurysms and dissections
Q24678290Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix
Q34382264Overexpression of TGF-ß 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-ß.
Q34632691Proteolytic events of wound-healing--coordinated interactions among matrix metalloproteinases (MMPs), integrins, and extracellular matrix molecules
Q24795499RETRACTED: TGFβ1 signaling via αVβ6 integrin
Q28077930Reactive oxygen species and fibrosis: further evidence of a significant liaison
Q26786129Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences
Q33583361Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver
Q36472048Regulation of fibrosis by the immune system
Q39623677Regulation of pulmonary inflammation and fibrosis through expression of integrins alphaVbeta3 and alphaVbeta5 on pulmonary T lymphocytes
Q38851167Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins
Q92384293Regulatory cytokine function in the respiratory tract
Q24635194Review of the activation of TGF-beta in immunity
Q55437873Role of integrin alpha8 in murine model of lung fibrosis.
Q35550776SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity
Q35125022Selective targeting of TGF-β activation to treat fibroinflammatory airway disease
Q90150506Structural insights into conformational switching in latency-associated peptide between transforming growth factor β-1 bound and unbound states
Q35639996TGF-beta signaling in human skeletal and patterning disorders
Q39155183TGF-β Family Signaling in Connective Tissue and Skeletal Diseases
Q33566661TGF-β activation and function in immunity
Q35864472TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.
Q41106710TGF-β1 autocrine signalling and enamel matrix components
Q36694167TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy.
Q60922525TGFβ, smooth muscle cells and coronary artery disease: a review
Q104795035Targeting TGFβ signal transduction for cancer therapy
Q33760068Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis
Q62697773Targeting cytokines to inflammation sites
Q36580090Targeting integrin structure and function in disease
Q37374921Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
Q51763444The dynamics of TGF-β in dental pulp, odontoblasts and dentin.
Q28137622The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
Q24673453The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1
Q40753504The integrin alphaVbeta6 binds and activates latent TGFbeta3.
Q24535009The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3
Q34784557The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium
Q35577299The metastatic tumor antigen 1-transglutaminase-2 pathway is involved in self-limitation of monosodium urate crystal-induced inflammation by upregulating TGF-β1
Q43984586The selective regulation of alpha Vbeta 1 integrin expression is based on the hierarchical formation of alpha V-containing heterodimers
Q35703159The αvβ1 integrin plays a critical in vivo role in tissue fibrosis
Q64265684Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea
Q39010776Transforming Growth Factor β1 Function in Airway Remodeling and Hyperresponsiveness. The Missing Link?
Q35860853Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter.
Q35792147Transforming Growth Factor-β-Dependent and -Independent Pathways of Induction of Tubulointerstitial Fibrosis in β6−/− Mice
Q55423261Transforming Growth Factor-β1/Smad7 in Intestinal Immunity, Inflammation, and Cancer.
Q35172753Transforming growth factor-beta and its role in asthma
Q34438032Transforming growth factor-beta signal transduction in epithelial cells.
Q47102060Two functional domains in C. elegans glypican LON-2 can independently inhibit BMP-like signaling
Q37192207Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation
Q37260433beta8 integrins are required for vascular morphogenesis in mouse embryos
Q36902380α-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFβ activation or collagen production across multiple models of organ fibrosis
Q53620505α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo.
Q35524640αVβ6 integrin promotes corneal wound healing
Q34360208αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice
Q37410984αvβ1 integrin as a novel therapeutic target for tissue fibrosis

Search more.