Extracellular matrix‐bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation

scientific article published on April 22, 2003

Extracellular matrix‐bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1096/FJ.02-0691FJE
P953full work available at URLhttp://www.fasebj.org/cgi/content/abstract/17/11/1520
https://onlinelibrary.wiley.com/doi/full-xml/10.1096/fj.02-0691fje
https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.02-0691fje
P698PubMed publication ID12709411

P2093author name stringNathalie Ortega
Jean Plouët
Helen Hutchings
P2860cites workThe vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.Q40241912
Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.Q40822298
Direct cell adhesion to the angiopoietins mediated by integrinsQ43603092
The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potencyQ44317160
Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect.Q52553091
Extracellular Matrix-derived Peptide Binds to αvβ3Integrin and Inhibits AngiogenesisQ58214922
Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrinsQ61631829
A mechanism for modulation of cellular responses to VEGF: activation of the integrinsQ64380279
Quantification of cells cultured on 96-well platesQ69413909
Autocrine regulation of bovine retinal capillary endothelial cell (BREC) proliferation by BREC-derived basic fibroblast growth factorQ69627589
Xenografts of human solid tumors frequently express cellular-associated isoform of vascular endothelial growth factor (VEGF) 189Q73088081
Vascular endothelial growth factor 189 mRNA isoform expression specifically correlates with tumor angiogenesis, patient survival, and postoperative relapse in non-small-cell lung cancerQ73513573
Cell release of bioactive fibroblast growth factor 2 by exon 6-encoded sequence of vascular endothelial growth factorQ73717921
The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilageQ73880328
Identification of an alpha(3)beta(1) integrin recognition sequence in thrombospondin-1Q78122317
Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.Q22008760
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factorQ24294262
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factorQ24321564
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factorQ24328901
Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1Q24644444
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosisQ28137622
Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]Q28140705
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endotheliumQ28587604
Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceQ28593600
Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleQ29547733
The biology of vascular endothelial growth factorQ29615946
Activation of Rac and Cdc42 by integrins mediates cell spreadingQ29616113
Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vesselsQ29619679
Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycansQ33902687
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cellsQ34047111
Tumstatin, an endothelial cell-specific inhibitor of protein synthesisQ34107979
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoformsQ34787725
Integrin-mediated signals regulated by members of the rho family of GTPasesQ36256316
Simultaneous measurement of cell cycle and apoptotic cell deathQ36897369
alphavbeta3 integrin mediates the cell-adhesive capacity and biological activity of basic fibroblast growth factor (FGF-2) in cultured endothelial cellsQ38615044
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectbiochemistryQ7094
biotechnologyQ7108
geneticsQ7162
endotheliumQ111140
cell adhesionQ187640
extracellular matrixQ193825
P304page(s)1520-1522
P577publication date2003-04-22
P1433published inFASEB JournalQ520194
P1476titleExtracellular matrix-bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation
Extracellular matrix‐bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation
P478volume17

Reverse relations

cites work (P2860)
Q34197864A triad of lys12, lys41, arg78 spatial domain, a novel identified heparin binding site on tat protein, facilitates tat-driven cell adhesion
Q37515471An integrated micro-electro-fluidic and protein arraying system for parallel analysis of cell responses to controlled microenvironments
Q40490472Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway
Q50239732Astrocytes spatially restrict VEGF signaling by polarized secretion and incorporation of VEGF into the actively assembling extracellular matrix
Q36542090Autocrine functions of VEGF in breast tumor cells: adhesion, survival, migration and invasion
Q41912624Beneficial effect of mechanical stimulation on the regenerative potential of muscle-derived stem cells is lost by inhibiting vascular endothelial growth factor.
Q47546891Beyond the Matrix: The Many Non-ECM Ligands for Integrins.
Q38004962Bioactive polymer scaffold for fabrication of vascularized engineering tissue.
Q41601067Chemokine CXCL1 may serve as a potential molecular target for hepatocellular carcinoma
Q35951999Collagen VI ablation retards brain tumor progression due to deficits in assembly of the vascular basal lamina
Q47983641Contribution of vascular endothelial growth factor receptor-2 sialylation to the process of angiogenesis
Q37928833Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix
Q36245636Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan
Q37086277Emerging pulmonary vasculature lacks fate specification
Q34087039Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF.
Q42119488Endothelial cell phenotypic behaviors cluster into dynamic state transition programs modulated by angiogenic and angiostatic cytokines
Q48595604Escherichia coli Nissle 1917 engineered to express Tum-5 can restrain murine melanoma growth
Q55368051Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds.
Q42581018Extracellular matrix stiffness modulates VEGF calcium signaling in endothelial cells: individual cell and population analysis
Q41990778Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton
Q83095845Functional VEGF haplotypes affect the susceptibility to hypertension
Q33809311Functional and structural characteristics of tumor angiogenesis in lung cancers overexpressing different VEGF isoforms assessed by DCE- and SSCE-MRI.
Q55342743Genistein modulates the estrogen receptor and suppresses angiogenesis and inflammation in the murine model of peritoneal endometriosis.
Q34548765Growth factor delivery-based tissue engineering: general approaches and a review of recent developments
Q35976714Human apolipoprotein(a) kringle V inhibits ischemia-induced retinal neovascularization via suppression of fibronectin-mediated angiogenesis
Q37091356In Vitro Endothelialization of Biodegradable Vascular Grafts Via Endothelial Progenitor Cell Seeding and Maturation in a Tubular Perfusion System Bioreactor
Q38878644Inflammatory microenvironment and expression of chemokines in hepatocellular carcinoma
Q37190487Inhibition of tumor angiogenesis by tumstatin: insights into signaling mechanisms and implications in cancer regression
Q24297946Inhibition of β1 integrin and IL-3Rβ common subunit interaction hinders tumour angiogenesis
Q46220745Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis
Q38501776Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation
Q41630032Integrins and p53 pathways in glioblastoma resistance to temozolomide
Q33591910Integrins as "functional hubs" in the regulation of pathological angiogenesis
Q24629255International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy
Q37590219Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes
Q35574990Intracrine vascular endothelial growth factor signaling in survival and chemoresistance of human colorectal cancer cells
Q38634403Localization of VEGF to Vascular ECM Is an Important Aspect of Tumor Angiogenesis
Q24294441MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway
Q82415696Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1
Q30160213Molecular determinants of P2Y2 nucleotide receptor function: implications for proliferative and inflammatory pathways in astrocytes
Q34089123Molecular diversity of VEGF-A as a regulator of its biological activity.
Q36636355Molecular mechanisms of VEGF-A action during tissue repair
Q36552576NG2 Proteoglycan-Dependent Contributions of Pericytes and Macrophages to Brain Tumor Vascularization and Progression
Q35799099NG2 proteoglycan-dependent recruitment of tumor macrophages promotes pericyte-endothelial cell interactions required for brain tumor vascularization
Q30570375Netrin-4 promotes mural cell adhesion and recruitment to endothelial cells.
Q35534079Overexpression of VEGF189 in breast cancer cells induces apoptosis via NRP1 under stress conditions.
Q36357421Overexpression of vascular endothelial growth factor 189 in breast cancer cells leads to delayed tumor uptake with dilated intratumoral vessels
Q35218162P2Y2 nucleotide receptor mediates arteriogenesis in a murine model of hind limb ischemia
Q35087922Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair
Q24678647Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
Q33649673Quantifying the proteolytic release of extracellular matrix-sequestered VEGF with a computational model
Q38156623Role of Angptl4 in vascular permeability and inflammation
Q24295052Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis
Q64252943Shedding New Light on The Role of ανβ3 and α5β1 Integrins in Rheumatoid Arthritis
Q42567361Single and combined effects of alphavbeta3- and alpha5beta1-integrins on capillary tube formation in a human fibrinous matrix
Q33787955Studies on the pathogenesis of avascular retina and neovascularization into the vitreous in peripheral severe retinopathy of prematurity (an american ophthalmological society thesis)
Q37728355Sulfated polymannuroguluronate inhibits Tat-induced SLK cell adhesion via a novel binding site, a KKR spatial triad
Q36918137Synovial fibroblasts spread rheumatoid arthritis to unaffected joints
Q42367752Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition
Q45740855Targeting Heparin to Collagen within Extracellular Matrix Significantly Reduces Thrombogenicity and Improves Endothelialization of Decellularized Tissues
Q41986585The Role of the Endothelium in HPS Pathogenesis and Potential Therapeutic Approaches
Q37565247The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model
Q36390431The role of VEGF receptors in angiogenesis; complex partnerships
Q35706345Three-dimensional cell grafting enhances the angiogenic efficacy of human umbilical vein endothelial cells
Q34385843Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.
Q37953773Tumor angiogenesis: molecular pathways and therapeutic targets
Q35765454Tumor stroma derived biomarkers in cancer
Q47123466Tumstatin regulates the angiogenic and inflammatory potential of airway smooth muscle extracellular matrix
Q35688115VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP.
Q40472491VEGF165 and angiopoietin-1 decreased myocardium infarct size through phosphatidylinositol-3 kinase and Bcl-2 pathways.
Q36949564VEGF: an essential mediator of both angiogenesis and endochondral ossification
Q34488846Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site
Q39153235Vascular endothelial growth factor induces CXCL1 chemokine release via JNK and PI-3K-dependent pathways in human lung carcinoma epithelial cells
Q37745063Vascularization Potential of Electrospun Poly(L-Lactide-co-Caprolactone) Scaffold: The Impact for Tissue Engineering.
Q91899256α4β1 integrin associates with VEGFR2 in CLL cells and contributes to VEGF binding and intracellular signaling
Q26851768αV integrins in angiogenesis and cancer

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