αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice

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αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI43796
P932PMC publication ID2993596
P698PubMed publication ID21099114

P50authorRichard HynesQ2150305
Adam Lacy-HulbertQ41770819
Camille ChowQ57010724
Subhankar MukhopadhyayQ59487610
P2093author name stringLynda M Stuart
Helena Païdassi
Mridu Acharya
Tahseen Jamil
Stephan Kissler
P2860cites workGenome-wide association defines more than 30 distinct susceptibility loci for Crohn's diseaseQ22251069
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionQ24314628
Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1Q24644444
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestineQ24648636
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
IL-17 and Th17 CellsQ27860566
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
Induction of intestinal Th17 cells by segmented filamentous bacteriaQ28131638
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosisQ28137622
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
A genome-wide association study identifies IL23R as an inflammatory bowel disease geneQ28270603
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damageQ28287540
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cellsQ28296956
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Q29547855
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainQ29614225
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitisQ29620481
Increased expression of interleukin 17 in inflammatory bowel diseaseQ29622829
Natural versus adaptive regulatory T cellsQ35092554
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrinsQ36013422
Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null miceQ36117987
Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in miceQ37161107
A protective function for interleukin 17A in T cell-mediated intestinal inflammationQ37260173
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's diseaseQ37284963
The interleukin-23 axis in intestinal inflammationQ37374947
Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiationQ37402405
Interleukin-23/Th17 pathways and inflammatory bowel diseaseQ37404716
Potential role of Th17 cells in the pathogenesis of inflammatory bowel diseaseQ37468451
Late developmental plasticity in the T helper 17 lineageQ39265291
Innate and adaptive interleukin-22 protects mice from inflammatory bowel diseaseQ39902875
Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null miceQ42563021
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibilityQ44808056
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitisQ46625501
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.Q52126962
Effect of cyclic RGD peptide on cell adhesion and tumor metastasisQ67691004
Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiformeQ81615619
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
experimental autoimmune encephalomyelitisQ494066
P304page(s)4445-4452
P577publication date2010-11-22
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleαv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice
P478volume120

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cites work (P2860)
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