The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics

scientific article published on 01 July 2018

The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics is …
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scholarly articleQ13442814

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P356DOI10.1093/BRAIN/AWY131
P932PMC publication ID6022557
P698PubMed publication ID29860380

P50authorKeith A. SharkeyQ38328653
P2093author name stringJonathan B Meddings
V Wee Yong
Carlos R Camara-Lemarroy
Luanne Metz
P2860cites workCoeliac disease presenting with acute disseminated encephalomyelitisQ82611155
Beneficial effect of glatiramer acetate treatment on syndecan-1 expression in dextran sodium sulfate colitisQ83395408
Phenotypic localization of distinct DC subsets in mouse Peyer PatchQ83719308
A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating diseaseQ84371124
Influence of alemtuzumab on the intestinal Paneth cells and microflora in macaquesQ84530839
Silent neurological involvement in biopsy-defined coeliac patientsQ86651937
A CD52 antibody impairs mouse-transplanted intestinal tight junctionsQ86969801
[Cellular composition of Peyer's patches and peripheral lymph nodes in experimental allergic encephalomyelitis during fingolimod therapy]Q95616637
Type I interferon protects against pneumococcal invasive disease by inhibiting bacterial transmigration across the lungQ21131368
Microbial view of central nervous system autoimmunityQ22252213
The potential utility of tight junction regulation in celiac disease: focus on larazotide acetateQ26771888
Teriflunomide: a once-daily oral medication for the treatment of relapsing forms of multiple sclerosisQ26781285
Critical roles of intestinal epithelial vitamin D receptor signaling in controlling gut mucosal inflammationQ26995831
Dendritic cell subsets in the intestinal lamina propria: ontogeny and functionQ26997819
Intestinal barrier in inflammatory bowel diseaseQ27023724
Selective accumulation of pro-inflammatory T cells in the intestine contributes to the resistance to autoimmune demyelinating diseaseQ27323594
Molecular Mimicry Revisited: Gut Bacteria and Multiple SclerosisQ27473292
Inflammatory bowel disease: an increased risk factor for neurologic complicationsQ27690759
Therapeutic potential of fecal microbiota transplantationQ28298108
Can probiotics modulate human disease by impacting intestinal barrier function?Q28817192
Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringensQ28818329
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasisQ29547656
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitisQ29619978
The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.Q30479623
Intravital observation of adhesion of lamina propria lymphocytes to microvessels of small intestine in miceQ31041039
Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration.Q31151767
FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.Q33271908
Norovirus-related chronic diarrhea in a patient treated with alemtuzumab for chronic lymphocytic leukemiaQ33593133
Interaction between the gut microbiome and mucosal immune systemQ33612504
Leaky Gut As a Danger Signal for Autoimmune DiseasesQ33715465
Homeostasis of the gut barrier and potential biomarkersQ33715804
Structure and function of tight junctions. Role in intestinal barrier.Q33781217
Prevalence of celiac disease in multiple sclerosisQ33840141
High frequency of intestinal TH17 cells correlates with microbiota alterations and disease activity in multiple sclerosisQ33898849
Enteropathogenic Escherichia coli inhibits type I interferon- and RNase L-mediated host defense to disrupt intestinal epithelial cell barrier functionQ33899677
Neurological disorders and inflammatory bowel diseasesQ33958822
The blood-brain barrier in multiple sclerosis: microRNAs as key regulators.Q38329179
Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host diseaseQ38460376
Innate lymphoid cells in intestinal immunity and inflammationQ38605374
The IBD interactome: an integrated view of aetiology, pathogenesis and therapy.Q38613269
Cell death at the intestinal epithelial front line.Q38616012
Anti-Adhesion Therapies in Inflammatory Bowel Disease-Molecular and Clinical AspectsQ38643163
Multiple sclerosis and infectionsQ38649264
Neurological disorders and celiac diseaseQ38653470
The role of diet in multiple sclerosis: A review.Q38740469
Type 1 Interferon in the Human Intestine-A Co-ordinator of the Immune Response to the Microbiota.Q38744710
CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice.Q38764574
Developmental expression of STATs, nuclear factor-κB and inflammatory genes in the jejunum of piglets during weaningQ38772188
Influence of the Gut Microbiome on Autoimmunity in the Central Nervous SystemQ38772593
Using peptides to increase transport across the intestinal barrierQ38828115
Dietary Interventions and Multiple SclerosisQ38895161
Celiac Disease: Role of the Epithelial BarrierQ38919389
The intestinal epithelial barrier: a therapeutic target?Q39009998
Multiple sclerosis and inflammatory bowel diseases: a systematic review and meta-analysisQ39017663
Barrier function in the peripheral and central nervous system-a review.Q39037187
Interferon-γ-induced intestinal epithelial barrier dysfunction by NF-κB/HIF-1α pathwayQ39062844
The mucosal barrier at a glance.Q39071909
Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseasesQ39103865
Improvement of a 'Leaky' Intestinal BarrierQ39113717
Contributions of intestinal epithelial barriers to health and diseaseQ39200576
The role of the gut microbiota in sepsisQ39238517
Vitamin D signaling in intestinal innate immunity and homeostasisQ39244762
Type I Interferons Control Proliferation and Function of the Intestinal EpitheliumQ39253946
Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C.Q39268623
Mend Your Fences: The Epithelial Barrier and its Relationship With Mucosal Immunity in Inflammatory Bowel DiseaseQ39339639
Brain Autoimmunity and Intestinal Microbiota: 100 Trillion Game ChangersQ39364276
Intestinal barrier integrity and inflammatory bowel disease: Stem cell-based approaches to regenerate the barrier.Q39388017
Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and nichesQ39394470
Small-bowel abnormalities in multiple sclerosisQ39413550
Layered defense: how mucus and tight junctions seal the intestinal barrierQ39434367
The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties.Q39613921
Gut microbiota in early pediatric multiple sclerosis: a case-control studyQ39768825
Reduced Mass and Diversity of the Colonic Microbiome in Patients with Multiple Sclerosis and Their Improvement with Ketogenic DietQ40137334
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function.Q55052541
Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune responseQ59302315
Multiple sclerosis and celiac disease: is there an increased risk?Q60050559
Leukocyte traffic control: a novel therapeutic strategy for inflammatory bowel diseaseQ62476200
Multiple sclerosis and malabsorptionQ67070212
Endotoxin stimulates lymphocyte-endothelial interactions in rat intestinal Peyer's patches and villus mucosaQ71435832
Involvement of alpha 1 and alpha 4 integrins in gut mucosal injury of graft-versus-host diseaseQ71577663
Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivoQ71616345
Focal white-matter lesions in brain of patients with inflammatory bowel diseaseQ72135622
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L-positive T cells in Peyer's patches by FTY720-induced lymphocyte homingQ77807444
The therapeutic effect of glatiramer acetate in a murine model of inflammatory bowel disease is mediated by anti-inflammatory T-cellsQ80844197
Cerebral White Matter Lesions in Patients with Crohn's DiseaseQ82526705
The lactic acid bacterium Pediococcus acidilactici suppresses autoimmune encephalomyelitis by inducing IL-10-producing regulatory T cellsQ34081672
Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cellsQ34128679
Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 studyQ34168414
Control of TH17 cells occurs in the small intestine.Q34201256
Inflammatory bowel disease: an impaired barrier diseaseQ34312402
Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in miceQ34360200
αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in miceQ34360208
Minocycline attenuates T cell and microglia activity to impair cytokine production in T cell-microglia interactionQ34409724
Host microbiota constantly control maturation and function of microglia in the CNS.Q34478756
The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept studyQ34581861
Reciprocal interaction between intestinal microbiota and mucosal lymphocyte in cynomolgus monkeys after alemtuzumab treatmentQ34596752
A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challengeQ34640687
Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled studyQ34645550
Human Intestinal Barrier Function in Health and DiseaseQ34679342
Epithelial crosstalk at the microbiota-mucosal interface.Q34714672
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillinQ34722535
Multiple sclerosis patients have peripheral blood CD45RO+ B cells and increased intestinal permeabilityQ34737619
Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the diseaseQ35022730
The light and dark sides of intestinal intraepithelial lymphocytesQ35119562
Lymphocyte depletion after alemtuzumab induction disrupts intestinal fungal microbiota in cynomolgus monkeysQ35227850
The gut microbiota influences blood-brain barrier permeability in miceQ35413892
Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosaQ35498107
Gut microbiota in multiple sclerosis: possible influence of immunomodulatorsQ35578319
Peyer's patch innate lymphoid cells regulate commensal bacteria expansionQ35582872
Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial.Q35655989
Topographic distribution of homing receptors on B and T cells in human gut-associated lymphoid tissue: relation of L-selectin and integrin alpha 4 beta 7 to naive and memory phenotypesQ35765315
Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV ClustersQ35773313
Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn's disease: Results from a randomised double-blind placebo-controlled studyQ35780832
Idiopathic inflammatory demyelinating disease of the central nervous system in patients with inflammatory bowel disease: retrospective analysis of 9095 patientsQ35811221
Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.Q35816184
Same Exposure but Two Radically Different Responses to Antibiotics: Resilience of the Salivary Microbiome versus Long-Term Microbial Shifts in FecesQ35837807
Apoptotic epithelial cells control the abundance of Treg cells at barrier surfacesQ35917215
The promise of minocycline in neurology.Q35958974
Gut microbiota composition and relapse risk in pediatric MS: A pilot studyQ35965204
Communicating systems in the body: how microbiota and microglia cooperate.Q36071876
Association of Bactericidal Dysfunction of Paneth Cells in Streptozocin-Induced Diabetic Mice with Insulin DeficiencyQ36116340
Role of intestinal microbiota and metabolites on gut homeostasis and human diseasesQ36243299
Adhesion molecules in inflammatory bowel disease: therapeutic implications for gut inflammation.Q36259898
The dual role of short fatty acid chains in the pathogenesis of autoimmune disease modelsQ36289990
Dimethyl fumarate reduces the risk of mycotoxins via improving intestinal barrier and microbiotaQ36390677
Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox StatusQ36448467
A case of multiple sclerosis and celiac disease.Q36567317
A Urinary Metabolic Signature for Multiple Sclerosis and Neuromyelitis OpticaQ36635131
Disrupted balance of T cells under natalizumab treatment in multiple sclerosis.Q36669122
Effect of alemtuzumab on intestinal intraepithelial lymphocytes and intestinal barrier function in cynomolgus modelQ36807186
TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway.Q36885702
Gut environment-induced intraepithelial autoreactive CD4(+) T cells suppress central nervous system autoimmunity via LAG-3.Q36925537
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptorQ36984429
Mechanisms of Intestinal Barrier Dysfunction in SepsisQ37011812
Role of toll-like receptors in multiple sclerosisQ37021687
Multiple sclerosis patients have a distinct gut microbiota compared to healthy controlsQ37040077
Alterations of the human gut microbiome in multiple sclerosis.Q37060934
Dimethyl Fumarate Reduces Inflammatory Responses in Experimental ColitisQ37098420
Physiology of Intestinal Absorption and SecretionQ37115961
Intestinal epithelial vitamin D receptor signaling inhibits experimental colitisQ37123854
Leukocyte traffic blockade as a therapeutic strategy in inflammatory bowel diseaseQ37188711
Intestinal barrier analysis by assessment of mucins, tight junctions, and α-defensins in healthy C57BL/6J and BALB/cJ miceQ37194625
Induction of gut regulatory CD39+ T cells by teriflunomide protects against EAE.Q37337770
The response of intestinal stem cells and epithelium after alemtuzumab administrationQ37728218
Exploring the immunomodulatory potential of microbial-associated molecular patterns derived from the enteric bacterial microbiota.Q38121384
Lecithin as a therapeutic agent in ulcerative colitis.Q38163748
Neurologic manifestations of inflammatory bowel diseasesQ38173511
Inflammatory bowel disease and demyelination: more than just a coincidence?Q38184633
Alemtuzumab: a new therapy for active relapsing-remitting multiple sclerosisQ38262622
Role of the blood-brain barrier in multiple sclerosisQ38272288
Intestinal barrier homeostasis in inflammatory bowel disease.Q38293757
Anti-TCR antibody treatment activates a novel population of nonintestinal CD8 alpha alpha+ TCR alpha beta+ regulatory T cells and prevents experimental autoimmune encephalomyelitisQ40137961
Isolation and Flow Cytometry Analysis of Innate Lymphoid Cells from the Intestinal Lamina PropriaQ40381607
1,25-Dihydroxyvitamin D Protects Intestinal Epithelial Barrier by Regulating the Myosin Light Chain Kinase Signaling PathwayQ40627574
Pancolitis a novel early complication of Alemtuzumab for MS treatmentQ40654680
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte hominQ41042455
Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses.Q41071305
Metabolomic profiling of CSF in multiple sclerosis and neuromyelitis optica spectrum disorder by nuclear magnetic resonanceQ41137046
Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier DysfunctionQ41673047
A sphingosine-1 phosphate agonist (FTY720) limits trauma/hemorrhagic shock-induced multiple organ dysfunction syndromeQ41836874
Sphingosine-1-Phosphate Regulates the Expression of Adherens Junction Protein E-Cadherin and Enhances Intestinal Epithelial Cell Barrier FunctionQ41854266
Celiac disease with cerebral and peripheral nerve involvement mimicking multiple sclerosis.Q42056074
Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E(1) and E(2) production by intestinal myofibroblastsQ42091545
Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models.Q42221329
Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in miceQ42263596
The chicken or the egg dilemma: intestinal dysbiosis in multiple sclerosisQ42361707
CC chemokine receptor 7-dependent and -independent pathways for lymphocyte homing: modulation by FTY720.Q42944577
Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers.Q43067512
Effect of anti-mouse CD52 monoclonal antibody on mouse intestinal intraepithelial lymphocytesQ43240144
Acute CNS white matter lesions in patients with inflammatory bowel diseaseQ44070852
Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodentsQ44165493
Larazotide acetate promotes tight junction assembly in epithelial cellsQ44979465
Interferon-beta stabilizes barrier characteristics of brain endothelial cells in vitroQ45006682
Antimicrobial susceptibility of bifidobacteriaQ45170021
Therapeutic effect of the immunomodulator glatiramer acetate on trinitrobenzene sulfonic acid-induced experimental colitisQ45242443
Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat.Q45740885
Low sensitivity to glucocorticoid inhibition of in vitro Th17-related cytokine production in multiple sclerosis patients is related to elevated plasma lipopolysaccharide levelsQ45742339
Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study.Q45983167
Minocycline attenuates experimental colitis in mice by blocking expression of inducible nitric oxide synthase and matrix metalloproteinasesQ46088974
The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression: Towards Characterization of the "MS Microbiome".Q46181413
Calcium-mediated oxidative stress: a common mechanism in tight junction disruption by different types of cellular stressQ46436568
Lipopolysaccharide Binding Protein and Oxidative Stress in a Multiple Sclerosis ModelQ46480272
Effect of FTY720 in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.Q46874633
Intestinal Permeability in Relapsing-Remitting Multiple SclerosisQ47577398
Blockade of both L-selectin and alpha4 integrins abrogates naive CD4 cell trafficking and responses in gut-associated lymphoid organsQ47697901
Clinical and metabolic response to probiotic supplementation in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled trial.Q47928580
The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin, and Lipids in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled TrialQ47968211
Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot studyQ48006929
Short-chain fatty acids augment rat duodenal mucosal barrier function.Q48240935
Phosphoinositide 3-kinase γ affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cellsQ48654975
A commensal bacterial product elicits and modulates migratory capacity of CD39(+) CD4 T regulatory subsets in the suppression of neuroinflammationQ48669047
Brain involvement in patients with inflammatory bowel disease: a voxel-based morphometry and diffusion tensor imaging studyQ48672090
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.Q48819558
High resolution proton MR spectroscopy of cerebrospinal fluid in MS patients. Comparison with biochemical changes in demyelinating plaquesQ48844459
Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal BarrierQ49990746
Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury miceQ50203353
The association of minocycline and the probiotic Escherichia coli Nissle 1917 results in an additive beneficial effect in a DSS model of reactivated colitis in mice.Q50525979
Trial of Minocycline in a Clinically Isolated Syndrome of Multiple Sclerosis.Q50610530
Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease.Q52759565
Vitamin D regulates the tight-junction protein expression in active ulcerative colitis.Q53097289
Transverse Myelitis as Manifestation of Celiac Disease in a Toddler.Q53530921
SEW2871 protects from experimental colitis through reduced epithelial cell apoptosis and improved barrier function in interleukin-10 gene-deficient mice.Q53644116
Impact of antimouse CD52 monoclonal antibody on graft's γδ intraepithelial lymphocytes after orthotopic small bowel transplantation in mice.Q54267992
Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression.Q54412643
Severe diarrhoea during Campath-1H treatment for refractory cutaneous T-cell lymphoma.Q54461003
P433issue7
P304page(s)1900-1916
P577publication date2018-07-01
P1433published inBrainQ897386
P1476titleThe intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics
P478volume141