Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

scientific article published on 09 May 2016

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1006359738
P356DOI10.1038/NM.4106
P932PMC publication ID4899206
P698PubMed publication ID27158906

P50authorMarco PrinzQ30055422
Steffen JungQ39989609
Lukas BunseQ55458974
Nathalie PochetQ55465156
Alexandre PratQ56394627
Niroshana AnandasabapathyQ56881400
Clary B ClishQ56988961
Lior MayoQ58657603
Jack P. AntelQ76365827
Guillermo IzquierdoQ87946650
Francisco J. QuintanaQ88364866
Chun-Cheih ChaoQ96074929
P2093author name stringHania Kébir
Jorge I Alvarez
Bonny Patel
Veit Rothhammer
Ivan D Mascanfroni
Raymond Yan
Jessica E Kenison
Maisa C Takenaka
Manon Blain
Nikolaus Obholzer
P2860cites workActivation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cellsQ24293709
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Regulation of type I interferon responsesQ26853177
Aryl hydrocarbon receptor control of adaptive immunityQ26991793
Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tractQ28238242
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptorQ28249782
Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activationQ28250446
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The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasisQ29616351
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cellsQ29618126
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolitesQ29619788
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitisQ29619978
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxinsQ29620097
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamideQ31144277
The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptorQ33587787
Aryl hydrocarbon receptor control of a disease tolerance defence pathwayQ33901562
T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitisQ34107156
The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.Q34131656
Reprogramming human endothelial cells to haematopoietic cells requires vascular inductionQ34157738
Glial cells in the enteric nervous system contain glial fibrillary acidic proteinQ34275211
An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitisQ34375959
The aryl hydrocarbon receptor: multitasking in the immune systemQ34411397
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.Q34632490
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasisQ34646876
Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitisQ35129497
Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progressionQ35564886
Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis.Q35747209
USP18 lack in microglia causes destructive interferonopathy of the mouse brainQ35762623
Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.Q35765467
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptorsQ36058143
Melatonin Contributes to the Seasonality of Multiple Sclerosis RelapsesQ36061629
CNS-specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytesQ36085387
Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitisQ36094091
Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like DementiaQ36146776
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.Q36614277
Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain functionQ36907335
Reproducibility of metabolomic profiles among men and women in 2 large cohort studiesQ37265647
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.Q37403106
Astrocyte barriers to neurotoxic inflammationQ37597818
Diversity of astrocyte functions and phenotypes in neural circuitsQ37601163
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.Q37659617
Heterogeneity of CNS myeloid cells and their roles in neurodegenerationQ37939514
Nuclear factor kappa B (NF-κB) in multiple sclerosis pathologyQ38134459
Mechanisms of white matter damage in multiple sclerosisQ38182524
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cellsQ38336597
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathwaysQ38550041
Astrocyte-encoded positional cues maintain sensorimotor circuit integrity.Q40717814
Regional astrocyte allocation regulates CNS synaptogenesis and repair.Q40757384
Interferon Beta treatment in neuromyelitis optica: increase in relapses and aquaporin 4 antibody titersQ42942128
Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosisQ44897644
Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22.Q45760347
Astronomy: Clue to an ancient cosmic-ray event?Q47193778
New pieces in the puzzle: how does interferon-beta really work in multiple sclerosis?Q47697568
Building up the blood-brain barrierQ48265505
Focal disturbances in the blood-brain barrier are associated with formation of neuroinflammatory lesions.Q48435937
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescenceQ48797548
Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.Q48802284
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.Q48819558
Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression.Q54412643
SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed miceQ56875354
Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous SystemQ56984582
Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in miceQ56984592
TLR signaling tailors innate immune responses in human microglia and astrocytesQ57041985
Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitisQ80819720
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectnervous systemQ9404
astrocyteQ502961
indole-3-carboxaldehydeQ27103575
P304page(s)586-597
P577publication date2016-05-09
P1433published inNature MedicineQ1633234
P1476titleType I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
P478volume22

Reverse relations

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