Characterization of cholesterol homeostasis in telomerase-immortalized Tangier disease fibroblasts reveals marked phenotype variability.

scientific article

Characterization of cholesterol homeostasis in telomerase-immortalized Tangier disease fibroblasts reveals marked phenotype variability. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.500256
P932PMC publication ID3873552
P698PubMed publication ID24196952

P50authorIngemar BjörkhemQ39908514
Michael G. RothQ47662428
P2093author name stringFrank Kannenberg
Manfred Fobker
Kathrin Jäger
Joyce Repa
Michael Walter
Kerstin Gorzelniak
Stephan Rust
P2860cites workMutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiencyQ22010457
NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived OxysterolsQ24300768
Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7beta-hydroxycholesterolQ24301664
Cholesterol quantitation by GLC: artifactual formation of short-chain steryl estersQ70938684
HDL3Stimulates Multiple Signaling Pathways in Human Skin FibroblastsQ71799257
HDL-mediated efflux of intracellular cholesterol is impaired in fibroblasts from Tangier disease patientsQ72235818
Characterization of atherosclerosis in a patient with familial high-density lipoprotein deficiencyQ72526894
Very low high-density lipoproteins without coronary atherosclerosisQ72659041
The high density lipoprotein- and apolipoprotein A-I-induced mobilization of cellular cholesterol is impaired in fibroblasts from Tangier disease subjectsQ72903709
Dietary cholesterol and the activity of stearoyl CoA desaturase in rats: evidence for an indirect regulatory effectQ73337577
Measuring cholesterol in macrophages: comparison of high-performance liquid chromatography and gas-liquid chromatography with enzymatic fluorometryQ73704384
Transient expression of human telomerase extends the life span of normal human fibroblastsQ73984025
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimersQ74253388
Assignment of Tangier disease to chromosome 9q31 by a graphical linkage exclusion strategyQ77220547
Oxysterols and atherosclerosisQ77910747
26-hydroxycholesterol: regulation of hydroxymethylglutaryl-CoA reductase activity in Chinese hamster ovary cell cultureQ93856575
Do oxysterols control cholesterol homeostasis?Q24553299
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbetaQ24553340
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbetaQ24598068
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier diseaseQ28141040
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1Q28141056
THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUMQ29391553
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell lineQ29547239
Accumulation of RhoA, RhoB, RhoG, and Rac1 in fibroblasts from Tangier disease subjects suggests a regulatory role of Rho family proteins in cholesterol effluxQ31855213
Removal of cholesterol from extrahepatic sources by oxidative mechanismsQ33635181
Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2.Q34405624
Cholesterol in health and diseaseQ34809782
Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier DiseaseQ35749982
Cholesterol sensing, trafficking, and esterification.Q36497100
Are side-chain oxidized oxysterols regulators also in vivo?Q37308791
Defective regulation of phosphatidylcholine-specific phospholipases C and D in a kindred with Tangier disease. Evidence for the involvement of phosphatidylcholine breakdown in HDL-mediated cholesterol efflux mechanismsQ37361499
Interrelationships among HDL metabolism, aging, and atherosclerosisQ37576888
Regulation of sterol synthesis in cultured cells by oxygenated derivatives of cholesterolQ39924663
Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha.Q39954571
The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathwayQ40582238
Developmental differences in the immortalization of lung fibroblasts by telomeraseQ40624489
Helical apolipoproteins stabilize ATP-binding cassette transporter A1 by protecting it from thiol protease-mediated degradationQ40738545
Promoter analysis of the mouse sterol regulatory element-binding protein-1c geneQ40864894
The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromesQ40902746
An improved method for quantification of cholesterol and cholesteryl esters in human monocyte-derived macrophages by high performance liquid chromatography with identification of unassigned cholesteryl ester species by means of secondary ion mass spQ40904410
Low density lipoprotein (LDL) cholesterol is converted to 27-hydroxycholesterol in human fibroblasts. Evidence that 27-hydroxycholesterol can be an important intracellular mediator between LDL and the suppression of cholesterol productionQ41333934
Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndromeQ41929357
24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liverQ42289399
Growth and cell cycle abnormalities of fibroblasts from Tangier disease patientsQ42466617
Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasisQ42492641
27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cellsQ43706818
Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductaseQ46891932
Reduction in apolipoprotein-mediated removal of cellular lipids by immortalization of human fibroblasts and its reversion by cAMP: lack of effect with Tangier disease cells.Q53418216
Homozygous Tangier disease and cardiovascular diseaseQ57337269
Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humansQ59307011
P433issue52
P407language of work or nameEnglishQ1860
P921main subjectTangier diseaseQ1442621
P304page(s)36936-36947
P577publication date2013-11-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleCharacterization of cholesterol homeostasis in telomerase-immortalized Tangier disease fibroblasts reveals marked phenotype variability
P478volume288

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cites work (P2860)
Q64935458Biomarkers of response to alpha-lipoic acid ± palmitoiletanolamide treatment in patients with diabetes and symptoms of peripheral neuropathy.
Q33848028High-density lipoprotein metabolism, composition, function, and deficiency
Q35896184LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling
Q26741736Therapeutic Targeting of Telomerase

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