Clostridium difficile 30 years on: what has, or has not, changed and why?

scientific article published on March 2009

Clostridium difficile 30 years on: what has, or has not, changed and why? is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/S0924-8579(09)70008-1
P698PubMed publication ID19303564

P50authorDale N GerdingQ63245110
P2860cites workThe low molecular mass GTP-binding protein Rho is affected by toxin A from Clostridium difficileQ24562382
Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factorQ24634418
Molecular characterization of the Clostridium difficile toxin A geneQ24656092
Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trialQ29394639
Cloning of Clostridium difficile toxin B gene and demonstration of high N-terminal homology between toxin A and B.Q33686152
Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitalsQ33881350
Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A.Q33889330
Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tubeQ33964412
Characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile responsible for a nosocomial outbreak of Clostridium difficile-associated diarrhea.Q33968261
Evaluation of methods for detection of toxins in specimens of feces submitted for diagnosis of Clostridium difficile-associated diarrheaQ33973121
Clostridium difficile and the aetiology of pseudomembranous colitisQ34058811
Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitroQ34214675
Acquisition of Clostridium difficile by hospitalized patients: evidence for colonized new admissions as a source of infectionQ34236809
Prospective randomised trial of metronidazole versus vancomycin for Clostridium-difficile-associated diarrhoea and colitisQ34247700
Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitisQ34281870
Glucosylation of Rho proteins by Clostridium difficile toxin B.Q34312765
A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortalityQ34472139
An epidemic, toxin gene-variant strain of Clostridium difficileQ34472146
A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severityQ34643123
Antibiotic-Associated Pseudomembranous Colitis Due to Toxin-Producing ClostridiaQ34708067
Proton pump inhibitor use and risk of community-acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapyQ35039058
Laboratory diagnosis of Clostridium difficile-associated diarrhoea: a plea for cultureQ36021240
Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic reviewQ36199514
Biological activities of toxins A and B of Clostridium difficileQ36438279
Transcription analysis of the genes tcdA-E of the pathogenicity locus of Clostridium difficileQ38347728
Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease.Q38470026
Antibiotic-induced colitis implication of a toxin neutralised by Clostridium sordellii antitoxinQ39463318
Pseudomembranous colitis: Presence of clostridial toxinQ39472640
Comparison of real-time PCR for detection of the tcdC gene with four toxin immunoassays and culture in diagnosis of Clostridium difficile infectionQ39760796
A case-control study of community-associated Clostridium difficile infectionQ39844072
Development of a rapid and efficient restriction endonuclease analysis typing system for Clostridium difficile and correlation with other typing systemsQ40188190
Decrease in nosocomial Clostridium difficile-associated diarrhea by restricting clindamycin use.Q40699567
Epidemiology of community-acquired Clostridium difficile-associated diarrheaQ40799083
Clindamycin-induced enterocolitis in hamsters as a model of pseudomembranous colitis in patientsQ40910705
Nosocomial acquisition of Clostridium difficile infectionQ41877583
Effective detection of toxigenic Clostridium difficile by a two-step algorithm including tests for antigen and cytotoxinQ41890836
Transcriptional analysis of the toxigenic element of Clostridium difficileQ42652101
Pseudo-membranous colitisQ42929200
Human antibody response to surface layer proteins in Clostridium difficile infectionQ43553287
Human colonic aspirates containing immunoglobulin A antibody to Clostridium difficile toxin A inhibit toxin A-receptor bindingQ43808227
Treatment of antibiotic-associated Clostridium difficile colitis with oral vancomycin: comparison of two dosage regimensQ44770189
Treatment of Clostridium difficile colitis and diarrhea with vancomycinQ45093783
Effect of yogurt on clindamycin-induced Clostridium difficile colitis in hamstersQ45621538
Prospective, controlled study of vinyl glove use to interrupt Clostridium difficile nosocomial transmission.Q45980203
Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrheaQ46376143
Undescribed toxin in pseudomembranous colitisQ50191981
Successful control of Clostridium difficile infection in an elderly care unit through use of a restrictive antibiotic policy.Q54150684
INTESTINAL FLORA IN NEW-BORN INFANTSQ56286565
Association of Interleukin-8 Polymorphism and Immunoglobulin G Anti–Toxin A in Patients With Clostridium difficile–Associated DiarrheaQ61833618
Detection of toxigenic Clostridium difficile in stool specimens by the polymerase chain reactionQ64135847
Treatment of asymptomatic Clostridium difficile carriers (fecal excretors) with vancomycin or metronidazole. A randomized, placebo-controlled trialQ67492785
Systemic and mucosal antibody responses to toxin A in patients infected with Clostridium difficileQ67579613
Reduction in the incidence of Clostridium difficile-associated diarrhea in an acute care hospital and a skilled nursing facility following replacement of electronic thermometers with single-use disposablesQ68065821
Nosocomial Clostridium difficile colonisation and diseaseQ68094486
Clindamycin-associated colitis. A prospective studyQ68788475
Treatment of relapsing Clostridium difficile diarrhoea by administration of a non-toxigenic strainQ68988457
Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patientsQ69370183
Recurrences of Clostridium difficile diarrhea not caused by the original infecting organismQ69943295
Lincomycin as a cause of pseudomembranous colitisQ70004584
Epidemiology of experimental enterocecitis due to Clostridium difficileQ71403009
Antagonism of toxigenic Clostridium difficile by nontoxigenic C. difficileQ71710550
Serum antibody response to toxins A and B of Clostridium difficileQ71831887
Wide diversity of Clostridium difficile types at a tertiary referral hospitalQ72166954
Environmental control to reduce transmission of Clostridium difficileQ73118850
The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardiiQ73118857
Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoeaQ73523895
Primary symptomless colonisation by Clostridium difficile and decreased risk of subsequent diarrhoeaQ74309235
The epidemiology and typing of Clostridium difficileQ74661397
Clostridium difficile toxin expression is inhibited by the novel regulator TcdCQ80416957
Detection of toxigenic Clostridium difficile in stool samples by real-time polymerase chain reaction for the diagnosis of C. difficile-associated diarrheaQ81400778
Protection of hamsters against Clostridium difficile ileocaecitis by prior colonisation with non-pathogenic strainsQ93578151
P921main subjectClostridium difficileQ310543
P304page(s)S2-8
P577publication date2009-03-01
P1433published inInternational Journal of Antimicrobial AgentsQ15724616
P1476titleClostridium difficile 30 years on: what has, or has not, changed and why?
P478volume33 Suppl 1

Reverse relations

cites work (P2860)
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