Evaluation of the antitumor activity of dacomitinib in models of human bladder cancer

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Evaluation of the antitumor activity of dacomitinib in models of human bladder cancer is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1068965627
P356DOI10.2119/MOLMED.2013.00108
P932PMC publication ID3883970
P698PubMed publication ID24166682
P5875ResearchGate publication ID258117022

P2093author name stringMaha Hussain
Lakshmi P Kunju
Dafydd Thomas
Mark L Day
Petros D Grivas
Kathleen C Day
Monica Liebert
Alyssa Paul
Andreas Karatsinides
Iya Owainati
Nazia Shakir
P2860cites workLong-term survival results of a randomized trial comparing gemcitabine/cisplatin and methotrexate/vinblastine/doxorubicin/cisplatin in patients with locally advanced and metastatic bladder cancerQ56749926
Significance of urinary epidermal growth factor and its receptor expression in human bladder cancerQ73311092
Heparin-binding epidermal growth factor-like growth factor isoforms and epidermal growth factor receptor/ErbB1 expression in bladder cancer and their relation to clinical outcomeQ80062040
Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: results of a multicenter phase II National Cancer Institute trialQ80406288
Human epidermal growth factor receptor 2 expression status provides independent prognostic information in patients with urothelial carcinoma of the urinary bladderQ82584712
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The deaf and the dumb: the biology of ErbB-2 and ErbB-3Q28185247
Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro systemQ33747967
Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptorsQ33767107
Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationshipsQ34045509
EGFR and cancer prognosisQ34399312
Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced malignant solid tumorsQ34625315
Effects of mTOR inhibitor everolimus (RAD001) on bladder cancer cellsQ34743802
Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapyQ34866510
Urothelial carcinomas: a focus on human epidermal receptors signalingQ35172558
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor familyQ35173073
Dual kinase inhibition of EGFR and HER2 overcomes resistance to cetuximab in a novel in vivo model of acquired cetuximab resistance.Q36185012
The epidermal growth factor receptor familyQ36236606
Clinical Significance of ErbB Receptor Family in Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-AnalysisQ36238822
HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab.Q36693285
Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancerQ37122307
Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer.Q37659109
Prognostic impact of HER2/neu protein in urothelial bladder cancer. Survival analysis of 80 cases and an overview of almost 20 years' research.Q38419743
Dacomitinib (PF-00299804), an irreversible Pan-HER inhibitor, inhibits proliferation of HER2-amplified breast cancer cell lines resistant to trastuzumab and lapatinibQ39320168
Sunitinib enhances antitumor effects against chemotherapy-resistant bladder cancer through suppression of ERK1/2 phosphorylationQ39394737
The irreversible pan-HER inhibitor PF00299804 alone or combined with gemcitabine has an antitumor effect in biliary tract cancer cell linesQ39422598
Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancerQ39434209
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family membersQ40009294
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinibQ40033522
Combined treatment of bladder cancer cell lines with lapatinib and varying chemotherapy regimens--evidence of schedule-dependent synergyQ40167169
Prognostic significance of Her2/neu overexpression in patients with muscle invasive urinary bladder cancer treated with radical cystectomyQ40170042
Inhibition of the epidermal growth factor receptor in bladder cancer cells treated with the DNA-damaging drug etoposide markedly increases apoptosis.Q40210754
Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expressionQ40318384
Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinomaQ40832646
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude miceQ40971116
Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3Q41107277
Differential radiosensitisation by ZD1839 (Iressa), a highly selective epidermal growth factor receptor tyrosine kinase inhibitor in two related bladder cancer cell linesQ41778604
Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cellsQ42816083
Clinical significance of Her2/neu overexpression in urothelial carcinomas.Q43056122
A single-arm, multicenter, open-label phase 2 study of lapatinib as the second-line treatment of patients with locally advanced or metastatic transitional cell carcinoma.Q46033801
Does HER2 immunoreactivity provide prognostic information in locally advanced urothelial carcinoma patients receiving adjuvant M-VEC chemotherapy?Q46947574
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)367-376
P577publication date2013-11-08
P1433published inMolecular MedicineQ6895961
P1476titleEvaluation of the antitumor activity of dacomitinib in models of human bladder cancer
P478volume19

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cites work (P2860)
Q34081624A randomized phase 2 trial of gemcitabine/cisplatin with or without cetuximab in patients with advanced urothelial carcinoma.
Q38383646Animal models for bladder cancer: The model establishment and evaluation (Review).
Q89748843COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin
Q39198033Dacomitinib for the treatment of advanced or metastatic non-small-cell lung cancer.
Q90101340Dacomitinib: First Global Approval
Q90242172HER2-targeted therapies - a role beyond breast cancer
Q50064748Molecular Correlates of In Vitro Responses to Dacomitinib and Afatinib in Bladder Cancer

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