Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility

scientific article

Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/ANNRHEUMDIS-2012-202357
P932PMC publication ID3887514
P698PubMed publication ID23172754
P5875ResearchGate publication ID233746001

P50authorAnnemie J SchuerweghQ19859568
Gabriela RiemekastenQ21260007
Jane WorthingtonQ29998784
Ariane I. HerrickQ40159573
Anna-Maria Hoffmann-VoldQ42170945
Leonid PadyukovQ42291137
Paul G ShielsQ46191715
Patricia E CarreiraQ51556977
Norberto Ortego-CentenoQ54165708
Javier MartinQ55089349
Annika NordinQ56102262
Lina Marcela Diaz-GalloQ57240458
M.Carmen Fonseca-MoraQ57417374
Gerard EspinosaQ60326205
Claudio LunardiQ60327974
Spanish Scleroderma GroupQ82104105
Alexander KreuterQ87856889
Lorenzo BerettaQ88637275
Bobby KoelemanQ89181050
Maureen D MayesQ89556545
Jörg H W DistlerQ90196418
Miguel Angel Gonzalez-GayQ91377370
Alexandre E VoskuylQ92890691
Madelon C VonkQ94684364
Torsten WitteQ95614543
Jasper BroenQ96130274
Francisco Javier Lopez LongoQ96349187
Roger HesselstrandQ97536973
Paolo AiróQ98175440
Nicolas HunzelmannQ107596492
Timothy R D J RadstakeQ114341720
Carmen Pilar SimeónQ114416252
Rafaella ScorzaQ114417512
José Andrés Román-IvorraQ114417519
Shervin AssasiQ114433881
Frank C ArnettQ121308492
P2093author name stringJacob M van Laar
Christopher P Denton
Xiaodong Zhou
Birgit S Gathof
Esther F Vicente
Carlos Tolosa
Sofia Vargas
P2860cites workGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsQ24550675
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locusQ24630434
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21Q24649802
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetesQ24652324
PLINK: a tool set for whole-genome association and population-based linkage analysesQ24677407
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studiesQ29614926
Autoimmune disease classification by inverse association with SNP allelesQ33521311
Systemic sclerosis and lupus: points in an interferon-mediated continuumQ33889629
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunityQ33918375
Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significanceQ34027620
The pathogenesis of systemic sclerosisQ34150716
Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosisQ34400597
WHAP: haplotype-based association analysisQ34583438
Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21Q35019514
Novel identification of the IRF7 region as an anticentromere autoantibody propensity locus in systemic sclerosisQ36014384
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa miceQ37083674
Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodiesQ37212426
Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genesQ37223270
Transcriptional regulation of IL-2 in health and autoimmunityQ37250679
Interleukin 21 as a target of intervention in autoimmune diseaseQ37331107
Loss of parity between IL-2 and IL-21 in the NOD Idd3 locusQ37429069
Genomics and the multifactorial nature of human autoimmune diseaseQ37949708
Unraveling the genetic component of systemic sclerosisQ37973287
Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria CommitteeQ39513167
Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locusQ41823763
Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitisQ41846939
Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease.Q42622419
Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseasesQ43089300
SclerodermaQ54165664
Consolidation of Evidence for Association of the KIAA1109-TENR-IL2-IL21 rs6822844 Variant With Crohn's DiseaseQ57154893
Stem cell mobilization with G-CSF induces type 17 differentiation and promotes sclerodermaQ57252626
A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21Q57306831
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosusQ57329866
Scleroderma (systemic sclerosis): classification, subsets and pathogenesisQ68330753
Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosisQ80182550
Role of the rs6822844 gene polymorphism at the IL2-IL21 region in biopsy-proven giant cell arteritisQ83304179
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)1233-1238
P577publication date2012-11-21
P1433published inAnnals of the Rheumatic DiseasesQ4767876
P1476titleImplication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility
P478volume72

Reverse relations

cites work (P2860)
Q44047556Association of IL-21 polymorphisms (rs907715, rs2221903) with susceptibility to multiple autoimmune diseases: a meta-analysis
Q26741264Current perspectives on the immunopathogenesis of systemic sclerosis
Q35625469Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report
Q87134135Genetic association of IL-21 polymorphisms with dilated cardiomyopathy in a Han Chinese population
Q26796362Genetics of systemic sclerosis: recent advances
Q26799577Genetics, Epigenetics, and Genomics of Systemic Sclerosis
Q47774368IL-17 and related cytokines involved in systemic sclerosis: Perspectives
Q36619876Identification of an Association of TNFAIP3 Polymorphisms With Matrix Metalloproteinase Expression in Fibroblasts in an Integrative Study of Systemic Sclerosis-Associated Genetic and Environmental Factors
Q58411438Interleukin-17 and interleukin-23: importance in the pathogenesis of lung impairment in patients with systemic sclerosis
Q35826376Investigation of IL-21 gene polymorphisms (rs2221903, rs2055979) in cases with multiple sclerosis of Azerbaijan, Northwest Iran
Q35693212Pathogenesis of Systemic Sclerosis
Q38206152Personalized medicine in systemic sclerosis: facts and promises
Q35865779Scaffolds, levers, rods and springs: diverse cellular functions of long coiled-coil proteins
Q41826432Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes
Q34888501Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.

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