Genomics and the multifactorial nature of human autoimmune disease

scientific article published on October 2011

Genomics and the multifactorial nature of human autoimmune disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1056/NEJMRA1100030
P698PubMed publication ID22029983

P50authorPeter K. GregersenQ7175067
Judy H. ChoQ67426077
P2860cites workFinding the missing heritability of complex diseasesQ22122198
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectautoimmune diseaseQ8084905
genomicsQ222046
P304page(s)1612-1623
P577publication date2011-10-01
P1433published inThe New England Journal of MedicineQ582728
P1476titleGenomics and the multifactorial nature of human autoimmune disease
P478volume365

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cites work (P2860)
Q3882035210% liquid human immunoglobulin (KIOVIG(®)) for immunomodulation in autoimmune disorders
Q39804119A Biomarker Panel to Detect Synchronous Neoplasm in Non-neoplastic Surveillance Biopsies from Patients with Ulcerative Colitis
Q57234939A Possible Role of Different PTPN Genes in Immune Regulation
Q47116537A comparison of health-related quality of life (HRQoL) across four systemic autoimmune rheumatic diseases (SARDs).
Q40507937A mechanistic, stochastic model helps understand multiple sclerosis course and pathogenesis
Q36504045A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease
Q38162671A peptide's perspective on antigen presentation to the immune system
Q44506483A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis.
Q37153818A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci
Q49838415Alloantigen expression on malignant cells and healthy host tissue influences graft-versus-tumor reactions after allogeneic hematopoietic stem cell transplantation
Q35428053Analysis of ancestral and functionally relevant CD5 variants in systemic lupus erythematosus patients
Q34283946Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis.
Q37972803Anti-neutrophil cytoplasmic antibody-associated systemic vasculitis: nature or nurture?
Q38228454Antibodies specific for nucleic acids and applications in genomic detection and clinical diagnostics
Q38016455Antinuclear antibodies in rheumatic disease: a proposal for a function-based classification
Q37365282Apoptosis in response to microbial infection induces autoreactive TH17 cells
Q38681632Association between serum/plasma adiponectin levels and immune-mediated diseases: a meta-analysis.
Q55092221Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus.
Q35050510Association of human leukocyte antigen class II with susceptibility to primary biliary cirrhosis: a systematic review and meta-analysis
Q90339229Association of serum/plasma high mobility group box 1 with autoimmune diseases: A systematic review and meta-analysis
Q33953893Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco
Q92239231Autoantibodies in Morphea: An Update
Q64070262Autoimmune Diseases and Psychotic Disorders
Q35577364Autoimmune host-microbiota interactions at barrier sites and beyond
Q35568398Autoimmune risk loci of IL12RB2, IKZF1, XKR6, TMEM39A and CSK in Chinese patients with systemic lupus erythematosus
Q48722493Autoimmunity's next top models
Q37572837Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics.
Q43987804Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder
Q43086838CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation
Q39271487Candidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI.
Q84006306Cell type-specific eQTLs in the human immune system
Q33415933Class II human leucocyte antigen DRB1*11 in hairy cell leukaemia patients with and without haemolytic uraemic syndrome
Q38074354Clinical guidelines and definitions of autoinflammatory diseases: contrasts and comparisons with autoimmunity-a comprehensive review
Q34669910Clinical implications of copy number variations in autoimmune disorders
Q33837769Coherent somatic mutation in autoimmune disease
Q57307059Common genes in autoimmune diseases: a link between immune-mediated diseases
Q36192435Complicating autoimmune diseases in myasthenia gravis: a review
Q41779945Creatine maintains intestinal homeostasis and protects against colitis
Q92409140Crohn's Disease: Potential Drugs for Modulation of Autophagy
Q26782139Diametrical diseases reflect evolutionary-genetic tradeoffs: Evidence from psychiatry, neurology, rheumatology, oncology and immunology
Q35132241Emerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignancies
Q38159892Endocrine autoimmune diseases and female infertility.
Q64070459Evaluating tofacitinib citrate in the treatment of moderate-to-severe active ulcerative colitis: design, development and positioning of therapy
Q33428734Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs
Q34724067Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition
Q30009882Evidence of new risk genetic factor to systemic lupus erythematosus: the UBASH3A gene.
Q91803384FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis
Q38179269Fibromyalgia and chronic widespread pain in autoimmune thyroid disease
Q34274496From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases
Q37416120Fueling autoimmunity: type I interferon in autoimmune diseases.
Q36593533GWAS implicates a role for quantitative immune traits and threshold effects in risk for human autoimmune disorders
Q38193918Gene-environment interaction in autoimmune disease
Q37086396Genetic analysis of interferon induced thyroiditis (IIT): evidence for a key role for MHC and apoptosis related genes and pathways
Q36204561Genetic associations in acquired immune-mediated bone marrow failure syndromes: insights in aplastic anemia and chronic idiopathic neutropenia
Q37026149Genetics of chronic rhinosinusitis: state of the field and directions forward
Q34545752Genetics of scleroderma: implications for personalized medicine?
Q35921093Genetics of serum concentration of IL-6 and TNFα in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis
Q97522960Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis
Q36708347Genomic modulators of the immune response
Q26991570Genomics, personalized medicine, and pediatrics
Q39894355HLA-A*31 as a marker of genetic susceptibility to sepsis
Q38539811Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies
Q41185159High-resolution gene expression profiling using RNA sequencing in patients with inflammatory bowel disease and in mouse models of colitis.
Q22251082Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Q34622288How do autoimmune diseases cluster in families? A systematic review and meta-analysis
Q38554722Human autoimmune diseases: a comprehensive update
Q30852088Identification of possible pathogenic pathways in Behçet's disease using genome-wide association study data from two different populations
Q45377435Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene
Q38133018Immunopathogenic mechanisms of systemic autoimmune disease
Q34147916Implementation and utilization of genetic testing in personalized medicine
Q37460609Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility
Q52714937In-patient outcomes of Hematopoietic Stem Cell Transplantation in Patients with Immune Mediated Inflammatory Diseases: A Nationwide Study.
Q37549953Influence of sex differences on microRNA gene regulation in disease
Q52641247Innate lymphoid cells in autoimmunity and chronic inflammatory diseases.
Q28066488Intestinal Microbiota as an Alternative Therapeutic Target for Epilepsy
Q37260460Intravascular large B-cell lymphoma associated with silicone breast implant, HLA-DRB1*11:01, and HLA-DQB1*03:01 manifesting as macrophage activation syndrome and with severe neurological symptoms: a case report.
Q57655181Investigation of selected cytokine genes suggests thatIL2RAand theTNF/LTAlocus are risk factors for severe alopecia areata
Q36404704JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
Q38761142JAK inhibition in inflammatory bowel disease
Q34321767JAKs and STATs in immunity, immunodeficiency, and cancer
Q36907640KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor
Q37381383LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity
Q36727669Lack of association between the protein tyrosine phosphatase non-receptor type 22 R263Q and R620W functional genetic variants and endogenous non-anterior uveitis
Q33678499Lack of association of C3 gene with uveitis: additional insights into the genetic profile of uveitis regarding complement pathway genes
Q37058776Latest advances in connective tissue disorders
Q41916915Lentiviral Mediating Genetic Engineered Mesenchymal Stem Cells for Releasing IL-27 as a Gene Therapy Approach for Autoimmune Diseases
Q35532322Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients.
Q36905584Mechanistic biomarkers for clinical decision making in rheumatic diseases
Q37282406New insight on the Xq28 association with systemic sclerosis
Q35060133No evidence of association between common autoimmunity STAT4 and IL23R risk polymorphisms and non-anterior uveitis.
Q38263875Noise in multiple sclerosis: unwanted and necessary
Q28730714Novel associations for hypothyroidism include known autoimmune risk loci
Q40253467Novel insights into systemic autoimmune rheumatic diseases using shared molecular signatures and an integrative analysis
Q36221861Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity.
Q36063925Origin of B-Cell Neoplasms in Autoimmune Disease
Q38655324Oxindole-based SYK and JAK3 dual inhibitors for rheumatoid arthritis: designing, synthesis and biological evaluation
Q38077588Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals
Q52311683Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides.
Q30655444Pathological implications of Th1/Th2 cytokine genetic variants in Behçet's disease: Data from a pilot study in a Sicilian population.
Q38917824Periodontal disease and women's health
Q36100091Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases
Q33956662Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis
Q38371604Proteome dynamics in biobanked horse peripheral blood derived lymphocytes (PBL) with induced autoimmune uveitis.
Q34198746Rasmussen encephalitis and comorbid autoimmune diseases: A window into disease mechanism?
Q57928820Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital
Q37998396Revisiting the old link between infection and autoimmune disease with commensals and T helper 17 cells
Q45126922Rheumatic manifestations of euthyroid, anti-thyroid antibody-positive patients
Q38331233Rheumatic symptoms in autoimmune thyroiditis
Q28943379Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08
Q36430775Rituximab does not reset defective early B cell tolerance checkpoints
Q26829755Role of viruses and bacteria-virus interactions in autoimmunity
Q64235416SLE: reconciling heterogeneity
Q37622868Sex-specific control of central nervous system autoimmunity by p38 mitogen-activated protein kinase signaling in myeloid cells
Q28084677Solving the puzzle of autoimmunity: critical questions
Q36890946Specific peripheral B cell tolerance defects in patients with multiple sclerosis
Q30399603Structural Evaluation and Binding Mode Analysis of CCL19 and CCR7 Proteins-Identification of Novel Leads for Rheumatic and Autoimmune Diseases: An Insilico study
Q91711905Systematic Review of Safety and Efficacy of Atacicept in Treating Immune-Mediated Disorders
Q46264402T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock Proteins
Q41161406Th17 in Animal Models of Rheumatoid Arthritis
Q26747427The Autoimmune Ecology
Q57490878The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?
Q56452307The Multiple Autoimmune Syndromes. A Clue for the Autoimmune Tautology
Q36385156The association between genetic polymorphisms of the interleukin-23 receptor gene and susceptibility to uveitis: a meta-analysis
Q37965346The emerging relationship between neuromyelitis optica and systemic rheumatologic autoimmune disease
Q64099722The emerging role of epigenetics in human autoimmune disorders
Q36918205The genetics of scleroderma: looking into the postgenomic era
Q36490256Therapeutic targeting of the inflammome
Q34651167Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene
Q35134186Unifying immunology with informatics and multiscale biology.
Q28388501Unknown quantity: regulating radionuclides in tap water
Q34030650Update on Janus kinase antagonists in inflammatory bowel disease
Q36127459Urine metabolome profiling of immune-mediated inflammatory diseases
Q37961446Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis
Q35012569What is next after the genes for autoimmunity?

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