Ceftobiprole: first cephalosporin with activity against methicillin-resistant Staphylococcus aureus

scientific article published on May 2009

Ceftobiprole: first cephalosporin with activity against methicillin-resistant Staphylococcus aureus is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1592/PHCO.29.5.511
P698PubMed publication ID19397461

P50authorMichael J RybakQ106082725
P2093author name stringCéline Vidaillac
P2860cites workAntipneumococcal activity of ceftobiprole, a novel broad-spectrum cephalosporinQ42112713
In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infectionsQ42444666
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.Q42584480
Time-kill and synergism studies of ceftobiprole against Enterococcus faecalis, including beta-lactamase-producing and vancomycin-resistant isolatesQ42747697
Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureusQ43183402
BAL 9141, a new broad-spectrum pyrrolidinone cephalosporin: activity against clinically significant anaerobes in comparison with 10 other antimicrobialsQ43895628
Bactericidal activity and synergy studies of BAL9141, a novel pyrrolidinone-3-ylidenemethyl cephem, tested against streptococci, enterococci and methicillin-resistant staphylococciQ44655200
In vitro activity of BAL9141 against clinical isolates of gram-negative bacteriaQ44755053
Bactericidal activity of BAL9141, a novel parenteral cephalosporin against contemporary Gram-positive and Gram-negative isolatesQ45068054
Compatibility of ceftobiprole medocaril with selected drugs during simulated Y-site administrationQ46435928
Incidence, antibiotic resistance and clonal relations of MRSA strains isolated from a Romanian university hospitalQ46572231
In vitro activity of ceftobiprole against clinical isolates of Pseudomonas aeruginosa obtained from Canadian intensive care unit (ICU) patients as part of the CAN-ICU StudyQ46667305
Antimicrobial activity of ceftobiprole, a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, tested against contemporary pathogens: results from the SENTRY Antimicrobial Surveillance Program (2005-2006).Q46667419
A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infectionsQ46787486
In vitro activity profile of ceftobiprole, an anti-MRSA cephalosporin, against recent gram-positive and gram-negative isolates of European originQ46792584
Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992-2003.Q46878727
Activity of ceftobiprole compared with those of other agents against Staphylococcus aureus strains with different resistotypes by time-kill analysisQ46904137
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Methicillin resistance in Staphylococcus aureus: mechanisms and modulationQ34124916
In vitro evaluation of BAL9141, a novel parenteral cephalosporin active against oxacillin-resistant staphylococciQ34162130
Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniaeQ34624359
In vitro activities of ceftobiprole, tigecycline, daptomycin, and 19 other antimicrobials against methicillin-resistant Staphylococcus aureus strains from a national survey of Belgian hospitalsQ34973784
PBP 2a mutations producing very-high-level resistance to beta-lactamsQ35547377
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Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strainsQ36744877
Anti-MRSA beta-lactams in development, with a focus on ceftobiprole: the first anti-MRSA beta-lactam to demonstrate clinical efficacyQ36763997
In-vitro profile of a new beta-lactam, ceftobiprole, with activity against methicillin-resistant Staphylococcus aureusQ36815290
Analysis of cephalosporin antibioticsQ36906409
In vivo pharmacodynamics of ceftobiprole against multiple bacterial pathogens in murine thigh and lung infection modelsQ36932924
Pharmacokinetics and pharmacodynamics of ceftobiprole, an anti-MRSA cephalosporin with broad-spectrum activityQ37030780
Efficacy of BAL5788, a prodrug of cephalosporin BAL9141, in a mouse model of acute pneumococcal pneumoniaQ37119259
Pharmacokinetic and pharmacodynamic profile of ceftobiprole.Q37126977
The efficacy and safety of ceftobiprole in the treatment of complicated skin and skin structure infections: evidence from 2 clinical trialsQ37126984
Increasing antibiotic resistance among methicillin-resistant Staphylococcus aureus strainsQ37156698
Use of Monte Carlo simulations to select therapeutic doses and provisional breakpoints of BAL9141.Q37733667
In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureusQ38899451
In vitro activity of ceftobiprole against aerobic and anaerobic strains isolated from diabetic foot infectionsQ39077347
Postantibiotic effect of ceftobiprole against 12 Gram-positive organismsQ39077719
BAL9141, a novel extended-spectrum cephalosporin active against methicillin-resistant Staphylococcus aureus in treatment of experimental endocarditisQ39650937
In vitro activities of BAL9141, a novel broad-spectrum pyrrolidinone cephalosporin, against gram-negative nonfermentersQ39652995
Single-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteersQ40967997
Multiple-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteersQ40968003
Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureusQ41092910
Activities of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated and hospital-associated methicillin-resistant Staphylococcus aureusQ41336401
Activities of ceftobiprole and other beta-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x.Q41473443
Antistaphylococcal activity of ceftobiprole, a new broad-spectrum cephalosporinQ41847350
Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypesQ42107999
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectStaphylococcus aureusQ188121
methicillin-resistant Staphylococcus aureusQ595158
P304page(s)511-525
P577publication date2009-05-01
P1433published inPharmacotherapyQ7180800
P1476titleCeftobiprole: first cephalosporin with activity against methicillin-resistant Staphylococcus aureus
P478volume29