BAL9141, a novel extended-spectrum cephalosporin active against methicillin-resistant Staphylococcus aureus in treatment of experimental endocarditis

scientific article published on January 2002

BAL9141, a novel extended-spectrum cephalosporin active against methicillin-resistant Staphylococcus aureus in treatment of experimental endocarditis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.46.1.171-177.2002
P8608Fatcat IDrelease_xrzonuneyzb7bak3vhjdendcdi
P932PMC publication ID126986
P698PubMed publication ID11751129

P2093author name stringJ M Entenza
M P Glauser
P Moreillon
P Hohl
I Heinze-Krauss
P2860cites workIn vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococciQ24550612
Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistanceQ28361569
Importance of penicillinase production for activity of penicillin alone or in combination with sulbactam in experimental endocarditis due to methicillin-resistant Staphylococcus aureusQ35124432
Simulation of amoxicillin pharmacokinetics in humans for the prevention of streptococcal endocarditis in ratsQ35823261
Natural history of aortic valve endocarditis in ratsQ36328909
Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococciQ36752622
Beta-Lactam-beta-lactamase-inhibitor combinations are active in experimental endocarditis caused by beta-lactamase-producing oxacillin-resistant staphylococciQ36753343
In vitro and in vivo antistaphylococcal activities of L-695,256, a carbapenem with high affinity for the penicillin-binding protein PBP 2a.Q39779171
Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporinsQ40431109
Evaluation of antibiotic diffusion into cardiac vegetations by quantitative autoradiographyQ41265449
Importance of beta-lactamase inactivation in treatment of experimental endocarditis caused by Staphylococcus aureusQ41611983
Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.Q41696128
Ampicillin, sulbactam, and rifampin combination treatment of experimental methicillin-resistant Staphylococcus aureus endocarditis in rabbitsQ42278485
Antibiotic treatment of experimental endocarditis due to methicillin-resistant Staphylococcus epidermidisQ42283256
The impact of penicillinase on cefamandole treatment and prophylaxis of experimental endocarditis due to methicillin-resistant Staphylococcus aureusQ42545796
New Gram-positive agents in nosocomial infection.Q53973330
The development of vancomycin resistance in a patient with methicillin-resistant Staphylococcus aureus infection.Q54105049
Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.Q55067143
Beta-lactam resistance mechanisms of methicillin-resistant Staphylococcus aureusQ68198941
First clinical isolate of vancomycin-intermediate Staphylococcus aureus in a French hospitalQ74716023
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectStaphylococcus aureusQ188121
methicillin-resistant Staphylococcus aureusQ595158
P304page(s)171-177
P577publication date2002-01-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleBAL9141, a novel extended-spectrum cephalosporin active against methicillin-resistant Staphylococcus aureus in treatment of experimental endocarditis
P478volume46

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cites work (P2860)
Q36233502Anti-MRSA agents: under investigation, in the exploratory phase and clinically available
Q36763997Anti-MRSA beta-lactams in development, with a focus on ceftobiprole: the first anti-MRSA beta-lactam to demonstrate clinical efficacy
Q35588850Antibiotic Resistance in the Treatment of Staphylococcus aureus Keratitis: a 20-Year Review
Q36283731Antibiotic resistance in Staphylococcus aureus and its relevance in therapy
Q36968150Antimicrobial therapy of Staphylococcus aureus bloodstream infection
Q41847350Antistaphylococcal activity of ceftobiprole, a new broad-spectrum cephalosporin
Q44655200Bactericidal activity and synergy studies of BAL9141, a novel pyrrolidinone-3-ylidenemethyl cephem, tested against streptococci, enterococci and methicillin-resistant staphylococci
Q34624359Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae
Q36396146Ceftobiprole efficacy in vitro against Panton-Valentine leukocidin production and in vivo against community-associated methicillin-resistant Staphylococcus aureus osteomyelitis in rabbits
Q42027484Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus
Q43993247Ceftobiprole medocaril is an effective treatment against methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis in a rat model
Q34433342Ceftobiprole medocaril: a review of its use in patients with hospital- or community-acquired pneumonia
Q37762092Ceftobiprole: A novel, broad-spectrum cephalosporin with activity against methicillin-resistant Staphylococcus aureus
Q37519733Ceftobiprole: a new broad spectrum cephalosporin
Q37593094Ceftobiprole: a new cephalosporin for the treatment of skin and skin structure infections
Q37461413Ceftobiprole: first cephalosporin with activity against methicillin-resistant Staphylococcus aureus
Q92304823Ceftobripole: Experience in staphylococcal bacteremia
Q36613912Cephalosporins for uncomplicated skin and skin structure infections in emerging community-acquired MRSA.
Q30369604Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
Q37119259Efficacy of BAL5788, a prodrug of cephalosporin BAL9141, in a mouse model of acute pneumococcal pneumonia
Q38797012Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis.
Q38892614Efficacy of Telavancin Alone and in Combination with Ampicillin in a Rat Model of Enterococcus faecalis Endocarditis
Q36018587Efficacy of ceftobiprole Medocaril against Enterococcus faecalis in a murine urinary tract infection model
Q35026567Emerging agents to combat complicated and resistant infections: focus on ceftobiprole
Q40600643Evaluation of ceftobiprole activity against a variety of gram-negative pathogens, including Escherichia coli, Haemophilus influenzae (β-lactamase positive and β-lactamase negative), and Klebsiella pneumoniae, in a rabbit meningitis model
Q41092910Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus
Q59335521Factors Contributing to the Evolution of -Mediated β-lactam Resistance in Staphylococci: Update and New Insights From Whole Genome Sequencing (WGS)
Q35964560Future trends in antimicrobial chemotherapy: expert opinion on the 43rd ICAAC.
Q42110143In Vivo Effects of Cefazolin, Daptomycin, and Nafcillin in Experimental Endocarditis with a Methicillin-Susceptible Staphylococcus aureus Strain Showing an Inoculum Effect against Cefazolin
Q35124610In vitro activities of a novel cephalosporin, CB-181963 (CAB-175), against methicillin-susceptible or -resistant Staphylococcus aureus and glycopeptide-intermediate susceptible staphylococci
Q33559139In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa
Q36932924In vivo pharmacodynamics of ceftobiprole against multiple bacterial pathogens in murine thigh and lung infection models
Q35191417In vivo synergism of ceftobiprole and vancomycin against experimental endocarditis due to vancomycin-intermediate Staphylococcus aureus
Q53905921Infective endocarditis.
Q33935282Intensive therapy with ceftobiprole medocaril of experimental foreign-body infection by methicillin-resistant Staphylococcus aureus
Q41863839Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium
Q37598693LB11058, a new cephalosporin with high penicillin-binding protein 2a affinity and activity in experimental endocarditis due to homogeneously methicillin-resistant Staphylococcus aureus
Q28235095Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odyssey
Q43491015Methicillin/per-6-(4-methoxylbenzyl)-amino-6-deoxy-β-cyclodextrin 1:1 complex and its potentiation in vitro against methicillin-resistant Staphylococcus aureus
Q35005000Microtiter plate-based assay for inhibitors of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus.
Q40968003Multiple-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteers
Q35056042Novel agents for the treatment of resistant Gram-positive infections
Q35073345Novel antibacterial agents for the treatment of serious Gram-positive infections
Q35547377PBP 2a mutations producing very-high-level resistance to beta-lactams
Q37274751Pharmacodynamic profiling of ceftobiprole for treatment of complicated skin and skin structure infections
Q35879080Probability of target attainment for ceftobiprole as derived from a population pharmacokinetic analysis of 150 subjects
Q35715050Quality control guidelines for BAL9141 (Ro 63-9141), an investigational cephalosporin, when reference MIC and standardized disk diffusion susceptibility test methods are used
Q36422630Results of a double-blind, randomized trial of ceftobiprole treatment of complicated skin and skin structure infections caused by gram-positive bacteria.
Q40967997Single-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteers
Q35111600Solving staphylococcal resistance to β-lactams
Q35806369Synergistic activity of ceftobiprole and vancomycin in a rat model of infective endocarditis caused by methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus
Q44958662The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus
Q42747697Time-kill and synergism studies of ceftobiprole against Enterococcus faecalis, including beta-lactamase-producing and vancomycin-resistant isolates
Q37733667Use of Monte Carlo simulations to select therapeutic doses and provisional breakpoints of BAL9141.

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