Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.

scientific article published on 23 September 2016

Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1101/CSHPERSPECT.A027094
P932PMC publication ID5131751
P698PubMed publication ID27663981

P50authorRakesh JainQ7286601
John D MartinQ57032133
Dai FukumuraQ88059338
P2093author name stringDan G Duda
Yves Boucher
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Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.Q39507131
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A seven-gene set associated with chronic hypoxia of prognostic importance in hepatocellular carcinomaQ39686498
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Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapseQ41110114
Acidic pH enhances the invasive behavior of human melanoma cellsQ41225356
Tissue oxygen distribution in head and neck cancer patientsQ41616158
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical modelQ42573981
Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressureQ42655521
Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metageneQ42739835
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.Q43639734
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.Q34429912
Scaling rules for diffusive drug delivery in tumor and normal tissuesQ34549862
The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancyQ34599918
Stromal disrupting effects of nab-paclitaxel in pancreatic cancerQ34654904
Transdifferentiation of glioblastoma cells into vascular endothelial cellsQ34694093
Vascular permeability, vascular hyperpermeability and angiogenesisQ34753662
Aligned collagen is a prognostic signature for survival in human breast carcinomaQ34760807
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophagesQ34995099
Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancerQ35062862
Tumor mechanics and metabolic dysfunctionQ35117423
Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examinationQ35219246
CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in miceQ35528287
Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasisQ35628173
Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion.Q35680814
Mechanical compression drives cancer cells toward invasive phenotypeQ35734996
Heterogeneity of the tumor vasculatureQ35752502
Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxiaQ30399006
Normalization of the vasculature for treatment of cancer and other diseasesQ30471456
Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancerQ30484735
A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patientsQ30493217
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumorsQ30525290
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalizationQ30579125
The cancer glycocalyx mechanically primes integrin-mediated growth and survivalQ30656235
Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene ExpressionQ30703677
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activationQ33569771
Hypermutable DNA chronicles the evolution of human colon cancerQ33606821
The roles of TGFβ in the tumour microenvironmentQ33630845
Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directionsQ33770680
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinomaQ33896442
The role of mechanical forces in tumor growth and therapyQ33942378
Fibroblast heterogeneity in the cancer woundQ33964324
Stromal response to Hedgehog signaling restrains pancreatic cancer progressionQ34002580
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.Q34045380
Glioblastoma stem-like cells give rise to tumour endothelium.Q34151507
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.Q34151513
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factorsQ34152009
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor ProgressionQ34168497
Automated quantification of aligned collagen for human breast carcinoma prognosisQ34210986
Excessive hyaluronan production promotes acquisition of cancer stem cell signatures through the coordinated regulation of Twist and the transforming growth factor β (TGF-β)-Snail signaling axisQ34249060
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapyQ34253198
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survivalQ34269713
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneityQ34287934
Pathology: cancer cells compress intratumour vessels.Q34299753
Acidity generated by the tumor microenvironment drives local invasionQ34320819
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapyQ34354300
Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabineQ34363486
Tumour heterogeneity in the clinicQ34372080
Malignant cells facilitate lung metastasis by bringing their own soilQ34411553
Compressive stress inhibits proliferation in tumor spheroids through a volume limitationQ34424203
P2507corrigendum / erratumCorrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer HeterogeneityQ42360639
P433issue12
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
heterogeneityQ928498
P577publication date2016-12-01
P1433published inCold Spring Harbor Perspectives in MedicineQ21042440
P1476titleReengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity
P478volume6

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Q42360639Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneitymain subjectP921

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