review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Rakesh Jain | Q7286601 |
John D Martin | Q57032133 | ||
Dai Fukumura | Q88059338 | ||
P2093 | author name string | Dan G Duda | |
Yves Boucher | |||
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Angiotensin system inhibitors and survival outcomes in patients with metastatic renal cell carcinoma. | Q36051199 | ||
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Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases | Q36294948 | ||
Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients. | Q36306066 | ||
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy | Q36378276 | ||
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts | Q36379569 | ||
Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity | Q36459354 | ||
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment | Q36477445 | ||
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer | Q36550798 | ||
Balancing forces: architectural control of mechanotransduction | Q36588911 | ||
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis | Q36671716 | ||
Regulation of DNA repair in hypoxic cancer cells | Q36784378 | ||
Detection and characterization of tumor hypoxia using pO2 histography | Q36834948 | ||
Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis | Q36895504 | ||
A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation | Q36904098 | ||
A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response | Q36905046 | ||
Transforming growth factor-beta and the immune response: implications for anticancer therapy | Q36944384 | ||
Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse | Q36986223 | ||
PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity | Q37014054 | ||
Tumor stroma and regulation of cancer development | Q37014752 | ||
The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy. | Q37081132 | ||
Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. | Q37084096 | ||
The Lymphatic System in Disease Processes and Cancer Progression | Q37099065 | ||
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Tumor-extracellular matrix interactions: Identification of tools associated with breast cancer progression | Q26785362 | ||
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Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia | Q28085029 | ||
Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma | Q28181979 | ||
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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance | Q28269714 | ||
Lysyl oxidase mediates hypoxic control of metastasis | Q28271667 | ||
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Signatures of mutational processes in human cancer | Q29547191 | ||
Molecular mechanisms and clinical applications of angiogenesis | Q29547314 | ||
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion | Q29547317 | ||
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy | Q29547379 | ||
Microenvironmental regulation of metastasis | Q29547660 | ||
A perivascular niche for brain tumor stem cells | Q29614276 | ||
Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy | Q29614312 | ||
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans | Q29614348 | ||
Molecular regulation of vessel maturation | Q29614540 | ||
Targeting hypoxia in cancer therapy | Q29615491 | ||
The causes and consequences of genetic heterogeneity in cancer evolution | Q29615848 | ||
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma | Q29616287 | ||
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine | Q29616728 | ||
The extracellular matrix: not just pretty fibrils | Q29617251 | ||
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia | Q29617501 | ||
Influence of tumour micro-environment heterogeneity on therapeutic response | Q29617534 | ||
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate | Q29617612 | ||
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis | Q29617644 | ||
The extracellular matrix: a dynamic niche in cancer progression | Q29617793 | ||
Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy | Q29618033 | ||
Regulation of angiogenesis by hypoxia: role of the HIF system | Q29619187 | ||
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells | Q29619848 | ||
Intra-tumour heterogeneity: a looking glass for cancer? | Q29620149 | ||
Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy | Q30388746 | ||
A tense situation: forcing tumour progression | Q37112264 | ||
Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy | Q37161504 | ||
Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer | Q37195134 | ||
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells | Q37221453 | ||
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels | Q37250548 | ||
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer | Q37295258 | ||
Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events | Q37310720 | ||
Combining two strategies to improve perfusion and drug delivery in solid tumors | Q37319733 | ||
Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome. | Q37331743 | ||
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. | Q37340643 | ||
Can shear-wave elastography predict response to neoadjuvant chemotherapy in women with invasive breast cancer? | Q37352596 | ||
BRCA1 tumours correlate with a HIF-1alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression | Q37400573 | ||
Multiwell stiffness assay for the study of cell responsiveness to cytotoxic drugs | Q37600858 | ||
Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. | Q37666058 | ||
Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway | Q37723067 | ||
Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity | Q37734258 | ||
Pericytes and vessel maturation during tumor angiogenesis and metastasis | Q37764322 | ||
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche | Q37777514 | ||
Glioblastoma, cancer stem cells and hypoxia | Q37807468 | ||
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases | Q37883025 | ||
Interfering with pH regulation in tumours as a therapeutic strategy | Q37933052 | ||
The lymphatic vasculature in disease | Q37953774 | ||
From stem cells to cancer stem cells: HIF takes the stage | Q37980560 | ||
Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. | Q37995276 | ||
Lymphatic vessels in health and disease | Q38064829 | ||
Markers of response for the antiangiogenic agent bevacizumab | Q38080828 | ||
HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression | Q38112399 | ||
Deciphering and reversing tumor immune suppression. | Q38124437 | ||
Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology | Q38128383 | ||
Hypoxia in tumors: pathogenesis-related classification, characterization of hypoxia subtypes, and associated biological and clinical implications | Q38204334 | ||
Tumor-associated macrophages: from mechanisms to therapy | Q38230880 | ||
Pancreatic stellate cells and pancreas cancer: current perspectives and future strategies | Q38236895 | ||
Using tumour phylogenetics to identify the roots of metastasis in humans. | Q38324281 | ||
Tumorigenesis: it takes a village | Q38544200 | ||
Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment | Q38567779 | ||
Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors | Q38628352 | ||
Targeting Transcriptional and Epigenetic Reprogramming in Stromal Cells in Fibrosis and Cancer | Q38708376 | ||
Antiangiogenic therapy in oncology: current status and future directions | Q38725587 | ||
Acidosis differently modulates the inflammatory program in monocytes and macrophages | Q38825054 | ||
Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery | Q38875758 | ||
Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread | Q38920450 | ||
Tumor vessel normalization by chloroquine independent of autophagy. | Q38966643 | ||
LIF mediates proinvasive activation of stromal fibroblasts in cancer | Q38992217 | ||
Bevacizumab-induced normalization of blood vessels in tumors hampers antibody uptake | Q39167500 | ||
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. | Q39507131 | ||
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha | Q39635625 | ||
Determinants of tumor blood flow: a review | Q39636842 | ||
A seven-gene set associated with chronic hypoxia of prognostic importance in hepatocellular carcinoma | Q39686498 | ||
Sonic hedgehog promotes desmoplasia in pancreatic cancer | Q39933626 | ||
Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38. | Q39946856 | ||
The histological structure of some human lung cancers and the possible implications for radiotherapy | Q39979244 | ||
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity | Q40013431 | ||
Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix. | Q40458180 | ||
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. | Q40479307 | ||
Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells | Q40515728 | ||
Extracellular acidification alters lysosomal trafficking in human breast cancer cells | Q40589703 | ||
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism | Q40738901 | ||
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction | Q40964604 | ||
Gene Expression Signatures Predictive of Bevacizumab/Erlotinib Therapeutic Benefit in Advanced Nonsquamous Non-Small Cell Lung Cancer Patients (SAKK 19/05 trial). | Q41001434 | ||
Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse | Q41110114 | ||
Acidic pH enhances the invasive behavior of human melanoma cells | Q41225356 | ||
Tissue oxygen distribution in head and neck cancer patients | Q41616158 | ||
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model | Q42573981 | ||
Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure | Q42655521 | ||
Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene | Q42739835 | ||
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling. | Q43639734 | ||
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. | Q34429912 | ||
Scaling rules for diffusive drug delivery in tumor and normal tissues | Q34549862 | ||
The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy | Q34599918 | ||
Stromal disrupting effects of nab-paclitaxel in pancreatic cancer | Q34654904 | ||
Transdifferentiation of glioblastoma cells into vascular endothelial cells | Q34694093 | ||
Vascular permeability, vascular hyperpermeability and angiogenesis | Q34753662 | ||
Aligned collagen is a prognostic signature for survival in human breast carcinoma | Q34760807 | ||
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages | Q34995099 | ||
Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer | Q35062862 | ||
Tumor mechanics and metabolic dysfunction | Q35117423 | ||
Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examination | Q35219246 | ||
CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice | Q35528287 | ||
Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis | Q35628173 | ||
Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. | Q35680814 | ||
Mechanical compression drives cancer cells toward invasive phenotype | Q35734996 | ||
Heterogeneity of the tumor vasculature | Q35752502 | ||
Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia | Q30399006 | ||
Normalization of the vasculature for treatment of cancer and other diseases | Q30471456 | ||
Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer | Q30484735 | ||
A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients | Q30493217 | ||
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors | Q30525290 | ||
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization | Q30579125 | ||
The cancer glycocalyx mechanically primes integrin-mediated growth and survival | Q30656235 | ||
Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression | Q30703677 | ||
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation | Q33569771 | ||
Hypermutable DNA chronicles the evolution of human colon cancer | Q33606821 | ||
The roles of TGFβ in the tumour microenvironment | Q33630845 | ||
Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions | Q33770680 | ||
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma | Q33896442 | ||
The role of mechanical forces in tumor growth and therapy | Q33942378 | ||
Fibroblast heterogeneity in the cancer wound | Q33964324 | ||
Stromal response to Hedgehog signaling restrains pancreatic cancer progression | Q34002580 | ||
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. | Q34045380 | ||
Glioblastoma stem-like cells give rise to tumour endothelium. | Q34151507 | ||
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. | Q34151513 | ||
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors | Q34152009 | ||
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression | Q34168497 | ||
Automated quantification of aligned collagen for human breast carcinoma prognosis | Q34210986 | ||
Excessive hyaluronan production promotes acquisition of cancer stem cell signatures through the coordinated regulation of Twist and the transforming growth factor β (TGF-β)-Snail signaling axis | Q34249060 | ||
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy | Q34253198 | ||
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival | Q34269713 | ||
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity | Q34287934 | ||
Pathology: cancer cells compress intratumour vessels. | Q34299753 | ||
Acidity generated by the tumor microenvironment drives local invasion | Q34320819 | ||
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy | Q34354300 | ||
Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine | Q34363486 | ||
Tumour heterogeneity in the clinic | Q34372080 | ||
Malignant cells facilitate lung metastasis by bringing their own soil | Q34411553 | ||
Compressive stress inhibits proliferation in tumor spheroids through a volume limitation | Q34424203 | ||
P2507 | corrigendum / erratum | Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity | Q42360639 |
P433 | issue | 12 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | hypoxia | Q105688 |
heterogeneity | Q928498 | ||
P577 | publication date | 2016-12-01 | |
P1433 | published in | Cold Spring Harbor Perspectives in Medicine | Q21042440 |
P1476 | title | Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity | |
P478 | volume | 6 |
Q90503363 | Bioactive lysolipids in cancer and angiogenesis |
Q59812716 | Characterizing Trastuzumab-Induced Alterations in Intratumoral Heterogeneity with Quantitative Imaging and Immunohistochemistry in HER2+ Breast Cancer |
Q64986589 | Co-administration of Shexiang Baoxin Pill and Chemotherapy Drugs Potentiated Cancer Therapy by Vascular-Promoting Strategy. |
Q89051650 | DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts |
Q90446190 | DZNep inhibits Hif-1α and Wnt signalling molecules to attenuate the proliferation and invasion of BGC-823 gastric cancer cells |
Q98177854 | Development of MicroRNAs as Potential Therapeutics against Cancer |
Q88475926 | Differential expression of IL-6/IL-6R and MAO-A regulates invasion/angiogenesis in breast cancer |
Q90418147 | Diffusion-Weighted MRI Is Insensitive to Changes in the Tumor Microenvironment Induced by Antiangiogenic Therapy |
Q97536610 | Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from protein expression profiling and MRI |
Q90591603 | Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma |
Q92456706 | Gluconeogenesis in cancer cells - Repurposing of a starvation-induced metabolic pathway? |
Q57263190 | Integrative landscape of dysregulated signaling pathways of clinically distinct pancreatic cancer subtypes |
Q38663657 | Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing. |
Q65002844 | Low‑intensity pulsed ultrasound promotes apoptosis and inhibits angiogenesis via p38 signaling‑mediated endoplasmic reticulum stress in human endothelial cells. |
Q48269732 | M1-like macrophages change tumor blood vessels and microenvironment in murine melanoma |
Q87965611 | Macromolecule-Network Electrostatics Controlling Delivery of the Biotherapeutic Cell Modulator TIMP-2 |
Q99632062 | Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective |
Q57484416 | Monitoring of tumor vascular normalization: the key points from basic research to clinical application |
Q39092636 | Order Matters: The Order of Somatic Mutations Influences Cancer Evolution |
Q50657508 | Proteasome Inhibitor-Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-κB Inhibition. |
Q52615294 | Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside. |
Q93239999 | Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy |
Q89638587 | TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity |
Q47722580 | Targeting Inflammation to Improve Tumor Drug Delivery |
Q38654867 | The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer. |
Q50077270 | Tissue Force Programs Cell Fate and Tumor Aggression |
Q39403862 | Tumor angiogenesis and vascular normalization: alternative therapeutic targets |
Q39388967 | Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment. |
Q90292779 | Vascularization, Oxygenation, and the Effect of Sunitinib Treatment in Pancreatic Ductal Adenocarcinoma Xenografts |
Q64100298 | mRNA-to-protein translation in hypoxia |
Q42360639 | Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity | main subject | P921 |
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