Protein kinase D mediates synergistic expression of COX-2 induced by TNF-{alpha} and bradykinin in human colonic myofibroblasts

scientific article published on 30 September 2009

Protein kinase D mediates synergistic expression of COX-2 induced by TNF-{alpha} and bradykinin in human colonic myofibroblasts is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPCELL.00184.2009
P932PMC publication ID2793067
P698PubMed publication ID19794144
P5875ResearchGate publication ID26860766

P2093author name stringJames Yoo
Enrique Rozengurt
James Sinnett-Smith
Christine Chung
Lee Slice
P2860cites workProtein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaBQ24300560
CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epitheliaQ24323341
Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathwayQ24337864
The pleckstrin homology domain of protein kinase D interacts preferentially with the eta isoform of protein kinase CQ28139652
Prostaglandins and cancerQ28188827
Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2Q28259460
Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathwayQ28279767
The versatility and universality of calcium signallingQ29547402
Effect of icatibant, a bradykinin B2 receptor antagonist, on the development of experimental ulcerative colitis in miceQ33178167
Tumor necrosis factor signaling.Q34185821
COX-2: a target for colon cancer preventionQ34504020
Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2.Q34778930
Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigmQ35031770
Emerging and diverse roles of protein kinase C in immune cell signallingQ35564874
Kallikrein–kinin system in inflammatory bowel diseases: Intestinal involvement and correlation with the degree of tissue inflammationQ58418530
Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) miceQ73386832
Kininogen deficiency modulates chronic intestinal inflammation in genetically susceptible ratsQ74301047
Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase CmuQ78208164
Subepithelial myofibroblasts are novel nonprofessional APCs in the human colonic mucosaQ79287415
Localization of cyclooxygenase-2 in human sporadic colorectal adenomasQ35745366
Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammationQ35803526
Protein kinase D signalingQ36035199
Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancerQ36165802
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitisQ36404110
Tumour necrosis factor-alpha as a tumour promoterQ36413908
Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseasesQ36502842
Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylationQ36741576
Biologic therapy in the management of extraintestinal manifestations of inflammatory bowel diseaseQ36849136
Pro-inflammatory prostaglandins and progression of colorectal cancerQ36909506
Mitogenic signaling pathways induced by G protein-coupled receptorsQ36929839
Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription.Q36959617
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signalingQ37011824
Epidermal growth factor-dependent cyclooxygenase-2 induction in gliomas requires protein kinase C-deltaQ39890940
DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttlingQ39907501
Insulin potentiates Ca2+ signaling and phosphatidylinositol 4,5-bisphosphate hydrolysis induced by Gq protein-coupled receptor agonists through an mTOR-dependent pathwayQ40155411
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.Q40350197
Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha.Q40448923
Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1.Q40742637
Regulation of COX-2 expression in human intestinal myofibroblasts: mechanisms of IL-1-mediated inductionQ40746686
Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo.Q40798561
Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.Q41078558
Phenotypic characterization of an intestinal subepithelial myofibroblast cell lineQ41112909
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymesQ41173469
Oxidative stress induces protein kinase D activation in intact cells. Involvement of Src and dependence on protein kinase C.Q41728142
Protein kinase D activation by mutations within its pleckstrin homology domain.Q42448861
Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D.Q42460194
Identification of in vivo phosphorylation sites required for protein kinase D activation.Q42462150
Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease.Q42476384
Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosisQ42580022
Bombesin, vasopressin, endothelin, bradykinin, and platelet-derived growth factor rapidly activate protein kinase D through a protein kinase C-dependent signal transduction pathway.Q42795887
Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cellsQ42826316
G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein kinase CepsilonQ42828192
Protein kinase D potentiates DNA synthesis induced by Gq-coupled receptors by increasing the duration of ERK signaling in swiss 3T3 cellsQ42831514
Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain.Q44198663
Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomasQ45050406
Cytoplasmic phospholipase A2 alpha overexpression in stromal cells is correlated with angiogenesis in human colorectal cancerQ45099763
Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascadeQ45309112
Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblastsQ46429130
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cdelta activationQ46510703
Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C.Q46603822
Roles of myofibroblasts in prostaglandin E2-stimulated intestinal epithelial proliferation and angiogenesisQ46902047
Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesisQ46942023
Inflammation in the genesis and perpetuation of cancer: summary and recommendations from a national cancer institute-sponsored meeting.Q53353787
Myofibroblast matrix metalloproteinases activate the neutrophil chemoattractant CXCL7 from intestinal epithelial cells.Q53641500
Immunohistochemical study of myofibroblasts in normal colonic mucosa, hyperplastic polyps, and adenomatous colorectal polyps.Q54542890
Matrix metalloproteinase-3 secretion from human pancreatic periacinar myofibroblasts in response to inflammatory mediators.Q54564729
P433issue6
P921main subjectTNFQ18032037
P304page(s)C1576-87
P577publication date2009-09-30
P1433published inAmerican Journal of Physiology - Cell PhysiologyQ2227080
P1476titleProtein kinase D mediates synergistic expression of COX-2 induced by TNF-{alpha} and bradykinin in human colonic myofibroblasts
P478volume297

Reverse relations

cites work (P2860)
Q90325961Angiogenin regulates PKD activation and COX-2 expression induced by TNF-α and bradykinin in the colonic myofibroblast
Q36837922Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis.
Q38723867Bradykinin stimulates protein kinase D-mediated colonic myofibroblast migration via cyclooxygenase-2 and heat shock protein 27.
Q37613363Isolation of primary myofibroblasts from mouse and human colon tissue
Q34180271Mechanistic insight into the ability of American ginseng to suppress colon cancer associated with colitis
Q54977098Protein kinase Cε regulates nuclear translocation of extracellular signal-regulated kinase, which contributes to bradykinin-induced cyclooxygenase-2 expression.
Q28537962Protein kinase D interacts with neuronal nitric oxide synthase and phosphorylates the activatory residue serine 1412
Q39348454Protein kinase D signaling in cancer: A friend or foe?
Q35239280Protein kinase D signaling: multiple biological functions in health and disease
Q35223677Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-α and bradykinin in human colonic myofibroblasts
Q34279846Role of protein kinase D signaling in pancreatic cancer
Q40001918Serum concentrations of cyclooxygenase-2 in patients with systemic sclerosis: association with lower frequency of pulmonary fibrosis
Q34729143TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR.
Q35970190TNF-α induces upregulation of EGFR expression and signaling in human colonic myofibroblasts
Q34784001TNF-α potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts
Q33565290TNF-α stimulates colonic myofibroblast migration via COX-2 and Hsp27

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