Interactions between MDM2 and TP53 Genetic Alterations, and Their Impact on Response to MDM2 Inhibitors and Other Chemotherapeutic Drugs in Cancer Cells.

scientific article published on December 2009

Interactions between MDM2 and TP53 Genetic Alterations, and Their Impact on Response to MDM2 Inhibitors and Other Chemotherapeutic Drugs in Cancer Cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-09-0890
P932PMC publication ID2794936
P698PubMed publication ID19996219

P50authorMark J RatainQ87725760
Wanqing LiuQ40121377
P2093author name stringLijun He
Jacqueline Ramírez
P2860cites workA single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humansQ40490424
Clinical implications of the p53 geneQ41036383
Mdm2 promotes genetic instability and transformation independent of p53.Q41337111
Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort studyQ46465639
Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemiaQ73359066
Somatic mutations affect key pathways in lung adenocarcinomaQ24648102
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyQ24651380
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistanceQ28366242
Cancer. Addiction to oncogenes--the Achilles heal of cancerQ29614243
The NCI60 human tumour cell line anticancer drug screenQ29614975
A gene expression database for the molecular pharmacology of cancerQ29619242
The MDM2 gene amplification databaseQ34672224
Cell cycle regulatory functions of the human oncoprotein MDM2.Q35621045
Haplotype structure and selection of the MDM2 oncogene in humansQ35721519
MDM2 inhibitors for cancer therapyQ36663493
MDMX: from bench to bedsideQ36717697
A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humansQ36745377
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.Q37250634
Relationship of EGFR mutations, expression, amplification, and polymorphisms to epidermal growth factor receptor inhibitors in the NCI60 cell linesQ40050748
Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugsQ40118494
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectchemotherapyQ974135
P304page(s)7602-7607
P577publication date2009-12-01
P1433published inClinical Cancer ResearchQ332253
P1476titleInteractions between MDM2 and TP53 Genetic Alterations, and Their Impact on Response to MDM2 Inhibitors and Other Chemotherapeutic Drugs in Cancer Cells
P478volume15

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cites work (P2860)
Q34768681A genome-wide integrative study of microRNAs in human liver
Q37019200A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival
Q34406172Allele Loss and Down-Regulation of Heparanase Gene Are Associated with the Progression and Poor Prognosis of Hepatocellular Carcinoma
Q90298995An evaluation in vitro of the efficacy of nutlin-3 and topotecan in combination with 177Lu-DOTATATE for the treatment of neuroblastoma
Q37738067An investigation of the role of gene copy number variations in sorafenib sensitivity in metastatic hepatocellular carcinoma patients
Q39103518Association between hTERT rs2736100 polymorphism and sensitivity to anti-cancer agents
Q33917547Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing
Q90427860MDM4 contributes to the increased risk of glioma susceptibility in Han Chinese population
Q35030217Targeting MDM2-p53 interaction for cancer therapy: are we there yet?
Q55517350The Roles of MDM2 and MDMX in Cancer.
Q37803120Translating p53 into the clinic.
Q35995829Whole genome sequence analysis links chromothripsis to EGFR, MDM2, MDM4, and CDK4 amplification in glioblastoma

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