An evaluation in vitro of the efficacy of nutlin-3 and topotecan in combination with 177Lu-DOTATATE for the treatment of neuroblastoma

scientific article published on 26 June 2018

An evaluation in vitro of the efficacy of nutlin-3 and topotecan in combination with 177Lu-DOTATATE for the treatment of neuroblastoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.25607
P932PMC publication ID6044389
P698PubMed publication ID30018737

P50authorColin RaeQ57628906
P2093author name stringColin Nixon
Andreas Hock
Mathias Tesson
Richa Vasan
Mark Gaze
Robert Mairs
P2860cites workPPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsQ24527393
Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanomaQ39505317
Differentiated expression of somatostatin receptor subtypes in experimental models and clinical neuroblastomaQ39596829
MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.Q39617806
New Strategies in Refractory and Recurrent Neuroblastoma: Translational Opportunities to Impact Patient OutcomeQ39639490
Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavageQ39790130
A dominant role for p53-dependent cellular senescence in radiosensitization of human prostate cancer cells.Q40160733
[131I]meta-iodobenzylguanidine and topotecan combination treatment of tumors expressing the noradrenaline transporterQ40352960
Initial Experience With Gallium-68 DOTA-Octreotate PET/CT and Peptide Receptor Radionuclide Therapy for Pediatric Patients With Refractory Metastatic NeuroblastomaQ40619458
Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell lineQ40825639
Long-Term Retention of 177Lu/177mLu-DOTATATE in Patients Investigated by γ-Spectrometry and γ-Camera ImagingQ40913291
Growth and characterization of LNCaP prostate cancer cell spheroidsQ40920874
Characterization of somatostatin receptors on human neuroblastoma tumors.Q41500083
Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activityQ41561051
Upfront treatment of high-risk neuroblastoma with a combination of 131I-MIBG and topotecanQ41733479
Correlation of Somatostatin Receptor-2 Expression with Gallium-68-DOTA-TATE Uptake in Neuroblastoma Xenograft ModelsQ43376054
Phase II study on the effect of disease sites, age, and prior therapy on response to iodine-131-metaiodobenzylguanidine therapy in refractory neuroblastoma.Q45947406
Mutation of the p53 gene in neuroblastoma and its relationship with N-myc amplification.Q45972216
Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitroQ46252964
Feasibility of dosimetry-based high-dose 131I-meta-iodobenzylguanidine with topotecan as a radiosensitizer in children with metastatic neuroblastomaQ46470457
Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survivalQ46735215
Cytoskeletal interference - A new mode of action for the anticancer drugs camptothecin and topotecanQ47863538
Identification, characterization, and biological activity of somatostatin receptors in human neuroblastoma cell lines.Q52384283
Radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2.Q53634741
A simplified method for production and growth of multicellular tumor spheroidsQ67684815
The relationship between tumour geometry and the response of tumour cells to cytotoxic drugs--an in vitro study using EMT6 multicellular spheroidsQ70110627
Low frequency of the p53 gene mutations in neuroblastomaQ72496549
Quantitative determination of sst2 gene expression in neuroblastoma tumor predicts patient outcomeQ73148522
Quantitation of somatostatin receptor type 2 gene expression in neuroblastoma cell lines and primary tumors using competitive reverse transcription-polymerase chain reactionQ77556300
Chemical Variations on the p53 Reactivation ThemeQ26749008
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerizationQ27670558
MDM2 is an important prognostic and predictive factor for platin-pemetrexed therapy in malignant pleural mesotheliomas and deregulation of P14/ARF (encoded by CDKN2A) seems to contribute to an MDM2-driven inactivation of P53.Q27853125
Correlation of TP53 and MDM2 genotypes and clinical outcome in platinum-treated head and neck cancer patients with more than 10 years' follow-upQ27853350
The inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatmentQ28483781
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomasQ29616243
Restoration of p53 function leads to tumour regression in vivoQ29618727
Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A).Q31777917
Glioma cell sensitivity to topotecan: the role of p53 and topotecan-induced DNA damageQ31885912
177Lu-DOTATATE molecular radiotherapy for childhood neuroblastomaQ33395827
Phase I Trial of the Human Double Minute 2 Inhibitor MK-8242 in Patients With Advanced Solid Tumors.Q33439682
High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed NeuroblastomaQ33743767
Modeling the therapeutic efficacy of p53 restoration in tumorsQ34593294
Novel targeted therapeutics: inhibitors of MDM2, ALK and PARPQ35011473
Wild type p53 reactivation: from lab bench to clinic.Q35146343
Expressions of Somatostatin Receptor Subtypes (SSTR-1, 2, 3, 4 and 5) in Neuroblastic Tumors; Special Reference to Clinicopathological Correlations with International Neuroblastoma Pathology Classification and OutcomesQ35288725
Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiationQ35681140
The p53 tumor suppressor participates in multiple cell cycle checkpointsQ36495323
Interactions between MDM2 and TP53 Genetic Alterations, and Their Impact on Response to MDM2 Inhibitors and Other Chemotherapeutic Drugs in Cancer Cells.Q37480094
Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis.Q37518896
Preclinical Assessment of Strategies for Enhancement of Metaiodobenzylguanidine Therapy of Neuroendocrine TumorsQ37908692
Molecular mechanisms of somatostatin receptor traffickingQ37967158
Optimization of molecular radiotherapy with [131I]-meta Iodobenzylguanidine for high-risk neuroblastomaQ38087832
A systematic review of 131I-meta iodobenzylguanidine molecular radiotherapy for neuroblastomaQ38170852
Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study.Q38354018
Incorporation of iododeoxyuridine in multicellular glioma spheroids: implications for DNA-targeted radiotherapy using Auger electron emittersQ38559192
Peptide receptor radionuclide therapy of neuroendocrine tumoursQ38772485
Preliminary evaluation of prostate-targeted radiotherapy using (131) I-MIP-1095 in combination with radiosensitising chemotherapeutic drugsQ38773634
Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicityQ38845519
The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancerQ38858580
Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastomaQ38890690
Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastomaQ38985584
Immunocytochemical localization of somatostatin receptor sst2A in the rat spinal cord and dorsal root gangliaQ39442481
P4510describes a project that usesImageJQ1659584
P433issue49
P921main subjectneuroblastomaQ938205
lutetium-177Q18882670
P304page(s)29082-29096
P577publication date2018-06-26
P1433published inOncotargetQ1573155
P1476titleAn evaluation in vitro of the efficacy of nutlin-3 and topotecan in combination with 177Lu-DOTATATE for the treatment of neuroblastoma
P478volume9

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