The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer

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The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.4433
P932PMC publication ID4673190
P698PubMed publication ID26125230

P50authorVanessa DeschoolmeesterQ40933684
Jolien Van den BosscheQ40933783
Julie JacobsQ59662550
An WoutersQ38324398
Filip LardonQ38324438
Ken Op de BeeckQ38641314
P2093author name stringChristian Rolfo
Patrick Pauwels
Marc Peeters
Karen Zwaenepoel
Jan Van Meerbeeck
Christophe Deben
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Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.Q41350117
Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancerQ46892013
HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.Q52581241
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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer ModelsQ27683975
Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiformeQ28477660
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosisQ28575693
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsQ29547463
Significance of TP53 mutations as predictive markers of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer.Q30358684
Growing clinical evidence for the interaction of the p53 genotype and response to induction chemotherapy in advanced non-small cell lung cancerQ33331636
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism studyQ33403930
Small-molecule inhibitors of MDM2 as new anticancer therapeuticsQ33515500
Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatmentQ33533630
Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activationQ33808489
MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell linesQ33915624
Cellular Responses to Cisplatin‐Induced DNA DamageQ34089685
Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time technology and classic endpoint assaysQ34456201
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapyQ34478557
The MDM2 gene amplification databaseQ34672224
Awakening guardian angels: drugging the p53 pathwayQ35014385
Drugging the p53 pathway: understanding the route to clinical efficacyQ38191796
Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approachQ38996797
Correlation of TP53 and MDM2 genotypes with response to therapy in sarcomaQ39242233
Mdm2 antagonists induce apoptosis and synergize with cisplatin overcoming chemoresistance in TP53 wild-type ovarian cancer cellsQ39282673
Restoration of p53 pathway by nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cellsQ39840685
PRIMA-1 reactivates mutant p53 by covalent binding to the core domainQ39857551
Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.Q40200606
P433issue26
P407language of work or nameEnglishQ1860
P921main subjectcisplatinQ412415
lung cancerQ47912
apoptotic processQ14599311
P304page(s)22666-22679
P577publication date2015-06-10
P1433published inOncotargetQ1573155
P1476titleThe MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer
P478volume6

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