Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation

scientific article published on 20 October 2015

Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.6194
P932PMC publication ID5355047
P698PubMed publication ID26498357
P5875ResearchGate publication ID283261185

P2093author name stringMin Chen
Ming Zeng
De Chen
Guang-Rong Yan
Song-Hui Xu
Fei-Yan Zou
Jin-Zhou Huang
P2860cites workA human gene, hSGT1, can substitute for GCR2, which encodes a general regulatory factor of glycolytic gene expression in Saccharomyces cerevisiaeQ22008751
Global cancer statisticsQ22241238
Shepherding AKT and androgen receptor by Ack1 tyrosine kinaseQ24308859
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42Q24336649
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapyQ26798420
Development of novel ACK1/TNK2 inhibitors using a fragment-based approachQ28257452
Ack1 Tyrosine Kinase Activation Correlates with Pancreatic Cancer ProgressionQ28259414
Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor WwoxQ28281831
ACK1 tyrosine kinase: targeted inhibition to block cancer cell proliferationQ28289188
Role of mammalian Ecdysoneless in cell cycle regulationQ28588460
Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate dataQ31044850
Regulation of the G2/M transition by p53.Q33943437
Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1Q34116116
Detection of kinase amplifications in gastric cancer archives using fluorescence in situ hybridization.Q34301120
ACK1 tyrosine kinase interacts with histone demethylase KDM3A to regulate the mammary tumor oncogene HOXA1Q34317299
Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesisQ34318903
Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancerQ34786561
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancersQ35542942
Variation in gene expression patterns in human gastric cancersQ35670324
A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targetsQ35878807
clusterProfiler: an R package for comparing biological themes among gene clusters.Q35920061
MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancerQ36544947
Overexpression of Ecdysoneless in Pancreatic Cancer and Its Role in Oncogenesis by Regulating GlycolysisQ36551562
Advanced gastric cancer--slow but steady progressQ37696790
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lungQ38390024
Gastric cancer and gene copy number variation: emerging cancer drivers for targeted therapy.Q38527414
The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancerQ38858580
Activated cdc42-associated kinase is up-regulated in non-small-cell lung cancer and necessary for FGFR-mediated AKT activationQ38878596
ACK1 promotes gastric cancer epithelial-mesenchymal transition and metastasis through AKT-POU2F1-ECD signalling.Q38910111
Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study.Q39298676
Proteomics characterization of gastrokine 1-induced growth inhibition of gastric cancer cellsQ39507524
The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its functionQ40254022
A role for the tyrosine kinase ACK1 in neurotrophin signaling and neuronal extension and branchingQ41271150
Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and SenescenceQ43120565
TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancerQ43413038
Genome-wide expression profile of sporadic gastric cancers with microsatellite instabilityQ57419727
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectprotein ubiquitinationQ3547638
P304page(s)12705-12716
P577publication date2015-10-20
P1433published inOncotargetQ1573155
P1476titleAmplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation
P478volume8

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cites work (P2860)
Q98466214Comprehensive Analysis of the Immune Implication of ACK1 Gene in Non-small Cell Lung Cancer
Q52715849ECD promotes gastric cancer metastasis by blocking E3 ligase ZFP91-mediated hnRNP F ubiquitination and degradation
Q47150016Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry
Q38708087Mammalian ECD Protein Is a Novel Negative Regulator of the PERK Arm of the Unfolded Protein Response
Q88796727Molecular alterations of cancer cell and tumour microenvironment in metastatic gastric cancer
Q49887894Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products.

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